4 research outputs found
Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging
To explore the aetiology of pathological laughing, a 65-year-old woman with pathological laughing was examined by 3-T functional magnetic resonance imaging (fMRI) before and after treatment with drugs. Here, we report that the patient consistently showed exaggerated pontine activation during the performance of three tasks before treatment, whereas abnormal pontine activation was no longer found after successful treatment with the selective serotonin reuptake inhibitor, paroxetine. Our findings in this first fMRI study of pathological laughing suggest that serotonergic replacement decreases the aberrant activity in a circuit that involves the pons
The Hard Road to Reform : The Politics of Zimbabwe's Global Political Agreement
The defeat of ZANU-PF in the 2008 parliamentary election marked the end of one-party rule in Zimbabwe. The Global Political Agreement signed later that resulted in a Government of National Unity, and the former ruling party was, for the first time, faced with the reality of sharing power. The Hard Road to Reform presents a penetrating analysis of developments since the GNU was established, reviewing recent political history from a range of perspectives - political, economic, social and historical, and featuring the best work of Zimbabwe's young scholars. As Brian Raftopolos writes in his introduction: 'the book is an attempt to analyse and assess both the hopes and frustrations of the last four years and to confront the harsh challenges that lie ahead.
