12 research outputs found
A case of rapidly progressive Salmonella aortic aneurysm with acute pericarditis manifesting as a precursor
We report a case of Salmonella cardiovascular infection presenting with acute pericarditis as a precursor to the rapid progression of aortic aneurysm. An 81-year-old man presented with persistent fever and chest pain worsened with inspiration and was admitted to a nearby hospital with a diagnosis of bacterial pericarditis. However, hoarseness emerged two days later, and the patient was transferred to our hospital because of concerns about extracardiac inflammatory foci. Computed tomography (CT) revealed a periaortic exudate and aortic arch aneurysm. After transfer, blood cultures confirmed Salmonella infection. Ampicillin (ABPC) was initiated for long-term treatment of Salmonella infection, and pericarditis was treated with ibuprofen and colchicine for approximately one month. The associated symptoms and inflammatory blood data significantly improved, but five weeks later, follow-up CT revealed enlargement of the arch aneurysm. Due to the patient's age and nutritional status, thoracic endovascular aortic repair (TEVAR) was performed along with continued ABPC. Postoperatively, the infection was well-controlled, and follow-up CT revealed a size reduction in the treated aneurysm. No recurrent Salmonella-related vascular events were observed for two years after TEVAR
A case of rapidly progressive Salmonella aortic aneurysm with acute pericarditis manifesting as a precursor
We report a case of Salmonella cardiovascular infection presenting with acute pericarditis as a precursor to the rapid progression of aortic aneurysm. An 81-year-old man presented with persistent fever and chest pain worsened with inspiration and was admitted to a nearby hospital with a diagnosis of bacterial pericarditis. However, hoarseness emerged two days later, and the patient was transferred to our hospital because of concerns about extracardiac inflammatory foci. Computed tomography (CT) revealed a periaortic exudate and aortic arch aneurysm. After transfer, blood cultures confirmed Salmonella infection. Ampicillin (ABPC) was initiated for long-term treatment of Salmonella infection, and pericarditis was treated with ibuprofen and colchicine for approximately one month. The associated symptoms and inflammatory blood data significantly improved, but five weeks later, follow-up CT revealed enlargement of the arch aneurysm. Due to the patient's age and nutritional status, thoracic endovascular aortic repair (TEVAR) was performed along with continued ABPC. Postoperatively, the infection was well-controlled, and follow-up CT revealed a size reduction in the treated aneurysm. No recurrent Salmonella-related vascular events were observed for two years after TEVAR
Basal inferoseptal segment is highly susceptible to deformation in the clinical spectrum of transthyretin-derived amyloid cardiomyopathy
AIMS
While the prevalence of transthyretin-derived amyloid cardiomyopathy (ATTR-CM) is on the rise, detailed understanding of its morphological and functional characteristics within the left ventricle (LV) across heart failure (HF) remains limited.
METHODS AND RESULTS
Utilizing two-dimensional (2D) speckle-tracking echocardiography, we assessed longitudinal strain (LS) in 63 histology-confirmed ATTR-CM patients. Additionally, cardiac magnetic resonance (CMR) images measured native T1 and extracellular volume (ECV), compared with LS across 18 LV segments. Patients were categorized into three groups based on HF status: Group 1 (no HF symptoms), Group 2 (HF with preserved LV ejection fraction), and Group 3 (HF with reduced LV ejection fraction). LS analysis unveiled susceptibility to deformation in the basal inferoseptal segment, persisting even in asymptomatic cases. CMR demonstrated increasing native T1 deviation, particularly evident in segments distant from the inferoseptal region. Contrastingly, maximal ECV was consistently observed in the basal and mid-ventricular inferior-septum, even in asymptomatic individuals. Segmental LS decline correlated with ECV expansion but not with native T1 values.
CONCLUSION
Our findings suggest that the inferoseptal segment is highly susceptible to amyloid infiltration, and 2D speckle-tracking echocardiography and CMR may serve as a valuable tool for its early detection.Citation: Toshihiro Tsuruda, Hiroshi Nakada, Yoshimasa Yamamura, Yunosuke Matsuura, Miyuki Ogata, Miyo Tanaka, Yosuke Suiko, Soichi Komaki, Hiroki Tanaka, Kohei Moribayashi, Takeshi Ideguchi, Tamasa Terada, Tomomi Ota, Keisuke Yamamoto, Kensaku Nishihira, Yoshisato Shibata, Koichi Kaikita, Basal inferoseptal segment is highly susceptible to deformation in the clinical spectrum of transthyretin-derived amyloid cardiomyopathy, European Heart Journal Open, 4(5), 2024-08-31, https://doi.org/10.1093/ehjopen/oeae07
MAMs from Multiple Regression of HPD and Biological Predictors of Extinction Risk in Carnivores
MAMs from Multiple Regression of HPD and Biological Predictors of Extinction Risk in Carnivores</p
Regressions of Extinction Risk against HPD Using Phylogenetically Independent Contrasts
Regressions of Extinction Risk against HPD Using Phylogenetically Independent Contrasts</p
MAMs for Carnivore Species with Low and High Exposure to Human Populations
MAMs for Carnivore Species with Low and High Exposure to Human Populations</p
Carnivore Species Predicted to Move Most Rapidly towards Extinction by the Year 2030
<p>Species listed are those expected to move from the “low-exposure” into the “high-exposure” group (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0020197#s4" target="_blank">Materials and Methods</a> for definitions), and for which the extinction risk rating is predicted to increase by at least one index value. Bars indicate the discrepancy between current Red List rating at the left, and the predicted rating at the right. General distributions of each species are shown on the far right. Abbreviations for Red List categories: LC, least concern; NT, near threatened; CD, conservation dependent; VU, vulnerable; EN, endangered; CR, critically endangered; EW, extinct in the wild; EX, extinct.</p
