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departmental bulletin pape

Clinical Experience With Preventing Chemotherapy-Induced Neutropenia in Breast Cancer Patients With Different Timings of Pegylated Granulocyte Colony-Stimulating Factor (PEG-G-CSF) Injection: A Case Series

Pegfilgrastim (pegylated granulocyte colony-stimulating factor, PEG-G-CSF) is commonly used as prophylaxis for febrile neutropenia (FN) in high-risk chemotherapy regimens for breast cancer. However, the optimal timing of PEG-G-CSF injections has not been established, despite several investigations into the subject. In this study, patients received epirubicin-based breast cancer chemotherapy and underwent routine blood tests on days seven or eight of initial chemotherapy to assess the risk of FN. Four patients experienced significant decreases in white blood cell (WBC) and neutrophil (NE) counts. To maintain patient safety and relative dose intensity (RDI), the dose was reduced in the second cycle, and PEG-G-CSF administration was moved from day three to day four, as administering PEG-G-CSF within 24 hours to prevent FN is thought to be ineffective. This theory is based on the fact that the WBC and NE expanded by PEG-G-CSF were killed by the remaining chemotherapy. Therefore, we hypothesized that in the next second cycle, administering PEG-G-CSF one day later (day four) after chemotherapy might be effective for these patients. Furthermore, for patients whose blood tests on days seven or eight of the second cycle showed an increase in WBC and NE counts, the chemotherapy dose was increased in the third cycle. Patients with breast cancer (age range: 41-71 years) were assigned to receive PEG-G-CSF on day three or four of a three-week epirubicin and cyclophosphamide-based chemotherapy regimen (dose-dense epirubicin and cyclophosphamide; 5-fluorouracil, epirubicin, and cyclophosphamide; or basic epirubicin and cyclophosphamide) using heterochronic timing. We then compared WBC and NE counts in the same individuals over time. In all four cases, WBC and NE counts on day seven or eight were much greater with PEG-G-CSF injection on day four than with injection on day three. As per heterochronic follow-up, which has not been reported previously, day four injection of PEG-G-CSF appears more effective than day three injection for preventing neutropenia. However, due to the small number of cases in this series and the confounding factor of the chemotherapy dose in the third cycle being approximately 8% less than that in the first cycle in Case 2, it is difficult to generalize our findings. Hence, future studies with a longitudinal follow-up involving a larger number of cases are required

Piezoelectric Strain Control of Terahertz Spin Current

Electrical control of photogenerated terahertz (THz) spin current pulses from a spintronic emitter has been at the forefront for the development of scalable, cost-efficient, wideband optospintronic devices. Artificially combined ferroelectric and ferromagnet heterostructure provides the potential avenue to deterministically control the phase of THz spin current pulse through piezoelectric strain. Here, the electric field-mediated piezoelectric strain control of photogenerated THz spin current pulse from a multiferroic spintronic emitter is demonstrated. The phase reversal of the THz spin current pulse is obtained from the combined effect of piezoelectric strain and a small magnetic field applied opposite to the initial magnetization of the ferromagnet. The piezoelectric strain-controlled phase switching of THz spin current thus opens a door to develop efficient strain engineered scalable on-chip THz spintronics devices.journal articl

Production of Prompt Charmonia in e+e- Annihilation at sqrt[s] ≈ 10.6 GeV

journal articl

ハンドウタイ ナノ コウゾウ ニ オケル ジキ コウガク コウカ

video/mp4講演場所: 物質創成科学研究科大講義室講演者所属: 甲南大学理工学部vide

The development of a reentry circuit due to slowed action potential velocity.

<p>Increased expression of Tnni3k (and downstream targets) slows conduction velocity of the propagating action potential. Slowed conduction, in turn, favors the formation of stable reentrant propagation, a common mechanism for sustained arrhythmia.</p

特集13 : 研究速報 : 自動車室内の空調気流に関する数値シミュレーション

特集 乱流の数値シミュレーション（NST） その7departmental bulletin pape

Unified Constitutive Equations in Polycrystal Finite Element Model

application/pdfThe finite element method (FEM) is a very powerful device for solving many continuum mechanics problems which can be treated neither theoretically nor experimentally. In this paper FEM is developed for an analysis of semimicroscopic effects within inelastically deformed polycrystalline metals and their collective action to its macroscopic response.departmental bulletin pape

Basal Isus I-V curves (A) and RSD-sensitive Isus I-V curves (B) in NZPCs and IZPCs.

<p>The density of the basal Isus differed significantly between the NZPCs and IZPCs for all Vt>−40 mV. There was no significant difference in the RSD-sensitive Isus density between NZPCs and IZPCs.</p

Immunolocalization of cortactin and N-cadherin in an NZPC (A) and several IZPCs (B, C and D).

<p>Horizontal scale = 10 µm.</p