北京オリンピック開会式テレビ中継の日中比較（下）

departmental bulletin pape

Observation of the Color-Suppressed Decay B̅ 0→D0π0

journal articl

Novel Palladium(0)-Catalyzed Coupling Reaction of Dialkoxyborane with Aryl Halides: Convenient Synthetic Route to Arylboronates

Novel Palladium(0)-Catalyzed Coupling Reaction of Dialkoxyborane with Aryl Halides:  Convenient Synthetic Route to Arylboronate

Palladium-Catalyzed Borylation of Aryl Halides or Triflates with Dialkoxyborane: A Novel and Facile Synthetic Route to Arylboronates

A direct borylation of aryl halides or triflates with dialkoxyborane was investigated. The coupling reaction of pinacolborane with aryl halides or triflates in the presence of a catalytic amount of PdCl2(dppf) together with a base provided arylboronates in high yields. The product distributions were strongly dependent on the base employed, and the tertiary amine, especially Et3N, was effective for the selective formation of the boron−carbon bond. The reaction conditions were so mild that arylboronates having a variety of functional groups such as carbonyl, cyano, and nitro groups were readily prepared

Table_1_Effect of medium-chain triglycerides supplements and walking on health-related quality of life in sedentary, healthy middle-aged, and older adults with low BMIs: a randomized, double-blind, placebo-controlled, parallel-group trial.docx

IntroductionTo extend individuals’ healthy life expectancies, the improvement of subjective health and quality of life (QOL) has been increasingly prioritized, alongside the improvement of their physical functioning. Reports have indicated that intake of medium-chain triglycerides (MCTs) benefits the physical health of older individuals requiring nursing care, and athletes, and healthy individuals. But there are few studies investigating the effects of MCTs on subjective health and QOL. The present study sought to evaluate the combined effects of 12-week MCTs supplements and moderate-intensity walking exercise on the subjective health and QOL of middle-aged and older adults aged 60–74 with low BMIs (2) and who had no exercise habits.MethodsA placebo-controlled, double-blind, parallel-group trial was conducted. Three MCTs supplement groups with different doses and fatty acid compositions were compared with a control group. The study used the SF-36v2 questionnaire to assess subjective health and health-related QOL (HRQOL).ResultsThe result showed significant improvements in the scores on subscales of the physical QOL, such as Physical functioning and General health, and summary scores on the mental QOL, compared to the control.ConclusionIt is estimated that the combination of continuous intake of MCTs and walking exercise may affect HRQOL and improve subjective physical and mental health in sedentary, healthy, middle-aged and older adults.Clinical trial registrationhttps://rctportal.niph.go.jp/s/detail/um?trial_id=UMIN000046861, UMIN000046861.</p

Combined Nondestructive Testing Method of Concrete

application/pdfThe purpose of the present paper is to obtain a practical expression for estimating the compressive strength of concrete using the nondestructive testing method combining rebound number with ultrasonic pulse velocity and to discuss its applicability to the evaluation of the strength of concrete members or structures. Experimental investigations are carried out to examine the effects of factors such as water-cement ratio, the maximum size and volume fraction of coarse aggregate, the curing condition and age of concrete. Accuracies of the prediction expressed in various types of empirical formulae are examined by multiple regression analysis, and practical equations for estimating the concrete strength are proposed. The equations are applied for evaluating the strength distribution in a concrete column and in an existing cocnrete building.departmental bulletin pape

Rhodium(I)-Catalyzed Silylation of Aryl Halides with Triethoxysilane: Practical Synthetic Route to Aryltriethoxysilanes

The specific silylation of aryl iodides and bromides with triethoxysilane (EtO)3SiH in the presence of NEt3 and a catalytic amount of [Rh(cod)(MeCN)2]BF4 provides the corresponding aryltriethoxysilanes in high yield

Substituent Effect on Reactivity of Triplet Excited State of 2,3-Diazabicyclo[2.2.1]hept-2-enes, DBH Derivatives: α C–N Bond Cleavage versus β C–C Bond Cleavage

The photoreaction of a series of 2,3-diazabicyclo[2.2.1]­hept-2-ene (DBH) derivatives, in which various substituents (X) were introduced at the methano bridge carbon of C(7), was investigated under direct (>290 nm) and triplet-sensitized (Ph₂CO, >370 nm) irradiation conditions of the azo chromophore (−C_β–C_α–NN–C_α–C_β−). The azo compounds offered a unique opportunity to see the substituent X effect at the remote position of the azo chromophore on the reactivity of the triplet excited state of bicyclic azoalkanes. The present study led to the first observation of the unusual C_α–C_β bond-cleavage reaction without the ring stiffness, that is, the structural rigidity, in the triplet state of the cyclic azoalkanes. The stereoelectronic effects were found to play an important role in lowering the activation energy of the C_α–C_β bond-cleavage reaction. NBO analyses at the M06-2X/cc-PVDZ level of theory confirmed the stereoelectronic effect

Molecular Scale Structure and Kinetics of Layer-by-Layer Peptide Self-Organization at Atomically Flat Solid Surfaces

Understanding the mechanisms of self-organization of short peptides into two- and three-dimensional architectures are of great interest in the formation of crystalline biomolecular systems and their practical applications. Since the assembly is a dynamic process, the study of structural development is challenging at the submolecular dimensions continuously across an adequate time scale in the natural biological environment, in addition to the complexities stemming from the labile molecular structures of short peptides. Self-organization of solid binding peptides on surfaces offers prospects to overcome these challenges. Here we use a graphite binding dodecapeptide, GrBP5, and record its self-organization process of the first two layers on highly oriented pyrolytic graphite surface in an aqueous solution by using frequency modulation atomic force microscopy in situ. The observations suggest that the first layer forms homogeneously, generating self-organized crystals with a lattice structure in contact with the underlying graphite. The second layer formation is mostly heterogeneous, triggered by the crystalline defects on the first layer, growing row-by-row establishing nominally diverse biomolecular self-organized structures with transient crystalline phases. The assembly is highly dependent on the peptide concentration, with the nucleation being high in high molecular concentrations, e.g., >100 μM, while the domain size is small, with an increase in the growth rate that gradually slows down. Self-assembled peptide crystals are composed of either singlets or doublets establishing P1 and P2 oblique lattices, respectively, each commensurate with the underlying graphite lattice with chiral crystal relations. This work provides insights into the surface behavior of short peptides on solids and offers quantitative guidance toward elucidating molecular mechanisms of self-assembly helping in the scientific understanding and construction of coherent bio/nano hybrid interfaces