RELAXATION HEURISTICS FOR THE SET COVERING PROBLEM

The set covering problem (SCP) is one of representative combinatorial optimization problems, which has many practical applications. The continuous development of mathematical programming has derived a number of impressive heuristic algorithms as well as exact branch-and-bound algorithms, which can solve huge SCP instances of bus, railway and airline crew scheduling problems. We survey heuristic algorithms for SCP focusing mainly on contributions of mathematical programming techniques to heuristics, and illustrate their performance through experimental analysis.journal articl

銀行の経営破綻と預金流出 －預金者による市場規律

departmental bulletin pape

Meaning of the regional field work in the class of high school : Through a questionnaire survey of high school students, collaborators

departmental bulletin pape

実習指導を行う養護教諭のための「養護実習サポートガイド」の作成と評価<教育科学>

textapplication/pdfdepartmental bulletin pape

Observation of the DsJ(2317) and DsJ(2457) in B Decays

journal articl

EXPONENTS OF SEMI-SELFSIMILAR PROCESSES

application/pdfThe exponent of a semi-selfsimilar process is shown to exist under the mere assumption of stochastic continuity at ＄t=0＄ , and related examples are given. A relationship between long range dependence of the increments and the exponent is also discussed.departmental bulletin pape

Table_1_Olive oil consumption and risk of cardiovascular disease and all-cause mortality: A meta-analysis of prospective cohort studies.DOCX

BackgroundEpidemiological studies have shown the preventive effects of olive oil consumption against cardiovascular events and all-cause deaths, but the results remain inconsistent. Herein, we performed a meta-analysis to elucidate this association.Materials and methodsA systematical literature search was conducted in online databases (PubMed and Scopus) through July 31, 2022. Prospective cohort studies providing the risk of total cardiovascular disease (CVD) or all-cause mortality for olive oil consumption were included. Relative risks (RRs) and 95% confidence intervals (CIs) were aggregated using random-effect model.ResultsThis meta-analysis included 13 studies comprising a total of 13 prospective cohorts. Compared with lower consumption, higher consumption of olive oil conferred a significantly reduced risk in CVD (RR: 0.85, 95% CI: 0.77–0.93, p ConclusionOlive oil consumption is inversely related to the risk of CVD and all-cause mortality. Such benefits seem to be obtained with an intake of olive oil up to 20 g/days, which deserves further exploration in future studies.</p

Lignan intake and risk of cardiovascular disease and type 2 diabetes: a meta-analysis of prospective cohort studies

We conducted a meta-analysis of 12 prospective cohort studies to further illuminate the associations of lignan intake with risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Compared with the lowest intake, the highest intake of lignans was correlated with a decreased incidence of CVD (relative risk [RR]: 0.85, 95% confidence interval [CI]: 0.80–0.90) and T2DM (RR: 0.82, 95% CI: 0.68–0.99). The benefits of lignan intake in CVD prevention were consistent across subgroups. In dose-response analysis, the RR for every 500-μg/d increment in lignan intake was 0.83 (95% CI: 0.74–0.92) for CVD and 0.96 (95% CI: 0.95–0.98) for T2DM. Moreover, a curvilinear dose-response pattern was observed for both CVD (p for nonlinearity p for nonlinearity < 0.001) in relation to lignan intake. These results indicated that higher lignan intake may be associated, in a dose-dependent manner, with a lower risk of CVD and T2DM.</p

DataSheet1_Osteocytes Enhance Osteogenesis by Autophagy-Mediated FGF23 Secretion Under Mechanical Tension.PDF

Mechanical stimuli control cell behaviors that are crucial for bone tissue repair. Osteocytes sense extracellular mechanical stimuli then convert them into biochemical signals to harmonize bone remodeling. However, the mechanisms underlying this process remain unclear. Autophagy, which is an evolutionarily preserved process, that occurs at a basal level when stimulated by multiple environmental stresses. We postulated that mechanical stimulation upregulates osteocyte autophagy via AMPK-associated signaling, driving osteocyte-mediated osteogenesis. Using a murine model of orthodontic tooth movement, we show that osteocyte autophagy is triggered by mechanical tension, increasing the quantity of LC3B-positive osteocytes by 4-fold in the tension side. Both in vitro mechanical tension as well as the chemical autophagy agonist enhanced osteocyte Fibroblast growth factor 23 (FGF23) secretion, which is an osteogenenic related cytokine, by 2-and 3-fold, respectively. Conditioned media collected from tensioned osteocytes enhanced osteoblast viability. These results indicate that mechanical tension drives autophagy-mediated FGF23 secretion from osteocytes and promotes osteogenesis. Our findings highlight a potential strategy for accelerating osteogenesis in orthodontic clinical settings.</p

DataSheet2_Osteocytes Enhance Osteogenesis by Autophagy-Mediated FGF23 Secretion Under Mechanical Tension.PDF

Mechanical stimuli control cell behaviors that are crucial for bone tissue repair. Osteocytes sense extracellular mechanical stimuli then convert them into biochemical signals to harmonize bone remodeling. However, the mechanisms underlying this process remain unclear. Autophagy, which is an evolutionarily preserved process, that occurs at a basal level when stimulated by multiple environmental stresses. We postulated that mechanical stimulation upregulates osteocyte autophagy via AMPK-associated signaling, driving osteocyte-mediated osteogenesis. Using a murine model of orthodontic tooth movement, we show that osteocyte autophagy is triggered by mechanical tension, increasing the quantity of LC3B-positive osteocytes by 4-fold in the tension side. Both in vitro mechanical tension as well as the chemical autophagy agonist enhanced osteocyte Fibroblast growth factor 23 (FGF23) secretion, which is an osteogenenic related cytokine, by 2-and 3-fold, respectively. Conditioned media collected from tensioned osteocytes enhanced osteoblast viability. These results indicate that mechanical tension drives autophagy-mediated FGF23 secretion from osteocytes and promotes osteogenesis. Our findings highlight a potential strategy for accelerating osteogenesis in orthodontic clinical settings.</p