29 research outputs found
Comparison of bladder inflammation in response to 10 μM of PAR1-AP in wild type (C57BL/6) and c-kit receptor deficient (Kit/Kit) mice
<p><b>Copyright information:</b></p><p>Taken from "Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation"</p><p>http://www.biomedcentral.com/1471-2172/8/17</p><p>BMC Immunology 2007;8():17-17.</p><p>Published online 17 Aug 2007</p><p>PMCID:PMC2000913.</p><p></p> A = Representative photomicrographs of H&E stained C57BL/6 urinary bladders following PAR1-AP (10 μM)-induced inflammation. PAR1-induced inflammation was characterized in C57BL/6 mice by an intense vasodilation (yellow arrows) and polymorphonuclear leukocyte infiltration (black arrows). B = absence of bladder inflammation in bladders isolated from Kit/Kitmice challenged with PAR1-AP
Lymphatic vessel density and function in experimental bladder cancer-19
<p><b>Copyright information:</b></p><p>Taken from "Lymphatic vessel density and function in experimental bladder cancer"</p><p>http://www.biomedcentral.com/1471-2407/7/219</p><p>BMC Cancer 2007;7():219-219.</p><p>Published online 29 Nov 2007</p><p>PMCID:PMC2241841.</p><p></p>apacity of the parent mice in developing bladder carcinoma (CIS) and labeling of bladder lymphatic vessels. represents X-Gal staining of bladder whole mounts isolated from SV40-mice, indicating a rich network of lymphatic vessels in the bladder adventitia. Cross-sections of the urinary bladder illustrated in were left unstained or counter stained with H&E . Figure is a representative of bladder adventitia and is a high magnification of lymphatic vessels present in the detrusor smooth muscle. Arrows () indicate the presence of β-galactosidase-positive lymphatic endothelial cells. is a representative whole mount of bladders isolated from SV40-mice subsequently stained with X-gal to reveal β-galactosidase-positive cells (blue) and LYVE-1 IHC to reveal lymphatic endothelial cells (brown). Note the complete overlap of labels confirming constitutive NF-κB activity in lymphatic vessels
Lymphatic vessel density and function in experimental bladder cancer-13
<p><b>Copyright information:</b></p><p>Taken from "Lymphatic vessel density and function in experimental bladder cancer"</p><p>http://www.biomedcentral.com/1471-2407/7/219</p><p>BMC Cancer 2007;7():219-219.</p><p>Published online 29 Nov 2007</p><p>PMCID:PMC2241841.</p><p></p>me mouse bladder represented in Figure 13 after injection of Gd-Cy5.5. A movie is illustrated in additional file
Lymphatic vessel density and function in experimental bladder cancer-16
<p><b>Copyright information:</b></p><p>Taken from "Lymphatic vessel density and function in experimental bladder cancer"</p><p>http://www.biomedcentral.com/1471-2407/7/219</p><p>BMC Cancer 2007;7():219-219.</p><p>Published online 29 Nov 2007</p><p>PMCID:PMC2241841.</p><p></p>-probe administration. . Difference image obtained at 30 minutes post-Gd-probe contrast subtracted from the pre-contrast image. This image demonstrates an early enhancement by the contrast agent into the urinary bladder extravascular space, which may be attributed to vascular leakage. . Difference image obtained at 80 minutes post-contrast subtracted from 30 minutes post-contrast. This image demonstrates a delayed enhancement due to drainage and pooling of the contrast agent, which may reflect uptake within the lymphatics in the bladder. . Difference image obtained between images in and (80 min. post-contrast minus 30 min post-contrast, and the 30 min. post-contrast minus the pre-contrast images). This image suggests that there is decreased drainage within tumorigenic areas, and perhaps a pronounced increase in uptake in the lymphatics within normal regions
Isolated frame of a movie (additional file ) presenting the visualization of high molecular weight dextran (500,000 MW)-Cy5
<p><b>Copyright information:</b></p><p>Taken from "Lymphatic vessel density and function in experimental bladder cancer"</p><p>http://www.biomedcentral.com/1471-2407/7/219</p><p>BMC Cancer 2007;7():219-219.</p><p>Published online 29 Nov 2007</p><p>PMCID:PMC2241841.</p><p></p>5 by NIRF
Representative photomicrograph of the bladder urothelium isolated from a C57BL/6 mouse challenged with PAR2-AP (10 μM)
<p><b>Copyright information:</b></p><p>Taken from "Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation"</p><p>http://www.biomedcentral.com/1471-2172/8/17</p><p>BMC Immunology 2007;8():17-17.</p><p>Published online 17 Aug 2007</p><p>PMCID:PMC2000913.</p><p></p> White circle indicates the expression of TFEB, particularly in the nucleus (DAPI-positive) of the urothelial cells
