中国経済の計量分析 : 東アジア開発途上国の中長期計画に対する評価・展望モデルの開発

開発計画・開発政策・開発問題の分析・評価・展望モデルとして、特に中国を対象にしてCGEモデル(Computable General Equilibrium Model)を作成し、その中国経済への応用を中心に報告書をとりまとめた。類似のモデル分析は、ベトナムを手始めに、タイ・インドネシアについても部分的に試みられている。中国経済への応用は、成長・環境・貿易自由化・地域開発に関連する諸問題の分析と展望であるが、これらの問題およびモデル分析に不可欠である生産性(TEP)の分析にも報告書のかなりの部分が充てられている。本研究の方法論的な成果は次の3点である。第1に、最新1997年の産業連関表をベースに、10〜35の産業分類で、2020年位までの長期シミュレーションに耐え得る中国経済のCGEモデルを開発した。産業分類は、環境分析の場合にはエネルギー部門を詳細にするとか、貿易自由化の分析の場合は製造業部門を細分するなど、弾力的に処理可能である。第2に、この全国モデルを2地域(四川省+その他中国)に拡張して、2地域リンクの中国CGEモデルを開発した。これを多地域リンクの中国モデルに拡張することは容易であり、地域レベルの環境問題や貿易自由化問題などの分析・展望が可能になる。第3に、以上のモデル分析に不可欠である生産性(TFP)と資本ストックを計測する新しい方法を開発した。それを全中国と30の省・直轄市・自治区に摘要し有効な結果を得た。産業への摘要は、データの制約もあり、未だ試行段階である。移行経済中国は、21世紀に向けて、(1)持続的成長の達成(2)マクロ・コントロールの実践(3)均衡のとれた地域発展という3つの大きな課題に直面している。本研究の研究課題として、中国経済が直面する上記3問題に関する総合的なCGE分析を予定している。科学研究費補助金 研究種目:基盤研究(C)(2) 課題番号:09630040 研究代表者:江崎 光男 研究期間:1997-1999年度research repor

Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann-Pick disease type C without hearing loss.

application/pdfNiemann-Pick disease type C （NPC） is a fatal disorder with abnormal intracellular cholesterol trafficking resulting in neurodegeneration and hepatosplenomegaly. A cyclic heptasaccharide with different degrees of substitution of 2-hydroxypropyl groups, 2-hydroxypropyl-β-cyclodextrin （HP-β-CD）, acts as a strong cholesterol solubilizer and is under investigation for treating this disease in clinical trials, but its physicochemical properties and ototoxicity remain a concern. Here, we evaluated the potential of mono-6-O-α-maltosyl-γ-CD （G2-γ-CD）, a single-maltose-branched cyclic octasaccharide with a larger cavity than HP-β-CD, for treating NPC. We identified that G2-γ-CD ameliorated NPC manifestations in model mice and showed lower ototoxicity in mice than HP-β-CD. To investigate the molecular mechanisms of action behind the differential ototoxicity of these CDs, we performed cholesterol solubility analysis, proton nuclear magnetic resonance spectroscopy, and molecular modeling, and estimated that the cholesterol inclusion mode of G2-γ-CD maintained solely the 1:1 inclusion complex, whereas that of HP-β-CD shifted to the highly-soluble 2:1 complex at higher concentrations. We predicted the associations of these differential complexations of CDs with cholesterol with the profile of disease attenuation and of the auditory cell toxicity using specific cell models. We proposed that G2-γ-CD can serve as a fine-tuned cholesterol solubilizer for treating NPC, being highly biocompatible and physicochemically suitable for clinical application

Studies of KCI (100) and MgO (100) Surfaces by Low Energy Electron Diffraction

departmental bulletin pape

Study of CP-Violating Asymmetries in B0→π+π- Decays

journal articl

Truncated 3-regular connected graphs are distinguishing 3-colorable

departmental bulletin pape

Zc3h6 イデンシ ノ シゼン メンエキケイ ニ オケル キノウ ノ カイメイ

奈良先端科学技術大学院大学博士(バイオサイエンス)doctoral thesi

Experimental study on the deterioration prediction of concrete structure by reliability theory

application/pdfThe prediction and evaluation of concrete service life are essential to the maintenance and durablity design concrete structures. The purpose of this study is to examine deterioration prediction of concrete structure by reliability theory to analyze data of RC model specimens during rapid freeze-thaw tests and exposure tests，large specimens during exposure tests at okhotsk shoreline， and mortal specimens during tensile strength test. These concrete durability data is assessed by reliability analysis. This analysis can predict the deterioration of concrete structures using reliability theory. From these examinations，we conclude that the Weibull distribution gives the best fit to frequency distribution of scaling that exceeds the hazard level in depth. The hazards were judged with the set-up ratio to each deterioration index. The water/cement ratio is important for covariant variable of reliability theory. When the water/cement ratio is low， the reliability is high. The service life and repair plan of RC structures can be estimated as time(year)on a index of reliability 75％，95％，etc.departmental bulletin pape

Clinico-pathological analysis of paraffin embedded supra-tentorial ependymal tumors, sub-ependymomas excluded, and of posterior fossa ependymomas presenting deletions of chromosome 9

<p><b>Copyright information:</b></p><p>Taken from "Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma"</p><p>http://www.molecular-cancer.com/content/6/1/47</p><p>Molecular Cancer 2007;6():47-47.</p><p>Published online 12 Jul 2007</p><p>PMCID:PMC1950527.</p><p></p> Tumors are divided in between trisomy 19 ependymomas and ependymomas

A) Array-CGH ideograms of the most frequently observed chromosomal anomalies in trisomy 19 ependymomas

<p><b>Copyright information:</b></p><p>Taken from "Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma"</p><p>http://www.molecular-cancer.com/content/6/1/47</p><p>Molecular Cancer 2007;6():47-47.</p><p>Published online 12 Jul 2007</p><p>PMCID:PMC1950527.</p><p></p> Blue dots: ratio between tumor DNA and control DNA; red dots: ratio between control DNA and tumor DNA. Ratio of 1 indicates normal DNA content (presence of two alleles, chromosome 2: A6). Separation of the lines corresponds to gain of tumoral DNA (blue dots going up, chromosome 19: A1, A2 and A9 and, chromosome 11: A4) or loss of tumoral DNA (blue dots going down, chromosome 13: A6 and, chromosome 9: A4). B) Scheme of array-CGH results of trisomy 19 ependymomas. Altogether 118 genetic anomalies detected, mean: 13 per tumor, consisting of 74 gains (64%) and 44 losses (36%). Numbers correspond to tumors. C) Genetic alterations presented at least in 66% (6/9) of trisomy 19 ependymomas (A1-A9) compared to two controls (Ep.: B1 and B19). Trisomy 19 observed in all cases, although in one tumor (A4) the telomeric long arm was not amplified. Deletion of 13q21.31-31.2 and deletions on chromosme 9 (M: monosomy; M: monosomy without 9qter loss; 9p: 9p deletion and Int: intertitial p and q deletions) were found in 7/9 tumors (78%). Amplification of 11q13.3-13.4 was detected in 6/9 (66%) of the tumors