溶湯法ポーラスアルミニウムの気孔制御および衝撃圧縮特性に関する研究

名古屋大学Nagoya University博士(工学)名古屋大学博士学位論文 学位の種類 : 博士(工学)(課程) 学位授与年月日 : 平成21年10月30日doctoral thesi

Observation of B+ → χc0K+

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Generation and Characterization of Motor Neuron Progenitors and Motor Neurons Using Metachromatic Leukodystrophy-Induced Pluripotent Stem Cells

video/mp4期間:2022年10月14日講義場所: 研修ホールvide

Introduction et Developpement des Cercles de Qualite au Japon

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気象条件に着目した道路利用者費用に関する一考察

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AIQ decreases CIA severity.

<p>DBA1 mice with established CIA were injected i.p. either with PBS (control) or with AIQ (1.5 mg/kg) on day 22 or on day 25. A. Severity of arthritis was assessed by clinical scoring. Numbers in parenthesis represent frequency of arthritis (% mice with arthritis score>2 at day 35). B. Histological analysis of trichromic-stained (lower) or H&E-stained (upper) sections of joints obtained at day 45 was performed. Scoring of inflammation, cartilage damage and bone erosion of paws from untreated (control) and AIQ-treated CIA mice is shown. Neutrophil infiltration in the joints was determined by measuring MPO activity in protein extracts isolated at day 35. n = 6–8 mice per group. *p<0.001 versus control.</p

Inhibition of PARP-1 downregulates Th1-mediated response in CIA.

<p>DBA1 mice with established CIA were injected i.p. either with PBS (control) or with AIQ (1.5 mg/kg) on day 25 post-immunization. A. Proliferative response and cytokine production of DLN cells isolated at day 30 from untreated (control) or AIQ-treated CIA mice were determined after in vitro stimulation with different concentrations of CII. Stimulation of DLN cells with anti-CD3 antibodies (▾, for untreated CIA mice; ▿, for AIQ-treated CIA mice) was used for assessment of nonspecific stimulation. A pool of 3 nonimmunized DBA/1 DLN cells was used for assessment of the basal response. No proliferation or cytokine production by T cells was detectable in the presence of an unrelated antigen (OVA). n = 5 mice/group. B, Number of CII-specific cytokine-producing T cells. DLN cells from untreated (control) or AIQ-treated CIA mice were restimulated in vitro with CII (10 µg/ml) and analyzed for CD4 and intracellular cytokine expression in gated CD4 T cells by flow cytometry. Dot plots show representative double staining for IFNγ/TNFα or IL-4/IL-10 expression in gated CD4 T cells. The number of IFNγ-, IL-4- and IL-10-expressing T cells relative to 10⁴ CD4 T cells is shown in the lower panel. Data shown represent pooled values from two independent experiments. C, CII-specific proliferative response and the number of cytokine-producing CD4 T cells were determined in synovial membrane cells isolated from untreated (control) or AIQ-treated CIA mice and stimulated in vitro with CII (10 µg/ml) for 48 h. Data show the results of pooled synovial cells from 3 animals per group. D. AIQ decreases titter of autoantigens in CIA mice. The levels of CII-specific IgG, IgG1 and IgG2a antibodies in sera collected at day 35 were determined by ELISA. n = 3-5 mice/group. *p<0.001 versus controls.</p

AIQ administration inhibits inflammatory response in CIA.

<p>DBA1 mice with established CIA were injected i.p. either with PBS (control) or with AIQ (1.5 mg/kg) on day 25 post-immunization. Systemic and local expression of inflammatory mediators was assayed in protein extracts from joints (A) and sera (B) isolated at day 35 post-immunization. A paw from an unimmunized mouse was analyzed simultaneously for assessment of the basal response. n = 3–4 mice/group. *p<0.001 versus controls.</p

Karyotype Variation in Japanese and Chinese Common Wheat

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