Production of Prompt Charmonia in e+e- Annihilation at sqrt[s] ≈ 10.6 GeV

journal articl

Photodissociation of Simple Molecules in the Gas Phase Supplement IX

application/pdfThis is the ninth supplement to the review "Photodissociation of Simple Molecules in the Gas Phase" which appeared in Vol.11 of the Research Reports (1986), hereafter called the Main Review. Supplements I-VIII appeared in Vol.12 (1987)-19 (1994), respectively. Continuing effort has been taken to collect new papers related to the title subject approximately up to July 1995. Some papers before July 1994 which have been inadvertently eluded from the Main Review and Supplements I-VIII are added. The style closely follows those of the Main Review and Supplements I-VIII. A book, "Photodissociation of Simple Molecules in the Gas Phase", a collected version of the Main Review and Supplements I-V (and a part of the Supplement VI) is available from Bunshin Publishing, Co., Tokyo.departmental bulletin pape

デンシ トショ ノ エツラン

video/mp4vide

Safety and Effectiveness of Ipragliflozin for Type 2 Diabetes in Japan: 12-Month Interim Results of the STELLA-LONG TERM Post-Marketing Surveillance Study

Full copyright for enhanced digital features is owned by the authors. Article full text The full text of this article can be found here. Provide enhanced digital features for this article If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact [email protected]. The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. Other enhanced features include, but are not limited to: • Slide decks • Videos and animations • Audio abstracts • Audio slides</p

Safety and efficacy of ipragliflozin in elderly versus non-elderly Japanese patients with type 2 diabetes mellitus: a subgroup analysis of the STELLA-LONG TERM study

<p><b>Background</b>: This subgroup analysis of STELLA-LONG TERM interim data explored the long-term safety and efficacy of ipragliflozin in non-elderly vs. elderly Japanese type 2 diabetes mellitus (T2DM) patients.</p> <p><b>Research design and methods</b>: STELLA-LONG TERM is an ongoing 3-year prospective surveillance study of Japanese T2DM patients receiving ipragliflozin 50 mg once daily. In this subgroup analysis, patient characteristics, laboratory variables, and adverse drug reactions (ADRs) were compared between non-elderly (<65 years) and elderly (≥65 years) patients.</p> <p><b>Results</b>: Non-elderly patients had significantly higher body mass index and low-density lipoprotein cholesterol than elderly patients (<i>P </i>< 0.001). The proportion of patients with hemoglobin A1c (HbA1c) <8.0% was significantly higher among elderly patients (<i>P </i>< 0.001). HbA1c, fasting plasma glucose, and body weight significantly decreased from baseline to 3 and 12 months in both groups (all <i>P </i>< 0.05 vs. baseline). The ADR incidence was 10.83% vs. 10.42% in non-elderly and elderly patients. The incidence of skin complications was 0.98% vs. 1.65% and that of renal disorder was 0.47% vs. 0.95% in non-elderly and elderly patients (both <i>P </i>= 0.003).</p> <p><b>Conclusions</b>: Ipragliflozin was effective in non-elderly and elderly Japanese T2DM patients in a real-world clinical setting. The incidence of renal disorder and skin complications was significantly higher in elderly vs. non-elderly patients.</p

NAD level is not changed even in the aged Nmnat3 KO mice.

<p>(A-C) Semi-quantification of NAD levels in liver (A), skeletal muscle (B) and red blood cells (C) from 21-month-old WT and Nmnat3 KO mice. Data are presented as mean ± SD (n = 4 for each group). (D) Spleen weight was calculated using 21-month-old WT and Nmnat3 KO mice (n = 4 for each group). (D and E) Hematoxylin-Eosin (HE) staining of liver (D) and skeletal muscle (E) sections prepared from 21-month-old WT and Nmnat3 KO mice. Scale bar represents 200μm.</p

Nmnat3 partially contributes to the Nmnat activity in mitochondria.

<p>(A) Subcellular fractionation of endogenous Nmnat3 protein in skeletal muscle. GAPDH was used as a cytoplasmic fraction marker, and GRP75 (mitochondrial HSP70) was used as a mitochondrial fraction marker. (B and C) Nmnat activities of total tissue lysates from liver (B) and skeletal muscle (C) were measured by enzymatic activity assay. For this assay, tissue lysates were prepared from WT and Nmnat3 KO mice. Samples were dialyzed to remove endogenous metal ion and metabolites. Data are presented as mean ± SD (n = 4 for each group). (D and E) Mitochondrial Nmnat activities from liver (B) and skeletal muscle (C) were also measured in the same way as above. (F and G) Ratio of Nmnat activity in mitochondria against that in whole cell from WT liver (F) and WT skeletal muscle. Data are presented as mean ± SEM (n = 3 for each group).</p

Nmnat1 and Nmnat2 are not up-regulated in Nmnat3 KO mice.

<p>(A-C) Real-time quantitative PCR analysis for mRNA level of Nmnat1, Nmnat2 and Nmnat3. Total RNA was isolated from liver (A), skeletal muscle (B) and heart (C) of WT and Nmnat3 KO mice. <i>Rpl13a</i> gene was used as a reference gene, and data are presented as a relative value to WT for each gene (n = 4 for each group).</p

Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines

<div><p>The inhibition of DNA damage response pathway seems to be an attractive strategy for cancer therapy. It was previously reported that in rodent cells exposed to heat stress, cell growth was promoted by the activity of DNA-dependent protein kinase (DNA-PK), an enzyme involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. The absence of a functioning DNA-PK was associated with down regulation of heat shock protein 70 (HSP70). The objective of this study is thus to investigate the role of DNA-PK inhibition in heat-induced apoptosis in human cell lines. The inhibitors of phosphorylation of the DNA-PK catalytic subunit (DNA-PKcs) at Ser2056, such as NU7026 and NU7441, were utilized. Furthermore, knock down of DNA-PKcs was carried out using small interfering RNA (siDNA-PKcs). For heat exposure, cells were placed in water bath at 44°C for 60 min. Apoptosis was evaluated after 24 h incubation flow cytometrically. Proteins were extracted after 24 h and analyzed for HSP70 and HSP40 expression by Western blotting. Total RNA was extracted 6 h after treatment and analyzed using a GeneChip® microarray system to identify and select the up-regulated genes (≥1.5 fold). The results showed an enhancement in heat-induced apoptosis in absence of functioning DNA-PKcs. Interestingly, the expression levels of HSP70 and HSP40 were elevated in the absence of DNA-PKcs under heat stress. The results of genetic network analysis showed that HSPs and JUN genes were up-regulated independently of DNA-PKcs in exposed parent and knock out cells. In the presence of functioning DNA-PKcs, there was an observed up-regulation of anti-apoptotic genes, such as NR1D1, whereas in the absence of DNA-PKcs the pro-apoptotic genes, such as EGR2, were preferentially up-regulated. From these findings, we concluded that in human cells, the inactivation of DNA-PKcs can promote heat-induced apoptosis independently of heat-shock proteins.</p> </div

The glycolysis pathway and TCA cycle were normally maintained in Nmnat3 KO mice.

<p>Metabolites in glycolysis pathway (A and B) and TCA cycle (C-H) were measured by SIM mode operated-GC/MS using skeletal muscle samples from 5-month-old WT and Nmnat3 KO mice (n = 4 for each group). Metabolites measured by GC/MS included pyruvate (A), lactate (B), isocitric acid/ citric acid (C), aconitic acid (D), oxaloacetic acid (E), fumaric acid (F), succinic acid (G), and malic acid (H). Data are presented as mean ± SD (n = 4 for each group). (I and J) Levels of ATP (I) and AMP (J) in skeletal muscle were measured by LC/MS. Data are presented as mean ± SD (n = 4 for each group).</p