A second-order slip model for arbitrary accomodation at the wall

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.We present a kinetic-theory derivation of second-order slip boundary conditions for a plane isothermal pressure driven gas owing through a microchannel. In the proposed approach, the distribution function is expanded in terms of orthogonal polynomials and the system of moment equations in the expansion coefficients is analytically solved. The velocity slip coefficients, as well as their Knudsen layer corrections, are obtained by evaluating the solution in the near continuum limit. In comparison with other methods, the present approach is accurate and easy to implement. The results are presented for the Bhatnagar-Gross-Krook-Welander (BGKW) kinetic model equation and Maxwell's boundary conditions, but can be extended to more general collision integral and different scattering kernels.Fondazione Cariplo within the framework of the project Surface interactions in micro/nano device

Coherent microscopy and optical coherence tomography for biomedical applications

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.In recent years many new methods of 3D optical imaging have been introduced that are applicable to the study of micro- and nano-scale flows. Coherent microscopy and optical coherence tomography join more established methods such as coherence scanning interferometry and confocal microscopy. These methods are very closely related and, using linear systems theory, can be compared in terms of their point spread and transfer functions. This paper introduces linear theory, demonstrates the main differences between the methods and discusses their use in micro- and nano-scale flow measurement. It is shown that coherent microscopy is currently the only method capable of single shot recording and consequently simultaneous whole-field flow measurement. Its use is limited to sparsely seeded flows however, such that individual particles can be identified. The other techniques provide increased 3D discrimination. Using a large numerical aperture, confocal microscopy and coherence scanning interferometry provide the most detailed 3D images making use the additional information available when the object is illuminated with plane waves propagating at different angles. In contrast optical coherence tomography uses the information that is available when the object is illuminated with different wavelengths. It is shown that the fundamental difference between these approaches is that the lateral and axial resolutions are decoupled in OCT making the technique easily scalable. This and the development of modern tunable laser sources, make OCT the method of choice for many biomedical applications

Multiscale modeling of physical and biological systems

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute

The hybrid grid implemented DSMC method used in 2D triangular micro cavity flows

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.In this study a new hybrid grid is implemented in a 2D DSMC solver to be used in 2D triangular micro cavity flows. Currently DSMC is the prominent method to analyze micro scale gas flows which are rarefied. Because of the computational cost, DSMC solvers are generally used in rarefied gas conditions in which continuum based solvers are useless. If the efficiency of DSMC solvers is improved, the application range of these solvers can be increased further where the continuum based solvers dominate. Indexing the particles according to their cells is one of the main steps in the DSMC method. Either the particles are traced cell-by-cell along their trajectories or coordinate transformation techniques are used in this step. The first option requires complex trigonometric operations and search algorithms which are computationally expensive. But it can be used in both structured and unstructured grids. Although the second option is computationally more efficient, it demands specially tailored structured grids which are more geometry dependent compared to the unstructured grids. Here it is shown that a novel hybrid grid structure can be used successfully in 2D DSMC solver to analyze triangular shaped lid-driven micro cavity flows. Hybrid grids used in this study are much less dependent of the geometry like unstructured grids. Additionally, hybrid grids like structured grids facilitate coordinate transformation techniques in order to increase the efficiency of the particle indexing step in the DSMC method

Thrust effectiveness of micronozzle

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.Thrust of the divergent part of axially symmetric micronozzle is under the study. It’s input to total thrust is considered by means of analysis of relative thrust determined as divergent part’s thrust related to nozzle’s thrust without divergent part when gas issuing into vacuum. An inviscid one-dimensional flow is used as start condition of analysis. For this case, it is shown from conservation laws that divergent part of infinite length has finite relative thrust depending only on sort of issuing gas. Analysis of the influence of shear stress on thrust of divergent part with the use of theory of laminar boundary layer shows that optimal nozzle wall angle at the exit increases and optimal length decreases with decreasing of nozzle’s dimension in comparison with initial inviscid case. This conclusion is approved by results of numerical simulation of flow inside nozzles with throat diameter 10 micrometers and various form of divergent part based on Navier – Stokes equations with both no-slip and slip wall conditions. Detailed analysis of flow shows advantage of micronozzles with wall form far from traditionally used in “large” thrusters.This study is partially supported by the Russian Foundation for Basic Research (Project 11-08-00422-а)

Reliability of large-eddy simulation

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute

Uncertainty quantification (UQ)

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.Uncertainty Quantification (UQ) is an emerging field in computational engineering that can provide certificates of fidelity in a simulation beyond the standard numerical error, and it includes uncertainty in boundary conditions, constitutive laws, materials properties and geometries. UQ is particularly impornat at microscales where geometric roughness and material properties cannot be readily quantified experimentally. Here we present a general framework for UQ based on the generalized polynomial chaos approach and various extensions that do not require modification of existing codes and are particularly effective in Microsystems with many uncertain parameters (e.g. high dimensionality)

Gas flow through a micro-orifice due to small pressure difference

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.Rarefied gas flow through a micro-orifice connecting two reservoirs at small pressure differences is considered in the whole range of rarefaction by the linearized BGK kinetic model equation. The problem is computationally challenging due to the five dimensional nature of the distribution function and techniques such as parallelization and numerical schemes of low memory requirements have been applied. Results include the distributions of density, velocity, temperature, as well as flow rates. The independence of flow rate in terms of the wall surface accommodation properties is confirmed.The European Community under the contract of Association EURATOM/Hellenic Republic

Iron oxide nanoparticles and derivatives for biomedical imaging and application in cancer diagnosis and siRNA therapy

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.Our studies have focused on the application of imaging-capable nanoparticulate agents for the delivery of small RNA-based tumor therapy. One example includes magnetic nanoparticles (MN), which have traditionally been utilized as contrast agents for magnetic resonance imaging. The probes typically consist of a dextran-coated superparamagnetic iron oxide core (for magnetic resonance imaging), labeled with Cy5.5 dye (for near-infrared in vivo optical imaging), and conjugated to synthetic small interfering RNA (siRNA) molecules targeting model or therapeutic genes. We have explored the potential of these nanoparticles as delivery modules for small interfering RNA to tumors. Furthermore, we have investigated the feasibility of combining the imaging and delivery capabilities of these nanoparticles for the tracking of siRNA bioavailability. The versatile functionalization potential of MN has allowed us to control properties of the agents, such as uptake mechanism and target organ distribution. The tumoral accumulation of MNsiRNA results in a remarkable level of target-gene down-regulation. Repeated treatment with MN-siBIRC5, targeting the tumor-specific anti-apoptotic gene, birc5, leads to the induction of apoptosis in the tumors and an overall reduction in tumor growth rate. More recently, we have synthesized a second generation of nanoparticles, which combine the capability for high-resolution magnetic resonance imaging with detection by ultrasensitive surface enhanced Raman scattering

Boundary condition, an old but not well solved problem, linked from nanometer to macroscale

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.A key issue of the flow and heat transfer in channels is to determine the boundary condition, which is affected by various parameters, such as the solid-fluid potential interactions, solid wall roughness, surface wettability etc. We summarize the progress that has been made in recent years. In the first part of this paper, we reviewed the three-atom-model, leading to an important criterion number governing the boundary conditions. The molecular dynamics (MD) simulations verified the effectiveness of the criterion number. The second part of this paper reports the multiscale simulation of the flow field in channels, adjoining the molecular dynamics (MD) simulation and the continuum fluid mechanics. Three types of boundary conditions (slip, non-slip and locking) were identified over the multiscale channel sizes. The slip lengths are found to be mainly dependent on the interfacial parameters with the fixed apparent shear rate. The channel size has little effects on the slip lengths if the size is above a critical value within a couple of tens of molecular diameters. The slip, non-slip and locking interfacial parameters yield positive, zero and negative slip lengths, respectively. The three types of boundary conditions existing in “microscale” still occur in “macroscale”. However, the weak dependence of the slip lengths on the channel size yields decreased slip velocities with increases in channel sizes for all three types of interfacial parameters.This study is supported by the National Natural Science Foundation of China (No. U1034004 and 50825603), and the Basic Research Program (973 program) with the contract number of 2011CB710703