Precise Measurement of B Meson Lifetimes with Hadronic Decay Final States

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連合王国の統治構造 : 特異な主権概念と不均一な権限移譲

departmental bulletin pape

Optimized parameter values for cAMP pathway full cAMP:<i>SMN2</i> model.

<p>The parameters marked with an asterisk (*) were carried over from the simplified cAMP model.</p><p>Optimized parameter values for cAMP pathway full cAMP:<i>SMN2</i> model.</p

Development of the simplified cAMP:<i>SMN2</i> model.

<p>Simplified cAMP model captures essential functions of cAMP signaling. (<b>A</b>) The original cAMP model generated by Williamson et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115473#pone.0115473-Williamson1" target="_blank">[33]</a>. (<b>B</b>) Simplified cAMP model. (<b>C</b>) Predicted concentrations of activated G proteins (GPa; blue lines), activated PKA (PKAa; green lines) and cAMP (red lines) following addition of glucose. The solid lines represent the predictions based on the simplified cAMP model while the dashed lines represent data points obtained from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115473#pone.0115473-Rolland1" target="_blank">[34]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115473#pone.0115473-Ma1" target="_blank">[35]</a>.</p

Normalized local sensitivity of gem concentration to alternate cAMP:<i>SMN2</i> model parameters.

<p>Normalized local sensitivity of gem concentration to alternate cAMP:<i>SMN2</i> model parameters.</p

Simulated treatments of SMA fibroblasts with two different cAMP modulators.

<p>Dual dose simulation data for the combination treatments with forskolin and dbcAMP (<b>A</b>), rolipram and dbcAMP (<b>B</b>) and forskolin and rolipram (<b>C</b>).</p

Relationship between Freeze Rate and Freeze-thaw Resistance of Lightweight Concrete

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Development of the full cAMP:<i>SMN2</i> model.

<p>Final gem concentrations of full cAMP:<i>SMN2</i> model (<b>A</b>) simulations (open squares) compared to experimental data (closed circles) for varying concentrations of forskolin (<b>B</b>), dbcAMP (<b>C</b>), rolipram (<b>D</b>), epinephrine (<b>E</b>) and salbutamol (<b>F</b>).</p

The effects of cAMP signaling modulators on gem counts in SMA fibroblasts.

<p>GM03813 SMA fibroblasts were treated with differing doses of dbcAMP, epinephrine, forskolin, salbutamol or rolipram for 5 days (n = 3/dose/drug). The concentrations for each dose of each drug (in µM) are shown below the appropriate bars of each graph. The vehicle for dbcAMP is ddH₂O (black bars) while DMSO (grey) serves as vehicle for the remaining compounds. The number of SMN-positive nuclear gems was counted in 100 randomly selected nuclei. Gem count analysis was also completed in GM03814 carrier fibroblasts so as to compare the gem data in treated SMA fibroblasts to those observed in healthy cells. The gem count analysis was expressed as (<b>A</b>) the number of gems per 100 nuclei, (<b>B</b>) the proportion of cells containing gems and (<b>C</b>) the proportion of cells containing multiple gems. The asterisk (*) denotes a statistically significant (p≤0.05) difference between drug-treated cells and vehicle (either ddH₂O for dbcAMP or DMSO for epinephrine, forskolin, salbutamol or rolipram)-treated cells.</p

Optimized parameter values for cAMP pathway alternate cAMP:<i>SMN2</i> model.

<p>The parameters marked with an asterisk (*) were carried over from the simplified cAMP model.</p><p>Optimized parameter values for cAMP pathway alternate cAMP:<i>SMN2</i> model.</p