A case of rapidly progressive Salmonella aortic aneurysm with acute pericarditis manifesting as a precursor

We report a case of Salmonella cardiovascular infection presenting with acute pericarditis as a precursor to the rapid progression of aortic aneurysm. An 81-year-old man presented with persistent fever and chest pain worsened with inspiration and was admitted to a nearby hospital with a diagnosis of bacterial pericarditis. However, hoarseness emerged two days later, and the patient was transferred to our hospital because of concerns about extracardiac inflammatory foci. Computed tomography (CT) revealed a periaortic exudate and aortic arch aneurysm. After transfer, blood cultures confirmed Salmonella infection. Ampicillin (ABPC) was initiated for long-term treatment of Salmonella infection, and pericarditis was treated with ibuprofen and colchicine for approximately one month. The associated symptoms and inflammatory blood data significantly improved, but five weeks later, follow-up CT revealed enlargement of the arch aneurysm. Due to the patient's age and nutritional status, thoracic endovascular aortic repair (TEVAR) was performed along with continued ABPC. Postoperatively, the infection was well-controlled, and follow-up CT revealed a size reduction in the treated aneurysm. No recurrent Salmonella-related vascular events were observed for two years after TEVAR

A case of rapidly progressive Salmonella aortic aneurysm with acute pericarditis manifesting as a precursor

We report a case of Salmonella cardiovascular infection presenting with acute pericarditis as a precursor to the rapid progression of aortic aneurysm. An 81-year-old man presented with persistent fever and chest pain worsened with inspiration and was admitted to a nearby hospital with a diagnosis of bacterial pericarditis. However, hoarseness emerged two days later, and the patient was transferred to our hospital because of concerns about extracardiac inflammatory foci. Computed tomography (CT) revealed a periaortic exudate and aortic arch aneurysm. After transfer, blood cultures confirmed Salmonella infection. Ampicillin (ABPC) was initiated for long-term treatment of Salmonella infection, and pericarditis was treated with ibuprofen and colchicine for approximately one month. The associated symptoms and inflammatory blood data significantly improved, but five weeks later, follow-up CT revealed enlargement of the arch aneurysm. Due to the patient's age and nutritional status, thoracic endovascular aortic repair (TEVAR) was performed along with continued ABPC. Postoperatively, the infection was well-controlled, and follow-up CT revealed a size reduction in the treated aneurysm. No recurrent Salmonella-related vascular events were observed for two years after TEVAR

Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome

Objective The primary care for acute coronary syndrome (ACS) includes the administration of nitroglycerin (GTN). This study aimed to investigate the association between the use of GTN before percutaneous coronary intervention (PCI) for ACS and clinical outcomes. Methods Nine-hundred and forty-seven patients who underwent PCI for ACS were examined and classified into two groups: those who were treated with GTN before PCI (GTN group) and those who were not (non-GTN group). The incidence of major adverse cardiovascular events (MACE), which consist of all-cause mortality, non-fatal myocardial infarction, stroke and rehospitalisation for heart failure at 1 year, was compared between the two groups. Results This study identified 289 patients with ACS who used GTN preceding PCI. Pre-PCI systolic blood pressure was significantly lower in the GTN group than in the non-GTN group (median (IQR); 132.0 (110.0–143.5) mm Hg vs 134.0 (112.0–157.0) mm Hg, respectively, p=0.03). Multivariate Cox regression analysis indicated that GTN use preceding PCI showed an independent association with the incidence of MACE (HR 1.57; 95% CI 1.09–2.28; p=0.016). Overall, the incidence of MACE 1 year after PCI for ACS was significantly higher in the GTN group than in the non-GTN group (log-rank test, p=0.024); however, this trend was consistently found in elderly patients aged ≥75 years (p=0.002) but not in non-elderly patients aged <75 years (p=0.773). Conclusions GTN use preceding PCI for ACS is associated with lower blood pressure and adverse clinical outcomes in elderly patients.Citation: Soichi Komaki, Yunosuke Matsuura, Hiroki Tanaka, Kohei Moribayashi, Yoshimasa Yamamura, Kazumasa Kurogi, Takeshi Ideguchi, Nobuyasu Yamamoto, Michikazu Nakai, Toshihiro Tsuruda, Koichi Kaikita, Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome. Open Heart. 2024-01, 11(1), e002494, https://doi.org/10.1136/openhrt-2023-00249

Basal inferoseptal segment is highly susceptible to deformation in the clinical spectrum of transthyretin-derived amyloid cardiomyopathy

AIMS While the prevalence of transthyretin-derived amyloid cardiomyopathy (ATTR-CM) is on the rise, detailed understanding of its morphological and functional characteristics within the left ventricle (LV) across heart failure (HF) remains limited. METHODS AND RESULTS Utilizing two-dimensional (2D) speckle-tracking echocardiography, we assessed longitudinal strain (LS) in 63 histology-confirmed ATTR-CM patients. Additionally, cardiac magnetic resonance (CMR) images measured native T1 and extracellular volume (ECV), compared with LS across 18 LV segments. Patients were categorized into three groups based on HF status: Group 1 (no HF symptoms), Group 2 (HF with preserved LV ejection fraction), and Group 3 (HF with reduced LV ejection fraction). LS analysis unveiled susceptibility to deformation in the basal inferoseptal segment, persisting even in asymptomatic cases. CMR demonstrated increasing native T1 deviation, particularly evident in segments distant from the inferoseptal region. Contrastingly, maximal ECV was consistently observed in the basal and mid-ventricular inferior-septum, even in asymptomatic individuals. Segmental LS decline correlated with ECV expansion but not with native T1 values. CONCLUSION Our findings suggest that the inferoseptal segment is highly susceptible to amyloid infiltration, and 2D speckle-tracking echocardiography and CMR may serve as a valuable tool for its early detection.Citation: Toshihiro Tsuruda, Hiroshi Nakada, Yoshimasa Yamamura, Yunosuke Matsuura, Miyuki Ogata, Miyo Tanaka, Yosuke Suiko, Soichi Komaki, Hiroki Tanaka, Kohei Moribayashi, Takeshi Ideguchi, Tamasa Terada, Tomomi Ota, Keisuke Yamamoto, Kensaku Nishihira, Yoshisato Shibata, Koichi Kaikita, Basal inferoseptal segment is highly susceptible to deformation in the clinical spectrum of transthyretin-derived amyloid cardiomyopathy, European Heart Journal Open, 4(5), 2024-08-31, https://doi.org/10.1093/ehjopen/oeae07

Production of Prompt Charmonia in e+e- Annihilation at sqrt[s] ≈ 10.6 GeV

journal articl

国際民事訴訟の現状(解題)

2010-03-25departmental bulletin pape

サイボウ キノウ オ ノゾク ブンシ デザイン

video/mp4講演場所: 物質創成科学研究科大講義室講演者所属: 大阪大学大学院工学研究科教授vide

Ulitaprecision Machining Characteristics of Poly-Crystalline Germanium

Germanium is an excellent infrared optical material. 0n most occasions, singlecrystalline germanium is used as optical lens substrate because its homogeneous structure is beneficial for fabricating uniform optical surfaces.　In this work, we attempt to use poly crystals as lens substrates instead of single crystals, which may lead to a significant reduction in production cost. We conducted ultraprecision cutting experiments on poly-crystanine germanium to examine the microscopic machinability. The crystal orientations of specific crystal grains were characterized, and the machining characteristics of these crystal grains including surface textures, cutting forces, and grain boundary steps were investigated under various machining conditions. It was possible to produce uniformly ductile-cut surfaces cross all crystal grains by using an extremely small undeformed chip thickness (～80nm)under negative tool rake angles (～－45°).This work indicates the possibility of fabricating high-quality infrared optical components from poly-crystalline germanium.journal articl

Vida i maravillosas virtudes de Doña Sancha Carrillo ... /

Contiene con portada propia "Vida de Doña Ana Ponce de León, condesa de Feria", en h. 51-124.Mode of access: Internet.Colofón en h. Q4Es posible que se trate de un ejemplar falto de la primera parte de la obra, "Flos sanctorum, fiestas i santos naturales de la ciudad de Cordova ..."Es emisión de la segunda parte de la obra "Flos sanctorum, fiestas i santos naturales de la ciudad de Cordova ..." impresa en Sevilla por Alonso Rodríguez Gamarra en 1615 (Palau, 270583). Tiene la misma portada y texto pero la tipografía y signaturas del primer cuaderno que contiene los preliminares son diferente y existen pequeñas variantes textuales.Texto con doble fileteado y con apostillas marginales.Errores de foliación, de h. 98 pasa a 102.Portada con escudo xilográfico de la Compañía de Jesús.Sign.: []5, A-P8, Q4

Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome

Objective The primary care for acute coronary syndrome (ACS) includes the administration of nitroglycerin (GTN). This study aimed to investigate the association between the use of GTN before percutaneous coronary intervention (PCI) for ACS and clinical outcomes. Methods Nine-hundred and forty-seven patients who underwent PCI for ACS were examined and classified into two groups: those who were treated with GTN before PCI (GTN group) and those who were not (non-GTN group). The incidence of major adverse cardiovascular events (MACE), which consist of all-cause mortality, non-fatal myocardial infarction, stroke and rehospitalisation for heart failure at 1 year, was compared between the two groups. Results This study identified 289 patients with ACS who used GTN preceding PCI. Pre-PCI systolic blood pressure was significantly lower in the GTN group than in the non-GTN group (median (IQR); 132.0 (110.0–143.5) mm Hg vs 134.0 (112.0–157.0) mm Hg, respectively, p=0.03). Multivariate Cox regression analysis indicated that GTN use preceding PCI showed an independent association with the incidence of MACE (HR 1.57; 95% CI 1.09–2.28; p=0.016). Overall, the incidence of MACE 1 year after PCI for ACS was significantly higher in the GTN group than in the non-GTN group (log-rank test, p=0.024); however, this trend was consistently found in elderly patients aged ≥75 years (p=0.002) but not in non-elderly patients aged <75 years (p=0.773). Conclusions GTN use preceding PCI for ACS is associated with lower blood pressure and adverse clinical outcomes in elderly patients.Citation: Soichi Komaki, Yunosuke Matsuura, Hiroki Tanaka, Kohei Moribayashi, Yoshimasa Yamamura, Kazumasa Kurogi, Takeshi Ideguchi, Nobuyasu Yamamoto, Michikazu Nakai, Toshihiro Tsuruda, Koichi Kaikita - Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome: Open Heart 2024;11:e002494