ACTIVITY REPORT : Section 2. Sources of Atmospherics and Atmospheric Electricity

1984-03-25departmental bulletin pape

性犯罪規定の改正 : 要綱（骨子）案について

departmental bulletin pape

性犯罪規定の見直しに向けて : 不同意性交等罪の導入に対する疑問

departmental bulletin pape

Monitoring of intracellular 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in 1-beta-D-arabinofuranosylcytosine therapy at low and conventional doses.

1-beta-D-Arabinofuranosylcytosine (ara-C) is used empirically at a low, conventional, or high dose. Ara-C therapy may be optimal if it is directed by the clinical pharmacokinetics of the intracellular active metabolite of ara-C, 1-beta-D-arabinofuranosylcytosine 5'-triphosphate (ara-CTP). However, ara-CTP has seldom been monitored during low- and conventional-dose ara-C therapies because detection methods were insufficiently sensitive. Here, with the use of our newly established method (Cancer Res., 56, 1800 -- 1804 (1996)), ara-CTP was monitored in leukemic cells from acute myelogenous leukemia patients receiving low- or conventional-dose ara-C [subcutaneous ara-C administration (10 mg / m(2) ) (3 patients), continuous ara-C infusion (20 or 70 mg / m(2) / 24 h) (7 patients), 2-h ara-C infusion (70 mg / m(2) ) (4 patients), and 2-h infusion of N(4)-behenoyl-1-beta-D-arabinofuranosylcytosine, a deaminase-resistant ara-C derivative (70 mg / m(2) ) (6 patients)]. Ara-CTP could be determined at levels under 1 microM. There was a close correlation between the elimination half-life values of the plasma ara-C and the intracellular ara-CTP. The presence of ara-C in the plasma was important to maintain ara-CTP. The continuous ara-C and the 2-h N(4)-behenoyl-1-beta-D-arabinofuranosylcytosine infusions maintained ara-CTP and the plasma ara-C longer than the subcutaneous ara-C or the 2-h ara-C infusion. They also afforded relatively higher ara-CTP concentrations, and consequently produced ara-CTP more efficiently than the 2-h ara-C infusion. Different administration methods produced different quantities of ara-CTP even at the same dose.othe

松宮孝明教授 オーラルヒストリー

departmental bulletin pape

視覚的イメージスタイル質問紙作成の試み

本研究では，日常でのイメージ使用傾向を測定する視覚的イメージスタイル質問紙(VISQ)の作成を試みた。既存の質問紙から日常でのイメージ使用が関与しそうな項目を収集し，新たな項目を加え76個の質問項目を作成した。その中から幅広い調査対象者に調査可能だと思われる項目を吟味し，最終的に40項目の質問紙を作成した。大学生313名のデータを用いた因子分析からは，VISQ(24項目)の下位尺度として物体イメージの使用に関する“物体イメージ"尺度(12項目)と，空間イメージの使用に関する“空間イメージ"尺度(12項目)が得られた。信頼性係数や再検査の結果から，これらの下位尺度がイメージ質問紙に要求される信頼性の基準を満たした尺度であることが確認された。また視空間イメージ能力課題とV1SQ(24項目)の下位尺度の関係性からVISQの構成概念妥当性について検証したところ，物体イメージ尺度の得点がDPTやVVIQの得点と，空間イメージ尺度の得点がMRTやPFTの得点と特異的に関連する結果が得られた。これらの結果から，VISQが十分な概念妥当性を持つ質問紙であることが確認された。In this study, we attempted to develop a Visual Imagery Style Questionnaire (VISQ) for measuring individual differences in visual imagery preferences and experiences. Factor analysis was conducted on 40 items of the VISQ. The results of analysis yield 2 factors. The object imagery scale relates to the visual appearance of individual objects. The spatial imagery scale relates to the spatial location and spatial relation between parts of an object. A total of 24 items were selected to construct an object imagery scale (12 items) and a spatial imagery scale (12 items). These scales had an acceptable level of internal consistency and test-retest reliability. Subsequently, we examined the validity of the VISQ by evaluating the relationship between the two scales of the VISQ and visual imagery tasks. The object imagery scale was significantly correlated with object imagery tasks performance. The spatial imagery scale was significantly correlated spatial imagery tasks performance. These results confirmed the construct validity of VISQ.journal articl

Microscopic investigations of aluminum nitride thin films grown by low-temperature reactive sputtering

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