Use of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats

AbstractBackgroundSevere destructive hepatic injuries can be induced by acetaminophen overdose and may lead to acute hepatic failure.ObjectiveTo investigate the ameliorative effects of Arctium lappa root extract on acetaminophen-induced hepatotoxicity.MethodsRats were divided into 4 groups: normal control group, Arctium lappa extract group, acetaminophen-injected group, and acetaminophen treated with Arctium lappa extract group.ResultsThe treatment with Arctium lappa extract reduced serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase in the acetaminophen group when compared with the control group. DNA fragments in the acetaminophen-injected group were also significantly increased (P < 0.05). The comet assay revealed increased detaching tail length and DNA concentration during the hepatic toxicity in the acetaminophen group. The malondialdehyde content was inhibited by Arctium lappa treatment (12.97±0.89 nmol/mg) when compared with the acetaminophen-treated-only group (12.97±0.89 nmol/mg). Histopathologic examination revealed that acetaminophen administration produced hepatic cell necrosis, infiltrate of lymphocytes, and vacuolation that were associated with the acetaminophen-treated animal group, but the degree of acetaminophen-induced hepatotoxicity was mediated by treatment with Arctium lappa extract.ConclusionsArctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats

掘削時の地盤の変形・土圧特性および近接構造物への影響

名古屋工業大学博士(工学)Doctor of Engineering主査：中井　照夫doctoral thesi

海外駐在員の妻の異文化受容と帰国文化適応-アメリカ滞在の場合-

Articledepartmental bulletin pape

食習慣の形成・食行動自立における指導と実践についての一考察

原著論文Original Papersdepartmental bulletin pape

A Study on the Enlightenment in Berlin. G.E.Lessing, M. Mendelssohn, Christian W. Dohm und das Judentum

text紀要論文 / Departmental Bulletin Paperdepartmental bulletin pape

Effects of Korean Red Pepper on Lipid Metabolism in the Rats

Effects of Korean red pepper on lipid metabolism were investigated using the rats. The red pepper was orally administrated as a part of diet. Daily intake of the red pepper decreased plasma triglyceride and deposit fat. The red pepper taken as a diet influences lipid metabolism and may have preventive effects on lifestyle-related disease.departmental bulletin pape

Fabrication of All-High-Tc Josephson Junction by Plasma Treatment

publisherAll-high-Tc Josephson junctions consisting of a YBCO/barrier/YBCO-layered structure using epitaxial YBCO films sputtered on MgO(100) have been successfully fabricated. The barrier layer was obtained by Ar+O2 plasma treatment of the surface of the base electrodes. These junctions show superconductor/normal-metal/superconductor(SNS) -like current-voltage characteristics. Constant-voltage current steps observed in response to 10GHz microwave radiation show that ac-Josephson effects occur in these junctions.departmental bulletin pape

The relationship of the gender role of male caregivers to their care related psychological factors

journal articl

A case of mucoepidermoid carcinoma arising in mature cystic teratoma

卵巣粘表皮癌は卵巣悪性腫瘍の中で極めてまれな組織型に分類される。今回、我々は成熟嚢胞性奇形種より発生した卵巣粘表皮癌の症例を経験したので報告する。症例は、69歳、女性、両側の成熟嚢胞性奇形腫を認めたが、SCC高値とCT、MRI にて左側の腫瘍内に造影される充実性部分を認めたこと、小腸に浸潤を疑う所見を認めたこと、から悪性転化を疑い、手術を施行した。開腹時、両側卵巣腫瘍を認め、左卵巣腫瘍はS状結腸と強固に癒着していた。卵巣腫瘍充実性部分の迅速病理にて低分化癌と診断し、単純子宮全摘出術、両側付属器摘出術、S状結腸合併切除、骨盤リンパ節郭清術、大網切除術を施行した。病理組織学的には、左卵巣腫瘍の嚢胞壁肥厚部に皮膚付属器、脂肪織、軟骨組織、リンパ球集簇、卵巣間質を認め、充実成分に低分化な浸潤性扁平上皮癌を認めた。充実成分には、粘表皮癌に特徴的な、豊富な胞体粘液（PASおよびAlcian blue 染色陽性）を有する異型細胞が胞巣状～不完全な腺管状を呈する領域があり、成熟嚢胞性奇形腫より発生した卵巣粘表皮癌IIb期（pT2bN0M0）と診断した。術後補助化学療法としてDC（ドセタキセル、カルボプラチン）療法を施行し、術後1年8ヶ月現在、再発を認めない。journal articl

兵庫県立芦屋高等学校改善プラン ： 学校経営ビジョンの明確化と校内組織の機能強化を目指して

兵庫教育大学教職修士（専門職）application/pdfabstract特定の課題についての学修の成果内容要旨thesi