10 research outputs found
A comparative study about proverbs that include physical terms in Japanese and Korean languages
departmental bulletin pape
In vitro characterization of missense mutations associated with quantitative protein Sdeficiency
名古屋大学NAGOYA University博士(医療技術学)Objective: To elucidate the molecular consequences of hereditary protein S (PS) deficiency, we investigated the in vitro synthesis of the PS missense mutants in COS-1 cells and their activated protein C (APC) cofactor activities. Patients: Four patients with quantitative PS deficiency suffering from venous thrombosis were examined. Results: We identified three distinct novel missense mutations, R275C, P375Q and D455Y, and two previously reported missense mutations, C80Y and R314H. The P375Q and D455Y mutations were found in one patient and observed to be in linkage on the same allele. The R314H mutant showed the lowest level of expression (32.7%), and the C80Y, P375Q + D455Y, and R275C mutants exhibited a moderate impairment of expression, that is, 43.8%, 49.5%, and 72.3% of the wild type, respectively. Furthermore, pulse-chase experiments demonstrated that all mutants showed impaired secretion and longer half-lives in the cells than the wild type PS. In the APC cofactor assays, the C80Y mutant showed no cofactor activity, and the R275C mutant showed reduced activity, 62.3% of the wild type PS, whereas the R314H and P375Q + D455Y mutants exhibited normal cofactor activity. Conclusion: These data indicate that the C80Y and R275C mutations affect the secretion and function of the PS molecule, and that the R314H and P375Q + D455Y mutations are responsible for only secretion defects, causing the phenotype of quantitative PS deficiency observed in the patients.名古屋大学博士学位論文 学位の種類:博士(医療技術学)(課程)学位授与年月日:平成19年3月23日In vitro characterization of missense mutations associated with quantitative protein Sdeficiency Schattauer, v.4, iss.9, pp.2003-2009を、博士論文として提出したもの。doctoral thesi
GEODESIC TUBES AND SPACES OF CONSTANT CURVATURE
application/pdfThis is a contribution to the general problem of how the properties of geodesic tubes on a Riemannian manifold $(M^{n}, g)$ determine the geometry of the ambient space. Using Jacobi vector fields and Fermi coordinates, we characterize spaces of constant sectional curvature by means of the shape operator of small enough geodesic tubes.departmental bulletin pape
Partially causal network inferred from the data by the method introduced in this paper – note the difference to the correlation network of Figure 1
<p><b>Copyright information:</b></p><p>Taken from "From correlation to causation networks: a simple approximate learning algorithm and its application to high-dimensional plant gene expression data"</p><p>http://www.biomedcentral.com/1752-0509/1/37</p><p>BMC Systems Biology 2007;1():37-37.</p><p>Published online 6 Aug 2007</p><p>PMCID:PMC1995222.</p><p></p> The topology of the partially causal network is identical to that of a partial correlation graph (GGM, CIG). However, edges with significant directionality (as indicated by a factor that is significantly smaller or larger than one) are oriented
Relative performance of the four investigated methods for learning VAR networks in terms of positive predictive value (true discovery rate) and the number of true and false edges
<p><b>Copyright information:</b></p><p>Taken from "Learning causal networks from systems biology time course data: an effective model selection procedure for the vector autoregressive process"</p><p>http://www.biomedcentral.com/1471-2105/8/S2/S3</p><p>BMC Bioinformatics 2007;8(Suppl 2):S3-S3.</p><p>Published online 3 May 2007</p><p>PMCID:PMC1892072.</p><p></p> The thin dotted line in the middle box at 200 corresponds to the true number of edges in the simulated networks
Undirected GGM network inferred from the data using the algorithm of 7; 9
<p><b>Copyright information:</b></p><p>Taken from "Learning causal networks from systems biology time course data: an effective model selection procedure for the vector autoregressive process"</p><p>http://www.biomedcentral.com/1471-2105/8/S2/S3</p><p>BMC Bioinformatics 2007;8(Suppl 2):S3-S3.</p><p>Published online 3 May 2007</p><p>PMCID:PMC1892072.</p><p></p> The solid and dotted lines indicate positive and negative partial correlation coefficients, respectively, and the line intensity denotes their strength
Cythara de Apolo : loas y comedias diferentes que escriuio D. Agustin de Salazar y Torres, y saca a luz D. Iuan de Vera Tasis y Villarroel...
Contiene: Elegir al enemigo (con Loa) (pp. 1-51) ; El amor más desgraciado, Zéfalo y Pocris (con Loa) (pp. 52-89) ; La mejor flor de Sicilia, Santa Rosolea (con Loa) (pp. 90-148) ; También se ama en el abismo (con Loa) (pp. 149-193) ; Los Iuegos Olympicos (con Loa) (pp. 194-238) ; El encanto es la hermosura, y el hechizo sin hechizo (con Loa) (pp. 239-290) ; El mérito es la corona, y encantos de mar y amor (con Loa) (pp. 291-343) ; Thetis y Peleo (con Loa) (pp. 344-389) ; Triunfo y venganza de amor (pp. 391-446)Mode of access: Internet
