批判的実在論と“社会”概念［2］ : 社会学における間 : 専門性へと関わらせて

departmental bulletin pape

Measurement of Branching Fractions for B → ππ, Kπ, and KK Decays

journal articl

A Note on the Wild Boy "Tissa"

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Real-time aerosol chloride deposition measuring device using a conductivity sensor

This study proposes a new monitoring method to measure real-time aerosol chloride deposition. The concept of a water candle device is introduced, and the device is manufactured. By continuously generating a thin water film in combination with a conductivity sensor, the device is capable of measuring aerosol chloride deposition in all directions and has a compact design. The water candle device was fully tested in the laboratory and applied to monitor on a bridge. For the laboratory tests, the transport of aerosol in an area near the seashore was simulated to evaluate the accuracy and responsiveness of the device according to the variable wind speed and source salt concentration. For monitoring in the field, the device was implemented at the Thuan Phuoc Bridge, Vietnam, for seven days with a short recording frequency of a few hours. A set of wet candle devices were placed next to the water candle device to compare the results of the two methods. The results of the laboratory test and field monitoring demonstrated a high accuracy and responsiveness of the water candle device to variations in the wind speed and salt concentration of the source. Further, there were only very small differences between the results from the wet and water candle devices.journal articl

The Tsk-1 model of cutaneous fibrosis exhibits increased MAGP-2, loss of fibulin-5 and increased fibulin-2 matrix

<p><b>Copyright information:</b></p><p>Taken from "Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions"</p><p>http://arthritis-research.com/content/9/S2/S4</p><p>Arthritis Research & Therapy 2007;9(Suppl 2):S4-S4.</p><p>Published online 15 Aug 2007</p><p>PMCID:PMC2072888.</p><p></p> Tissue sections from tight skin (Tsk) mice (panels 1 and 3) and control (panels 2 and 4) mice were immunostained for microfibril-associated glycoprotein (MAGP)-2. MAGP-2 is indicated by arrowheads. MAGP-2 was detected at higher levels in all dermal layers (panel 1 versus panel 2). Hypodermis (H) is shown (panel 3 versus panel 4). PC, panniculus carnosus; D, dermis. Control (left panel) and Tsk (right panel) mice skin sections from 6-week-old mice were stained in parallel for fibulin-5 by immunohistochemistry. Positive staining is indicated by arrows at the muscle-connective tissue (M-CT) interface. Hypodermal connective tissue (HD) and hypodermal muscle (M) are indicated. Original magnification: 400×. Control (panels 1 and 3) and Tsk (panels 2 and 4) mouse skin sections from 6-week-old mice were stained in parallel for fibulin-2 by immunohistochemistry. Positive staining is indicated by arrows (M-CT interface) and in panel 4 around hair follicles (F). (a) Reproduced with permission from Lemaire 2004 John Wiley & Sons/American College of Rheumatology [18]. (b) and (c) Reproduced with permission from [19]

Reflective properties of natural snow: approximate asymptotic theory versus in situ measurements

journal articl

Epithelial and mesenchymal markers in SSc skin.

<p>(A) Representative images of double immunofluorescent staining of forearm skin sections performed to detect basement membrane protein collagen IV (red) and mesenchymal cell marker FSP-1 (green). The basement membrane collagen IV was not seen to be compromised in SSc, whereas some abnormal expression of FSP-1 in keratinocytes was seen in the SSc sections. (B) Additional stains for E-cadherin (green) and vimentin (red) were performed showing no loss of E-cadherin in SSc epidermal cells. Some expression of vimentin was however observed in the SSc epidermis. (C)Further analysis of FSP-1 positive cells was confirmed, since Langerhans cells within the epidermis are known to stain positive for mesenchymal markers. Immunostaining for FSP-1 (green) and Langerin (red) revealed that at least some of the FSP-1 positive cells were indeed from the Langerhans cell population (double positive cells shown with arrow). (BM = basement membrane, BV = blood vessels).</p

Canonical TGFβ signaling in SSc skin.

<p>(A) Representative images of double immunofluorescent staining performed to detect phospho-Smad2/3 (red) and K14 (green) in the epidermis of SSc patients and controls forearm skin sections (both n = 6, means of 5 high power views for each individual patient or control). DAPI (blue) was used to stain nuclei. Nuclear translocation of phospho-Smad2/3 was seen in SSc epidermal cells extending to suprabasal and granular layers. K14 expression was found to extend into suprabasal layers abnormally in SSc consistent with altered differentiation. (B) Also phospho-Smad2/3 nuclear translocation was seen in cells within the papillary dermis, increased in SSc sections (blue DAPI, red pSMAD2/3, double positive cells indicated with arrows). (C) When quantified the mean number of phospho-Smad2/3 positive cells was increased in SSc both in the epidermis (p<0.001) and in the adjacent papillary dermis (p<0.05) consistent with active TGFβ signaling. (D) qPCR of whole epidermal sheets obtained during suction blister formation revealed increased expression of SNAI1 transcription factor downstream of TGFβ. However SNAI2 was not increased. (ED = epidermis, PD = papillary dermis, RD = reticular dermis, ** = P<0.001, * = P<0.05).</p

TGFβ stimulated EMT in HaCat cells.

<p>(A) HaCat cells cultured for 72hrs with TGFβ1 4ng/ml became elongated, lost cytokeratin and induced FSP-1 expression consistent with transition to a mesenchymal phenotype. (B) Culture with TGFβ1 also led to induction of both <i>SNAI1</i> and <i>SNAI2</i> mRNA maximal with TGFβ1 2 ng/ml and consistent with fully evoked EMT.</p

Quantitative data underlying results in Fig 1A, 1D and 1J.

Quantitative data underlying results in Fig 1A, 1D and 1J.</p