Observation of the Color-Suppressed Decay B̅ 0→D0π0

journal articl

タンパクシツ ノ ジョウホウ コウゾウ キノウ ケンキュウ エノ ブツリガクテキ オヨビ ハクブツガクテキ アプローチ

video/mp4講演場所: バイオサイエンス研究科大講義室講演者所属: 京都大学大学院理学研究科vide

＜翻訳＞ ロラン・テヴノー（著）「規格による統治」（上）

departmental bulletin pape

The Log-Likelihood Ratio of Gamma and Lognormal Distributions Depend on the Heat Shock Parameters

<p>For 37 °C, the lognormal fits data better than the Gamma distribution. As the heat shock is increased from low to moderate, the Gamma distribution becomes a better fit. For strong heat shocks (at 44.5 °C for 30 min), there is no a clear separation between a Gamma distribution and a lognormal one.</p

Variation of Parameters <i>a</i> and <i>b</i> with Temperature and Duration of the Heat Pulse

<div><p>(A) The contours for <i>a</i> stop when <i>b</i> = 0 in the upper right region.</p><p>(B) In the lower left region, the contours for <i>b</i> stop when <i>a</i> = 0. Around 43.0 °C and duration 22 min, parameter <i>b</i> = 0.21 h⁻¹. The instability of the saddle configuration can be related to a need for sensitivity with variation in temperature and duration of the stress. Because of the double exponential law, a small variation in <i>b</i> will cause a big effect in the response to stress.</p></div

The Time Evolution of the Biological Variation in GFP

<p>As time develops, the biological heterogeneity increases. At all times, the heterogeneity is Gamma-distributed. Gamma distribution parameters <i>ρ</i> and <i>θ</i> are inserted in the legend.</p

Sixteen Pairs of (T, D) Conditions Were Run in Each Experiment

<p>For each heat shock pulse (T, D), 13 time samples were taken. At each time sample, the intensity of GFP in at least 10,000 cells was recorded. The groups A, B, and C represent weak, moderate, and strong heat shocks, respectively.</p

Experimental GFP Probability Density

<p>The experimental GFP fluorescence intensities are Gamma-distributed, as predicted by the activation–accumulation model.</p

Molecular Diagram for the Activation–Accumulation Process

<p>Molecular Diagram for the Activation–Accumulation Process</p

The Law Is the Same for All Temperatures

<div><p>(A) For weak shocks (39.5 °C to 40.5 °C), the fits are less tight than they are for moderate shocks (41.5 °C and 42.5 °C).</p><p>(B) For strong heat shocks (duration greater than 15 min in this figure), the response starts at a slow pace. Later, the response grows faster, overcoming those responses produced by less strong shocks. The time origin and the reference value for fold induction, GFP₀, is the mean response at 2 h after the shock.</p></div