Cerebral radiation necrosis successfully treated with high-dose bevacizumab

Cerebral radiation necrosis (CRN) is a late complication that can occur after the treatment of a brain tumor with focal radiation therapy, particularly stereotactic radiosurgery (SRS). Since an excessive production of vascular endothelial growth factor (VEGF) from necrotic lesions is a possible etiology of radiation necrosis, the anti-VEGF antibody bevacizumab has been reported as an effective treatment option. We report a case of a 71-year-old Japanese male with CRN following SRS, successfully treated with bevacizumab. He had presented with aphasia and right lower-limb muscle weakness 6 years after a left upper lobectomy for lung adenocarcinoma. Head magnetic resonance imaging (MRI) showed a metastatic brain tumor in the left temporal lobe. A craniotomy and pre- and post-operative SRS treatments were performed to relieve his neurological symptoms. Although initial symptom improvement was observed, the patient developed lower-limb muscle weakness and aphasia symptoms 7 months after the last SRS treatment. 11C-methionine positron emission tomography (PET) and 18F-fluorodeoxyglucose PET scans showed no abnormal uptake, leading to a diagnosis of CRN. The patient was treated with bevacizumab 15 mg/kg every 3 weeks for six cycles. The bevacizumab treatment resulted in an improvement of neurological symptoms and lesions showing gadolinium-enhancing effects and high-signal areas on T2-weighted fluid attenuated inversion recovery on MRI. The improvement was maintained 44 months after the completion of the last bevacizumab treatment. Although no definitive number of cycles and dosage of bevacizumab for CRN have been established, this case suggests that administering six cycles of bevacizumab may prevent long-term recurrence of CRN

Observation of the Color-Suppressed Decay B̅ 0→D0π0

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実践哲学ノート（20）

application/pdfDie vorliegende Arbeit forscht nach dem Sinn des Menschen als menschliches Naturwesens. Der Kern des Sinnes des Menschen ist aber nichts anderes als Menschlichkeit（Humanitat）. Also behandle ich die praktische Philosophie uberhaupt, namentlich die menschliche praktische Philosophie Yoshiaki Utsunomiyas. Dabei zugleich mochte ich sein Denken selbst und auch seine Denkweise lernen. Danach mochte ich den Sinn des menschlichen Naturwesens auf Grund der Menschlichkeit （Humanitat）aufklaren und ferner den Menschen an sich selbst als systematische Totalitat der drei Lebenstatigkeiten, die aus Konsumieren, Produzieren und Verkehren bestehen, zeigen. Der Sinn des Menschen enthalt die Menschlichkeit（Humanitat）als sein ubergreifendes Moment in sich. Daher mussten wir vor allem die Menschlichkeit（Humanitat）untersuchen.departmental bulletin pape

Photochemical Reactions of 2-(4-Substituted Phenyl)-2-thiazolines : Cycloelimination of Benzonitriles and Ethylene Sulfide and Dehydrogenation to thiazoles

application/pdfUpon irradiation with UV light 2-aryl-2-thiazolines (1) yielded benzonitriles (2), ethylene sulfide (3), and 2-arylthiazoles (4) and were also reduced to 2-arylthiazolidines (5).departmental bulletin pape

研究速報 : 大気圧イオン化法（API法）によるLC/MSに関する基礎的研究

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<教育デザインフォーラム学生発表会>小学校社会科授業づくりにおける学術的連携― 教科内容研究と授業分析とに焦点づけて ―(ポスター発表の要旨)

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