「白滝型」細石刃核について

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乳児と幼児の「遊び歌」に関する考察 ： 新曲作成の試み

兵庫教育大学修士thesi

磨製石斧の土器収納

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「神子柴論争」の行方

Articledepartmental bulletin pape

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その他 / Othersothe

The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing

Although the only effective drug against primary hepatocarcinoma, the multikinase inhibitor Sorafenib (SFB) usually fails to eradicate liver cancer. Since SFB targets mitochondria, cell metabolic reprogramming may underlie intrinsic tumor resistance. To characterize cancer cell metabolic response to SFB, we measured oxygen consumption, generation of reactive oxygen species (ROS) and ATP content in rat LCSC (Liver Cancer Stem Cells) -2 cells exposed to the drug. Genome wide analysis of gene expression was performed by Affymetrix technology. SFB cytotoxicity was evaluated by multiple assays in the presence or absence of metabolic inhibitors, or in cells genetically depleted of mitochondria. We found that low concentrations (2.5-5\u2005\u3bcM) of SFB had a relatively modest effect on LCSC-2 or 293\u2005T cell growth, but damaged mitochondria and increased intracellular ROS. Gene expression profiling of SFB-treated cells was consistent with a shift toward aerobic glycolysis and, accordingly, SFB cytotoxicity was dramatically increased by glucose withdrawal or the glycolytic inhibitor 2-DG. Under metabolic stress, activation of the AMP dependent Protein Kinase (AMPK), but not ROS blockade, protected cells from death. We conclude that mitochondrial damage and ROS drive cell killing by SFB, while glycolytic cell reprogramming may represent a resistance strategy potentially targetable by combination therapies

A case of retroperitoneal paraganglioma diagnosed by superimposed preeclampsia and cardiac arrest in postpartum three months

高血圧症において二次性高血圧が原因となる割合は１０％であり、高血圧合併妊娠において二次性高血圧が占める割合はさらに低い。今回我々は、加重型妊娠高血圧腎症の産褥３ヶ月に心停止を来たし後腹膜発生の傍神経節腫と診断された1例を経験したので、若干の文献的考察を加えて報告する。 症例は３１歳、１経妊０経産（人工妊娠中絶１回）、既往歴はない。妊娠初期より血圧高値のため高血圧合併妊娠の診断にて管理していたが、加重型妊娠高血圧腎症の診断となり、妊娠３４週で緊急帝王切開を施行した。産褥３ヶ月、内科で高血圧の精査中に心停止を来し、後腹膜発生の傍神経節腫と診断された。高血圧合併妊娠においては二次性高血圧も念頭に置いた精査、管理が重要であり、原因の特定、治療により母児の生命予後を改善することができる。journal articl

Dalitz analysis of three-body charmless B0-->K0pi+pi- decay

journal articl

John R. Hanson, Trade in Transition: Exports from the Third World, 1840-1900 Academic Press ; New York 1980, pp. xii+197.

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