スポーツの正義と創造

departmental bulletin pape

Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytology

Summary Spindle epithelial tumor with thymic-like elements (SETTLE) is an extremely rare tumor that occurs primarily in the thyroid gland. Histologically, SETTLE is characterized by the presence of spindle-shaped epithelial cells and glandular structures. However, it is known that diagnosis via fine-needle aspiration cytology can be challenging. SETTLE predominantly occurs in younger individuals and has a less favorable prognosis compared to differentiated thyroid carcinoma. Therefore, ensuring accurate diagnosis and appropriate treatment is crucial. We encountered a case of spindle epithelial tumor with thymus-like differentiation in a 10-year-old patient for whom the preoperative diagnosis was successfully established through fine-needle aspiration cytology, which facilitated appropriate surgical resection. Comprehensive histopathological examination and immunohistochemical analysis are essential to ensure appropriate management and surveillance of SETTLE. Learning points A rare thyroid tumor, spindle epithelial tumor with thymic-like elements (SETTLE), was diagnosed preoperatively and treated surgically. SETTLE presents with characteristic histological features that must be recognized for accurate diagnosis. In addition, diagnosis through cytology is often challenging. The primary treatment for SETTLE is surgical intervention as radiotherapy and pharmacological treatments are generally not expected to be highly effective. Radical resection is the only effective treatment, making the selection of the surgical procedure according to the stage of the disease essential

Production of Prompt Charmonia in e+e- Annihilation at sqrt[s] ≈ 10.6 GeV

journal articl

コタイ ニ オケル THz リョウイキ ノ センケイ ヒセンケイ ブンコウ

video/mp4テラヘルツ(THz)周波数帯には、誘電体のソフトモードや超伝導ギャップ、励起子系の内部遷移など物性を決定づける素励 起がみられる。近年、超短光パルスの波長変換技術による高強度、広帯域のテラヘルツ波発生と電場の実時間波形計測技術が確立したことで、 THz領域の線形・非線形分光が様々な物質で行われてきた。ここでは電子系として半導体、格子系として誘電体に注 目し、THz 領域における線形、非線形分光で何が明らかになるかについて紹介する。講演者所属: 大阪大学大学院基礎工学研究科物質創成専攻未来物質領域講演日: 平成24年11月8日講演場所: 物質創成科学研究科大講義室vide

Reactivation of PFV-Infected Resting Cells

<div><p>(A) Sub-cellular localization of Gag proteins (green) studied by confocal microscopy following indirect immunofluorescence using anti-Gag antiserum. Thirty days p.i., Gag proteins mainly localize at the MTOC (stained with anti-γ-tubulin abs in red) in resting cells. In contrast, Gag proteins are detected both in the cytoplasm and the nucleus of these cells at 24, 48, and 96 h post-activation by splitting and serum addition. Syncitia, characteristic of a productive FV infection, appear 96 h post-reactivation.</p><p>(B) Western blot analysis of protein extracts from resting and activated PFV-infected cells with or without CHX treatment (150 μg/ml). At 30 d p.i. (with m.o.i. of 2), only the Gag doublet at 68 and 71 kDa is detected in resting cells using anti-Gag abs. Under CHX treatment, at 24 h post-reactivation, Gag cleavages are clearly detected, including the 38-kDa Gag product (*) involved in virus uncoating [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.0030074#ppat-0030074-b020" target="_blank">20</a>].</p></div

Characterization of Incoming PFV Particles in Resting MRC5 Cells

<div><p>(A) Electron micrographs of uninfected and infected cycling and resting cells. Normally shaped intracellular capsids (pointed out by a black arrow) are observed in PFV-infected cycling cells at 4 h p.i. In resting cells at 5 or 15 d p.i., similar intact capsids (pointed out by a black arrow) are observed surrounding the MTOC. High magnifications are presented in the right corner. No viral capsids are detected in uninfected cells.</p><p>(B) Western blot analysis of protein extracts from PFV-infected cycling and resting cells using anti-Gag abs. Analysis of protein lysates performed 7 h p.i. in cycling cells reveals the presence of the characteristic Gag doublet (71–68 kDa) and early Gag cleavage products. The 38-kDa Gag product (*) results from the action of the viral protease. In resting cells, 5 or 15 d p.i., these shorter Gag products are absent.</p></div

Intracellular Localization of Incoming PFV in Quiescent and Activated CD4-positive T Cells

<div><p>(A) Flow cytometry profile of isolated human resting CD4-positive T cells. Purity of sorted cells is at least 99% and no cell activation is observed 5 d p.i.</p><p>(B) Sub-cellular localization of Gag proteins studied by confocal microscopy following indirect immunofluorescence using anti-Gag antiserum (green). In activated CD4-positive T cells at 48 h p.i., Gag proteins are not restricted to the MTOC but diffusely localize in the cytoplasm and in the nucleus (top row). In resting CD4-positive T cells at 2 and 5 d p.i., Gag proteins co-localize with γ-tubulin (red), the MTOC marker. Twenty-four hours following cell stimulation of 5 d−infected resting CD4-positive T cells, Gag proteins diffusely localize in the cytoplasm and in the nucleus, similar to what we observed in activated CD4-positive T cells (bottom row).</p></div

Supplementary Data from Distinct p53 Gene Signatures Are Needed to Predict Prognosis and Response to Chemotherapy in ER-Positive and ER-Negative Breast Cancers

Supplementary Figures S1-S5; Supplementary Methods; Supplementary Tables S1-S6.</p

Intracellular Localization of Incoming PFV in Resting MRC5 Cells

<div><p>(A) Sub-cellular localization of incoming Gag proteins studied by confocal microscopy following indirect immunofluorescence at 3, 15, and 30 d p.i. using anti-Gag antiserum (green). At these time points, Gag is exclusively detected at the MTOC, stained with γ-tubulin abs (red). Nuclei are stained with DAPI (blue).</p><p>(B) Sub-cellular localization of the viral DNA genome from incoming PFV analyzed by confocal microscopy following in situ hybridization 15 d p.i. using a biotin-labeled PFV full-length probe (green). As well as incoming Gag, the viral DNA genome localizes at the MTOC (revealed with anti-γ-tubulin abs, red) 15 d p.i. Nuclei are stained with DAPI (blue).</p></div

Additional file 1 of Arsenic trioxide (As2O3) as a maintenance therapy for adult T cell leukemia/lymphoma

Additional file 1: Table S1. Toxicity