クリックケミストリーにより実現する蛍光イメージング： ON/OFF制御可能なBODIPYプローブと修飾型グルコサミンの組み合わせ

宮崎大学博士（医学）2022年度doctoral thesi

A Review on Estimation of Sediment Transport and Delivary in Debris and Sediment Control Plans

departmental bulletin pape

Unusual topological RNA G-quadruplex formed by an RNA duplex: implications for the dimerization of SARS-CoV-2 RNA

The infectious disease coronavirus 2019 (SARS-CoV-2) is caused by a virus that has RNA as its genetic material. To understand the detailed structural features of SARS-COV-2 RNA, we probed the RNA structure by NMR. Two RNA sequences form a duplex and self-associate to form a dimeric G-quadruplex. The FrG nucleoside was employed as a 19F sensor to confirm the RNA structure in cells by 19F NMR. A FRET assay further demonstrated that the dimeric G-quadruplex resulted in RNA dimerization in cells. These results provide the basis for the elucidation of SARS-COV-2 RNA function, which provides new insights into developing novel antiviral drugs against SARS-COV-2.Citation: Wang S, Song Y, He Z, Saneyoshi H, Iwakiri R, Xu P, Zhao C, Qu X, Xu Y. Unusual topological RNA G-quadruplex formed by an RNA duplex: implications for the dimerization of SARS-CoV-2 RNA. Chem Commun (Camb). 2023 Oct 24;59(85):12703-12706. doi: 10.1039/d3cc03192

REAL-TIME EVALUATIONS OF TUNNEL FACES AND PREDICTIONS OF GEOLOGICAL CONDITIONS AHEAD OF THE TUNNEL FACE BASED ON DRILLING DATA

The authors developed a system for predicting the geological conditions not just of excavated areas but also ahead of the tunnel face by processing drilling data using ordinary Kriging, a geostatistical approach, and by visualizing conditions in real time. Using auto-controlled face-drilling rigs, the authors confirmed the easy and rapid acquisition of drilling data from blast holes and rock bolt holes, along with three-dimensional coordinates. The authors deployed the system in real time to determine if pre-supports such as forepoling and facebolts would be necessary for a strongly sheared slate area at the tunnel faces of the Shin-Kuzakai Tunnel (provisional name).departmental bulletin pape

Precise Measurement of B Meson Lifetimes with Hadronic Decay Final States

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研究速報 : Anisotropic Deformation and Strength Properties of Wet-Tamped Sand in Plane Strain Compression at Low Pressures (Part 4) : On Non-Linearity of Stress-Strain Relation

departmental bulletin pape

演習林生産販売品の新規開拓

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Click chemistry for fluorescence imaging via combination of a BODIPY-based ‘turn-on’ probe and a norbornene glucosamine

Citation: He Z, Ishizuka T, Hishikawa Y, Xu Y. Click chemistry for fluorescence imaging via combination of a BODIPY-based 'turn-on' probe and a norbornene glucosamine. Chem Commun (Camb). 2022 Nov 8;58(89):12479-12482. doi: 10.1039/d2cc05359d. PMID: 36278312