ナチスに抗した勤労青少年 －ウィーンの「シュルルフ」

departmental bulletin pape

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

This article has been corrected. https://doi.org/10.1007/s11604-023-01418-xJapanese Journal of Radiology. 2023, 41, P.808-829journal articl

Correction to: Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

Original article: https://doi.org/10.1007/s11604-023-01407-0Japanese Journal of Radiology. 2023, 41, P.830journal articl

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 1. Pituitary neuroendocrine tumor (PitNET)/pituitary adenoma

This article has been corrected. https://doi.org/10.1007/s11604-023-01414-1Japanese Journal of Radiology. 2023, 41, P.789-806journal articl

Correction to: Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 1. Pituitary neuroendocrine tumor (PitNET)/pituitary adenoma

Original article: https://doi.org/10.1007/s11604-023-01400-7Japanese Journal of Radiology. 2023, 41, P.807journal articl

2011（平成23）年度鳥取大学教員免許状更新講習実施状況

departmental bulletin pape

In vitro characterization of missense mutations associated with quantitative protein Sdeficiency

名古屋大学NAGOYA University博士(医療技術学)Objective: To elucidate the molecular consequences of hereditary protein S (PS) deficiency, we investigated the in vitro synthesis of the PS missense mutants in COS-1 cells and their activated protein C (APC) cofactor activities. Patients: Four patients with quantitative PS deficiency suffering from venous thrombosis were examined. Results: We identified three distinct novel missense mutations, R275C, P375Q and D455Y, and two previously reported missense mutations, C80Y and R314H. The P375Q and D455Y mutations were found in one patient and observed to be in linkage on the same allele. The R314H mutant showed the lowest level of expression (32.7%), and the C80Y, P375Q + D455Y, and R275C mutants exhibited a moderate impairment of expression, that is, 43.8%, 49.5%, and 72.3% of the wild type, respectively. Furthermore, pulse-chase experiments demonstrated that all mutants showed impaired secretion and longer half-lives in the cells than the wild type PS. In the APC cofactor assays, the C80Y mutant showed no cofactor activity, and the R275C mutant showed reduced activity, 62.3% of the wild type PS, whereas the R314H and P375Q + D455Y mutants exhibited normal cofactor activity. Conclusion: These data indicate that the C80Y and R275C mutations affect the secretion and function of the PS molecule, and that the R314H and P375Q + D455Y mutations are responsible for only secretion defects, causing the phenotype of quantitative PS deficiency observed in the patients.名古屋大学博士学位論文 学位の種類:博士（医療技術学）（課程）学位授与年月日:平成19年3月23日In vitro characterization of missense mutations associated with quantitative protein Sdeficiency Schattauer, v.4, iss.9, pp.2003-2009を、博士論文として提出したもの。doctoral thesi

Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset

Japanese Journal of Radiology. 2022, 41, P.393-400journal articl

Observation of the DsJ(2317) and DsJ(2457) in B Decays

journal articl

SOME CONDITIONS FOR UNIVALENCE DEFINED BY RUSCHEWEYH'S DERIVATIVE

application/pdfFor a function ＄ f(z)=z+a_{2}z^{2}+￥cdots＄ analytic in the unit disc we give certain criteria for univalence in terms of ＄(D^{n}f(z))/z＄ , where ＄D^{n}f＄ denotes the Ruscheweyh derivative.departmental bulletin pape