75 research outputs found
An anomalous hydration/dehydration sequence for the mild generation of a nitrile oxide
Get PDFA nitrile oxide containing a carbamoyl group is readily generated upon the treatment of 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with water under mild reaction conditions, even in the absence of special reagents. The obtained nitrile oxide undergoes cycloaddition with dipolarophiles, alkynes and alkenes, to afford the corresponding isoxazol(in)es, which are useful intermediates in the synthesis of polyfunctionalized compounds. A plausible mechanism underlying the formation of the nitrile oxide is proposed, which involves an anomalous hydration/dehydration sequence. DFT calculations were also performed to support this mechanism
The role of platelets in the mechanism of pathogenesis of bronchial asthma
Get PDF研究成果の概要（和文）：気管支喘息における血小板由来成長因子（PDGF）による気管支平滑筋細胞増殖のメカニズムの解明を目指し，Neurokinin-1(NK1)受容体を高発現させたヒト気管支平滑筋由来の初代培養細胞に，G蛋白βγシグナリング阻害薬（Gallein）で前処理を行ったところ，PDGFによる細胞増殖が抑制され，その抑制効果は以前報告したNK1受容体作動薬のSM-SubPよりも強かった．LAM 細胞を用いた検討では，その異常な細胞増殖のメカニズムの一つとしてPTENを介する細胞増殖抑制の制御異常の可能性を示す結果を得た．研究成果の概要（英文）：To elucidate the mechanism of platelet-derived growth factor (PDGF)-induced airway smooth muscle cells proliferation in bronchial asthma, human airway smooth muscle cells stably transfected with the Neurokinin-1 receptor were pretreated with G protein βγ signaling inhibitor (Gallein). PDGF-induced cell proliferation was inhibited by Gallein, and the inhibitory effect was stronger than that of SM-SubP, an NK1 receptor agonist we reported previously. In addition, our experiment of LAM cells showed that the dysregulation of PTEN-mediated inhibition of cell proliferation may be one of the mechanisms of abnormal cell proliferation in LAM cells.・2021(令和3)年度 科学研究費補助金 基盤研究(C) 研究成果報告書・研究期間 (年度)：2017-04-01 – 2022-03-31・研究分野：炎症免疫・研究成果の学術的意義や社会的意義 : 気管支喘息は気道過敏性の亢進，気道狭窄を特徴とする慢性閉塞性の肺疾患である．G蛋白βγシグナリング阻害薬（Gallein）はPI3KおよびRac1を介するシグナリングを抑制する．本研究により，G蛋白βγサブユニットが，NK1受容体を介するPDGFの気管支平滑筋細胞増殖に関与することが示唆された．気管支平滑筋の細胞増殖に関わる分子シグナル伝達経路は，喘息由来の気管支狭窄に対して潜在的治療標的になる可能性が考えられ，この分野の新しい治療法が確立できれば，学術的および社会的にも意義の高いものになる．研究課題/領域番号 : 17K11976research repor
Investigation of secondary metabolism in actinomycetes of the genera Catellatospora and Allokutzneria（カテラトスポラ属とアロクツネリア属放線菌における二次 代謝能の解明）
Get PDF富山県立大学博士（工学）令和５年度thesi
Subaru Imaging of Asymmetric Features in a Transitional Disk in Upper Scorpius
Get PDFWe report high-resolution (0.07 arcsec) near-infrared polarized intensity
images of the circumstellar disk around the star 2MASS J16042165-2130284
obtained with HiCIAO mounted on the Subaru 8.2 m telescope. We present our
-band data, which clearly exhibits a resolved, face-on disk with a large
inner hole for the first time at infrared wavelengths. We detect the
centrosymmetric polarization pattern in the circumstellar material as has been
observed in other disks. Elliptical fitting gives the semimajor axis, semiminor
axis, and position angle (P.A.) of the disk as 63 AU, 62 AU, and -14
, respectively. The disk is asymmetric, with one dip located at P.A.s
of . Our observed disk size agrees well with a previous study
of dust and CO emission at submillimeter wavelength with Submillimeter Array.
Hence, the near-infrared light is interpreted as scattered light reflected from
the inner edge of the disk. Our observations also detect an elongated arc (50
AU) extending over the disk inner hole. It emanates at the inner edge of the
western side of the disk, extending inward first, then curving to the
northeast. We discuss the possibility that the inner hole, the dip, and the arc
that we have observed may be related to the existence of unseen bodies within
the disk.Comment: 21 pages, 3 figures, published 2012 November 7 by ApJL, typo
correcte
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