THEORETICAL ANALYSES AND EXPERIMENTAL VALIDATION OF DYNAMIC RESPONSES OF FINE-WIRE SENSORS TO FLUCTUATING VELOCITY AND TEMPERATURE OF FLUID FLOWS

名古屋工業大学博士(工学)Doctor of Engineering主査：田川　正人doctoral thesi

聴覚障害者の非公式なコミュニケーションへの対処戦略 : 当事者のライフストーリーの分析から

application/pdf社會問題研究. 2009, 58, p.103-116departmental bulletin pape

Improvement in the Technique of the Volumetric Water-Vapour Adsorption Measurement (Part 2)

publisherIn the application of the method proposed in the previous papers to real water-vapour adsorption measurements it has been found to be confronted with a few difficulties as follows : 1) It takes long time to determine a full absorption isotherm. 2) Several samplings are indispensable to obtain a full adsorption isotherm so that the measurement will be attended with sampling errors. 3) The changes in the surface properties of the sample may be involved in consequence of the repetition of adsorption/desorption cycles. So in this paper, the authors give the new method based on the conventional volumetric method, which has the blank test as an improvement to determine the full adsorption isotherm of water-vapour on the used grease and the used oil. By means of this method the precise and accurate adsorption isotherm of water-vapour on the zinc oxide powdery sample is obtained without the above-mentioned difficulties.departmental bulletin pape

Association between uric acid levels and alcohol consumption and beverage type: A cross sectional study using large health checkup data in Japan

聖路加国際大学修士（公衆衛生学）2021doctoral thesi

A case of strumal carcinoid of ovary detected incidentally at total abdominal hysterectomy

卵巣カルチノイドは全卵巣腫瘍の 0.1%以下を占める稀な境界悪性腫瘍である。今回我々は、子宮全摘と片側付属器摘出術後に判明した卵巣原発甲状腺腫性カルチノイドの 1 例を経験したので報告する。 症例は46歳、２経妊１経産。子宮癌検診で classⅢb のため当院紹介初診。子宮頸部組織診にて CIS を認め、開腹手術を施行した。開腹所見では右卵巣は 3-4cm大で、正常卵巣部分の他に、腫瘍を疑う弾性硬の部分を認めたため、単純子宮全摘術と右付属器摘出術を施行した。病理組織所見で、右卵巣腫瘍には甲状腺濾胞部分とカルチノイド部分を認め、免疫組織染色では、Thyroid Transcription Factor (TTF-1), Thyroglobulin, Synaptophysin, Chromogranin A が陽性であり、甲状腺腫性カルチノイドと診断した。また、peptide YY も陽性だった。最終診断では卵巣原発甲状腺腫性カルチノイドⅠa期と診断した。journal articl

Incidence on grape phenolic composition of foliar treatments with methyl jasmonate and methyl jasmonate supported on nanoparticle

Tools to address the mismatch, due to climate change, between technological andphenolic maturities of grapes are needed. Foliar application of elicitors in the vineyard could bean interesting alternative. This work studies the influence of the treatment with methyl jasmonate(MeJ) in free form and, as a novelty, in the form of MeJ-doped nanoparticles (ACP-MeJ) onTempranillo grapes phenolic composition over two vintages (2019 and 2020). The resultsshowed that, regardless of vintage, both treatments (MeJ and ACP-MeJ) increased the grapetotal phenols content. In 2019, most of the anthocyanins, and to a lesser extent the flavanols,increased their content with the MeJ application, and the concentration of severalhydroxycinnamic acids enhanced in the grapes treated with ACP-MeJ, with dose 10 times lowerthan those of the MeJ free. In 2020, anthocyanins contents were not affected by the foliarapplications, but total flavanols, flavonols, hydroxybenzoic acid, and stilbenes concentrationincreased after ACP-MeJ treatment. Therefore, the applications of this elicitor in the vineyardcould be a good tool to achieve an increase of grape phenolic compounds, improving not onlythe organoleptic properties, color stability, and healthy characteristics, for which they areresponsible in grapes, so, improving grape quality, but also allowing bringing closer the grapetechnological and phenolic maturities. Besides, the application of the elicitor in nano form (ACPMeJ), allows reducing both, the economical and the environmental impact of this technique inthe vineyard. Nevertheless, as the results were not equivalent between the two vintages understudy, it would be desirable to carry out more trials to determine the effect of these foliarapplications under different edaphoclimatic and varietal conditions in order to obtain a moresolid response to their influence on the grape phenolic composition

Methyl jasmonate and/or urea in conventional and nanoparticle form: Effect on phenolic compounds in Tempranillo grapes

Nowadays, nanotechnology has gained interest in viticulture as a promising tool for sustainable agriculture. Nanoparticles(NPs) are used as nanotransporters of active compounds (nutrient, elicitor, etc.), allowing their slow and prolonged release,which is a great advantage for their use in agriculture. On the other hand, climatic variations due to global warming are affecting crops, especially grapevines, and are causingimbalances in the phenolic and technological maturity of grapes. To mitigate these effects, strategies such as the use ofelicitors, compounds that induce the synthesis of secondary metabolites and improve plant defence mechanisms, are beinginvestigated. One of the most investigated in vines is methyl jasmonate (MeJ), because it improves the phenolic, aromaticand nitrogen composition of grapes. MeJ has also been used supported on amorphous calcium phosphate (ACP) NPs withgood results.In parallel to this, the use of urea (Ur) as a source of nitrogen (N) is essential for healthy vine development, the production ofquality grapes and proper fermentation during winemaking. The high solubility of Ur in water makes it easily assimilated byplants. Despite its importance, research on the use of Ur in viticulture and its effect on the phenolic composition of grapes islimited. However, Ur has been applied in conventional and doped form in ACP, achieving a significant reduction of applied Nwithout altering grape quality.Therefore, the aim of this study was to determine the effect of foliar applications of MeJ and Ur in free form and supportedon nanoparticles, as well as their combinations, on the phenolic composition of Tempranillo grapes. In addition, if there isany synergistic effect between both substances was sought and if it is possible to reduce their concentration with the nanoformat to improve the phenolic compounds of the grape.This study analyzed the effects of different foliar treatments on the concentration of phenolic compounds in Tempranillograpes. The treatments applied were: water (Control), (MeJ), (Ur), combination (MeJ+Ur); as well as amorphous calciumphosphate (ACP) NPs doped with MeJ (ACP-MeJ), Ur (ACP-Ur) and a combination (ACP-MeJ+Ur). Several families of phenoliccompounds were analyzed by high performance liquid chromatography: anthocyanins, flavonols, flavanols, stilbenes,hydroxybenzoic (HBA) and hydroxycinnamic acids (HCA).The treatments did not affect must quality or gallic acid concentration. MeJ treatment significantly increased the levels ofsome anthocyanins, and most flavonols and stilbenes, the latter being almost twice as high as in the control treatment, whilemost HCAs decreased. ACP-MeJ reduced flavanols and HCAs, and had little effect on other polyphenols. Ur treatment onlyaffected some polyphenols, while ACP-Ur reduced flavanols, HCAs and stilbenes. Grapes treated with MeJ+Ur also increasedflavonols, but decreased most HCAs, and was the only treatment that increased malic acid; while ACP-MeJ+Ur reduced mostflavanols and HCAs.The combination of MeJ and Ur had a synergistic effect on increasing flavonols, but the use of NPs as carriers of MeJ and/orUr had no effect on increasing phenolic compounds and reduced the concentration of flavanols and HCAs in grapes. Higherdose trials and further study of the effect on other compounds would be needed to elucidate the true extent of thetreatments on Tempranillo grapesEn los últimos años, la nanotecnología ha ganado interés en viticultura como una herramienta prometedora para unaagricultura sostenible. Las nanopartículas (NP) son utilizadas como nanotransportadores de compuestos activos (nutrientes,elicitores, etc.), permitiendo su liberación lenta y prolongada, lo que es una gran ventaja para su uso en la agricultura.Por otro lado, las variaciones climáticas debido al calentamiento global están afectando a los cultivos, especialmente a la vid,y están causando desajustes en la madurez fenólica y tecnológica de las uvas. Para contrarrestar estos efectos, se estáninvestigando estrategias como el uso de elicitores, compuestos que inducen la síntesis de metabolitos secundarios y mejoranlos mecanismos de defensa de las plantas. Uno de los más investigados en viña es el metil-jasmonato (MeJ), porque mejorala composición fenólica, aromática y nitrogenada de las uvas. MeJ también se ha usado soportado en NP de fosfato de calcioamorfo (ACP) con buenos resultados.Paralelo a esto, el uso de urea (Ur) como fuente de nitrógeno (N) es fundamental para el desarrollo saludable de la vid, laproducción de uvas de calidad y la correcta fermentación durante la elaboración del vino. La alta solubilidad de la Ur en aguala hace fácilmente asimilable por las plantas. A pesar de su importancia, la investigación sobre el uso de Ur en viticultura y suefecto en la composición fenólica de las uvas es limitada. Sin embargo, se ha aplicado Ur en forma convencional y dopada enACP, logrando una significativa reducción del N aplicado sin alterar la calidad de las uvas.Por ello, el objetivo de este estudio fue conocer el efecto de las aplicaciones foliares de MeJ y Ur en forma libre y soportadosen nanopartículas, así como sus combinaciones, sobre la composición fenólica de uvas de Tempranillo. Además, se buscódeterminar si existe algún efecto sinérgico entre ambas sustancias y si es posible reducir su concentración con el formatonano para mejorar los compuestos fenólicos de la uva.Este estudio analizó los efectos de diferentes tratamientos foliares en uvas Tempranillo sobre la concentración decompuestos fenólicos. Los tratamientos aplicados fueron: agua (Control), (MeJ), (Ur), combinación (MeJ+Ur); así como NP de fosfato calcio amorfo (ACP) dopadas con MeJ (ACP-MeJ), Ur (ACP-Ur) y una combinación (ACP-MeJ+Ur). Se analizaron variasfamilias de compuestos fenólicos mediante cromatografía líquida de alta resolución: antocianos, flavonoles, flavanoles,estilbenos, ácidos hidroxibenzoicos (AHB) e hidroxicinámicos (AHC).Los tratamientos no afectaron a la calidad del mosto ni a la concentración de ácido gálico. El tratamiento con MeJ aumentósignificativamente los niveles de algunos antocianos, y la mayoría de flavonoles y estilbenos, siendo estos últimos casi eldoble que en el tratamiento Control, mientras que la mayoría de AHCs disminuyeron. ACP-MeJ redujo flavanoles y AHCs, ytuvo poco efecto en otros polifenoles. El tratamiento con Ur solo afectó a algunos polifenoles, mientras que ACP-Ur redujolos flavanoles, AHCs y estilbenos. Las uvas tratadas con MeJ+Ur también aumentaron los flavonoles, pero disminuyeron lamayoría de AHCs, y fue el único tratamiento que incrementó el ácido málico; mientras que ACP-MeJ+Ur redujo la mayoría deflavanoles y AHCs.La combinación de MeJ y Ur tuvo un efecto sinérgico en el aumento de flavonoles, pero el uso de NP como portadores deMeJ y/o Ur no tuvo ningún efecto en el incremento de compuestos fenólicos y redujo la concentración de flavanoles y AHCsen las uvas. Se necesitarían ensayos con dosis más altas y un estudio más amplio del efecto sobre otros compuestos paradilucidar el verdadero alcance de los tratamientos sobre las uvas de Tempranillo.Negli ultimi anni, la nanotecnologie ha guadagnato interesse in viticoltura come strumento promettente per un'agricolturasostenibile. Le nanoparticelle (NPs) sono utilizzate come nanotrasportatori per composti attivi (nutrienti, elicitori, ecc.),consentendo un rilascio lento e prolungato, il che rappresenta un grande vantaggio per il loro uso in agricoltura.D'altra parte, le variazioni climatiche dovute al riscaldamento globale stanno influenzando le colture, in particolare la vite, estanno causando squilibri nella maturità fenolica e tecnologica delle uve. Per contrastare questi effetti, si stanno studiandostrategie come l'utilizzo di elicitori, composti che inducono la sintesi di metaboliti secondari e migliorano i meccanismi didifesa delle piante. Uno dei più studiati in vigna è il metil jasmonato (MeJ), perché migliora la composizione fenolica,aromatica e azotata dell'uva. Il MeJ è stato utilizzato anche supportato da NPs di fosfato di calcio amorfo (ACP) con buonirisultati.Parallelamente, l'uso dell'urea (Ur) come fonte di azoto è essenziale per un sano sviluppo della vite, la produzione di uve diqualità e la corretta fermentazione durante la vinificazione. L'elevata solubilità dell'Ur in acqua lo rende facilmenteassimilabile dalle piante. Nonostante, la sua importanza, la ricerca sull'uso dell'Ur in viticoltura e sul suo effetto sullacomposizione fenolica dell´uva è limitate. Tuttavia, l'Ur è stata applicata in forma convenzionale e drogata negli ACP,ottenendo una significativa riduzione dell'azoto applicato senza alterare la qualità dell'uva.Pertanto, lo scopo di questo studio è stato quello di determinare l'effetto delle applicazioni fogliari di MeJ e Ur in forma liberae supportata da nanoparticelle, nonché delle loro combinazioni, sulla composizione fenolica delle uve Tempranillo. Inoltre, siè cercato di determinare se esiste un effetto sinergico tra le due sostanze e se è possibile ridurne la loro concentrazione conil formato nano per migliorare i composti fenolici dell'uva.Questo studio ha analizzato gli effetti di diversi trattamenti fogliari nell´uva Tempranillo sulla concentrazione di compostifenolici. I trattamenti applicati sono stati: acqua (Controllo), (MeJ), (Ur), combinazione (MeJ+Ur); così come NPs di fosfato dicalcio amorfo (ACP) drogate con MeJ (ACP-MeJ), Ur (ACP-Ur) e una combinazione (ACP-MeJ+Ur). Diverse famiglie di compostifenolici sono state analizzate mediante cromatografia liquida ad alta prestazione: antociani, flavonoli, flavanoli, stilbeni, acidiidrossibenzoici (HBA) e idrossicinnamici (HCA).I trattamenti non hanno influenzato sulla qualità del mosto o sulla concentrazione di acido gallico. Il trattamento con MeJ haaumentato significativamente i livelli di alcuni antociani e della maggior parte dei flavonoli e degli stilbeni, quest´ultimi quasidoppio rispetto al trattamento di Controllo, mentre la maggior parte degli HBA è diminuita. L'ACP-MeJ ha ridotto i flavanoli egli HCA, mentre ha avuto scarso effetto su altri polifenoli. Il trattamento Ur ha influito solo su alcuni polifenoli, mentre ACPUr ha ridotto i flavanoli, gli HCA e gli stilbeni. Anche l'uva trattata con MeJ+Ur ha aumentato i flavonoli, ma ha diminuito lamaggior parte degli HCA ed è stato l'unico trattamento ad aumentare l'acido malico; mentre ACP-MeJ+Ur ha ridotto lamaggior parte dei flavanoli e degli HCA.La combinazione di MeJ e Ur ha avuto un effetto sinergico sull'aumento dei flavonoli, ma l'uso di NPs come vettori di MeJ e/oUr non ha avuto alcun effetto sull'aumento dei composti fenolici e ha ridotto la concentrazione di flavanoli e HCA nell'uva.Per chiarire la reale portata dei trattamenti sull'uva Tempranillo sarebbero necessarie prove con dosi più elevate e ulterioristudi dell'effetto su altri composti

Surgical repair for primary tricuspid regurgitation related to trauma

We report a case of a 45-year-old man presenting with tachycardia and palpitation. Echocardiography indicated severe tricuspid regurgitation. We suspected traumatic tricuspid damage due to high energy trauma in a motor vehicle accident 17 years earlier. He underwent a sternotomy, and his tricuspid valve was repaired with chordal reconstruction, indentation closure, and ring annuloplasty. The postoperative period was uneventful, and he was discharged 10 days after the operation. This report highlights the value of echocardiography for diagnosis of primary tricuspid regurgitation related to trauma, and the importance of early diagnosis to allow surgical intervention before irreversible damage occurs. Learning objective: Traumatic tricuspid regurgitation is a rare cardiovascular complication of blunt chest trauma. The mechanism of the tricuspid valve injury is thought to be secondary to sudden impact causing an anteroposterior compression of the right ventricle by the sternum in end-diastole. This injury is often incidentally identified or can be missed until the patient experiences symptoms of right heart failure resulting from severe tricuspid regurgitation.journal articl