バイオ産業における素材技術の応用に関する研究

名古屋工業大学博士(工学)Doctor of Engineering主査：小竹　暢隆doctoral thesi

モスフードサービスの国際化・グローバル化について今後の展望と将来ビジョン―モスフードサービス，櫻田厚会長へのインタビューを中心として―

Article研究課題：「台湾進出日系合弁企業における現地経営資源の活用と経営課題の実態調査」 Research：A Fact Finding Survey of Management Problems and Practical Use of the Local Managerial Resources of Japanese Joint Venture Companies in Taiwandepartmental bulletin pape

日本における中国研究 ―展開と課題―

［特集］第2回エズラ・ヴォーゲル記念フォーラム「アジア研究の過去・現在・未来（そのII）」othe

Atypical ductal hyperplasia on vacuum-assisted breast biopsy: a scoring system to predict the risk of upgrade to malignancy

Rationale and objectives: Our multicentric study analysed clinical, radiologic and pathologic features in patients with atypical ductal hyperplasia (ADH) diagnosed with vacuum-assisted biopsy (VAB), to identify factors associated with the risk of upgrade, to develop a scoring system to support decision making. Materials and methods: Patients with ADH on VAB under stereotactic/tomosynthesis guidance (2012–2022) were eligible. Inclusion criteria were availability of surgical histopathological examination of the entire lesion or radiologic follow-up (FUP) ≥ 24 months. VAB results were compared with surgical pathological results or with imaging FUP evolution to assess upgrade. A backward stepwise linear regression was used to identify predictors of upgrade. The discriminatory power of the model was calculated through the area under the receiver operating curve (ROC–AUC); the Hosmer–Lemeshow test was used to assess model calibration. The points system was developed based on the selected risk factors, and the probability of upgrade associated with each point total was determined. Results: 112 ADH lesions were included: 91 (91/112, 81.3%) underwent surgical excision with 20 diagnosis of malignancy, while 21 (21/112, 18.7%) underwent imaging FUP with one interval change (mean FUP time 48 months). Overall upgrade rate was 18.7% (21/112). Age, menopausal status, concurrent breast cancer, BIRADS classification and number of foci of ADH were identified as risk factors for upgrade. Our model showed an AUC = 0.85 (95% CI 0.76–0.94). The points system showed that the risk of upgrade is < 2% when the total score is ≤ 1. Conclusion: Our scoring system seemed a promising easy-to-use decision support tool for management of ADH, decreasing unnecessary surgeries, reducing patients’ overtreatment and healthcare costs

Report of the Public Online Educational Program for Migrants about COVID-19

departmental bulletin pape

Magnetic seed versus skin tattoo localization of non-palpable breast lesions: a single institution cohort study

Objective: The objective of this retrospective study was to investigate the accuracy and feasibility of magnetic seed compared to skin tattoo in preoperative localization of impalpable breast lesions in terms of accuracy of placement, re-excision and positive margins rates, and breast/surgical specimen volume ratio. Methods: We retrospectively analyzed 77 patients who underwent breast conservative surgery in our center from November 2020 to November 2021, with previous localization with skin tattoo or magnetic seed. Results: Thirty-seven magnetic seeds were placed in 36 patients (48.6%) and 40 skin tattoos were performed in the remaining cases (51.4%). The seeds were placed correctly at the two-view mammogram acquired after the insertion in 97.6% (36/37) of cases. With both methods, 100% of the index lesions were completely removed and found in the surgical specimen. The reported re-excision rate was 0% for both groups. A significant difference was observed in the volume of breast parenchyma removed between the two groups, inferior in the seed group (p = 0.046), especially in case of voluminous breasts (p = 0.003) and small lesions (dimension < 8 mm, p = 0.019). Conclusions: Magnetic seed is a non-radioactive localization technique, feasible to place, recommended in case of non-palpable breast lesions, saving the breast parenchyma removed compared with skin tattoo, without reducing the accuracy. Clinical relevance statement: Our findings contribute to the current evidence on preoperative localization techniques for non-palpable breast lesions, highlighting the efficacy of magnetic seed localization for deep and small lesions. Key points: • Magnetic seed is a non-radioactive technique for the preoperative localization of non-palpable breast lesions studied in comparison with skin tattoo. • Magnetic seed is feasible to place in terms of post-placement migration and distance from the target lesion. • Magnetic seed is recommended in case of non-palpable breast lesions, saving the breast parenchyma removed without reducing the accuracy

Image-guided localization techniques for surgical excision of non-palpable breast lesions: An overview of current literature and our experience with preoperative skin tattoo

Breast conserving surgery has become the standard of care and is more commonly performed than mastectomy for early stage breast cancer, with recent studies showing equivalent survival and lower morbidity. Accurate preoperative lesion localization is mandatory to obtain adequate oncological and cosmetic results. Image guidance assures the precision requested for this purpose. This review provides a summary of all techniques currently available, ranging from the classic wire positioning to the newer magnetic seed localization. We describe the procedures and equipment necessary for each method, outlining the advantages and disadvantages, with a focus on the cost-effective preoperative skin tattoo technique performed at our centre. Breast surgeons and radiologists have to consider ongoing technological developments in order to assess the best localization method for each individual patient and clinical setting

Conventional CT versus Dedicated CT Angiography in DIEP Flap Planning: A Feasibility Study

The deep inferior epigastric perforator (DIEP) flap is used with increasing frequency in post-mastectomy breast reconstruction. Preoperative mapping with CT angiography (CTa) is crucial in reducing surgical complications and optimizing surgical techniques. Our study\u2019s goal was to investigate the accuracy of conventional CT (cCT), performed during disease staging, compared to CTa in preoperative DIEP flap planning. In this retrospective, single-center study, we enrolled patients scheduled for mastectomy and DIEP flap breast reconstruction, subjected to cCT within 24 months after CTa. We included 35 patients in the study. cCT accuracy was 95% (CI 0.80\u20130.98) in assessing the three largest perforators, 100% (CI 0.89\u2013100) in assessing the dominant perforator, 93% (CI 0.71\u20130.94) in assessing the perforator intramuscular course, and 90.6% (CI 0.79\u20130.98) in assessing superficial venous communications. Superficial inferior epigastric artery (SIEA) caliber was recognized in 90% of cases (CI 0.84\u20130.99), with an excellent assessment of superficial inferior epigastric vein (SIEV) integrity (96% of cases, CI 0.84\u20130.99), and a lower accuracy in the evaluation of deep inferior epigastric artery (DIEA) branching type (85% of cases, CI 0.69\u20130.93). The mean X-ray dose spared would have been 788 \ub1 255 mGy/cm. Our study shows that cCT is as accurate as CTa in DIEP flap surgery planning

Measurement of the Termic Effect of Food Using a Non-Invacive Zero Heat Flow Thermometry System.

食事摂取後の各栄養素の消化・吸収，栄養素の蓄積による体温上昇効果を総称して食事性熱産生効果Thermic Effect of Food（TEF）という。栄養学的介入の際にTEFを測定・分析することは重要であるが，侵襲度が高く，あるいは高価な測定器具が必要であった。本研究では，非侵襲的な熱流補償式体温測定原理を用いた深部体温測定システムを用いてTEFの測定を試みた。健常者6名それぞれに高炭水化物食と高たんぱく質食を摂取させた後の酸素消費量から算出したエネルギー消費量と深部体温を食後150分まで経時的に測定し，それぞれの測定値からTEF（TEFcal，TEFtbc）を算出した。その結果、TEFcalの曲線下面積は高たんぱく質食群で高値を示した（p＜0.05）。深部体温は高たんぱく質食群において摂取後10分と150分の間で有意に上昇した。TEFcbtの曲線下面積は，TEFcal同様，高たんぱく質食群のほうが高値傾向にあり，これらのことから，熱流補償式体温測定原理を用いた深部体温測定システムを用いてTEF測定・評価を行える可能性が示された。departmental bulletin pape

The assisi think tank meeting breast large database for standardized data collection in breast cancer\u2014attm.Blade

Background: During the 2016 Assisi Think Tank Meeting (ATTM) on breast cancer, the panel of experts proposed developing a validated system, based on rapid learning health care (RLHC) principles, to standardize inter-center data collection and promote personalized treatments for breast cancer. Material and Methods: The seven-step Breast LArge DatabasE (BLADE) project included data collection, analysis, application, and evaluation on a data-sharing platform. The multidisciplinary team developed a consensus-based ontology of validated variables with over 80% agreement. This English-language ontology constituted a breast cancer library with seven knowledge domains: baseline, primary systemic therapy, surgery, adjuvant systemic therapies, radiation therapy, followup, and toxicity. The library was uploaded to the BLADE domain. The safety of data encryption and preservation was tested according to General Data Protection Regulation (GDPR) guidelines on data from 15 clinical charts. The system was validated on 64 patients who had undergone post-mastectomy radiation therapy. In October 2018, the BLADE system was approved by the Ethical Committee of Fondazione Policlinico Gemelli IRCCS, Rome, Italy (Protocol No. 0043996/18). Results: From June 2016 to July 2019, the multidisciplinary team completed the work plan. An ontology of 218 validated variables was uploaded to the BLADE domain. The GDPR safety test confirmed encryption and data preservation (on 5000 random cases). All validation benchmarks were met. Conclusion: BLADE is a support system for follow-up and assessment of breast cancer care. To successfully develop and validate it as the first standardized data collection system, multidisciplinary collaboration was crucial in selecting its ontology and knowledge domains. BLADE is suitable for multi-center uploading of retrospective and prospective clinical data, as it ensures anonymity and data privacy