65 research outputs found
Application of Remote Sensing and GIS Techniques for Analysis of Lake Water Fluctuations and the Potential Impact of Human Activities: Case Study on Ogii Lake Basin in Mongolia
北九州市立大学博士(学術)In this research, the impact of global climate change and human activities on Ogii Lake Basin were studied using RS, and GIS. Ogii Lake and Khugshun Orkhon River’s water was classified as clean and slightly polluted water. The most accurate water index for delineating the surface area of Ogii Lake was MNDWI-1(R=0.94, p < 0.01). Evaporation from the lake was estimated using the energy-budget method based on historical reanalysis (ERA5) daily data. Total annual evaporation from Ogii Lake increased steadily over the last three decades; comparing to 1989, annual evaporation increased by 20.02, 25.79, and 32.4 mm in 1999, 2009, and 2019, respectively. Comparison result showed that precipitation is not a main part of the water source for Ogii Lake. The result of the estimated water balance between 2016 and 2019 was demonstrated that both surface and groundwater have a considerable influence on Ogii Lake’s water balance. The GWPZs of Ogii Lake Basin was delineated integrating the AHP and MCDM methods. The highest GWPZs was coincided with deepest part of the lake, where the tectonic fault cross Ogii Lake.doctoral thesi
The study of bone matrix-derived TGF-beta that acts as a bone coupling factor
研究成果の概要(和文):骨基質中に潜在型で蓄えられ骨吸収によって放出・活性化されるTGF-βは、骨吸収と骨形成のバランスをとるカップリング因子としての働きが期待される。我々は細胞培養系を用いて、放出されたTGF-βが破骨細胞分化と骨吸収を促進することを示した。一方でTGF-βを添加した破骨細胞の培養上清は骨芽細胞分化を促進し、骨細胞のカップリング因子の産生に影響することが示された。この結果から、TGF-βは破骨細胞を介して間接的にカップリング機構に作用することが示唆された。研究成果の概要(英文):TGF-β, which is stored in the latent form in the bone matrix and is released activated by bone resorption, is expected to act as coupling factor that balances bone resorption and bone formation. Using cell culture systems, we showed that released TGF-β promoted osteoclast differentiation and bone resorption. On the other hand, conditioned medium of osteoclasts cultured with TGF-β was shown to promote osteoblastic differentiation and affect the production of osteocyte coupling factors. These results suggest that TGF-β acts on the coupling mechanism via osteoclasts.・2022(令和4)年度 科学研究費補助金 基盤研究(C) 研究成果報告書・研究期間 (年度):2019-04-01 – 2023-03-31・研究分野:分子生物学・研究成果の学術的意義や社会的意義 : 古いカップリング機構の概念は、骨芽細胞と破骨細胞がそれぞれのカップリング因子によって互いの活動量を調節し合うものであった。本研究では骨基質のTGF-βが破骨細胞に作用し、続いて骨芽細胞、骨細胞に影響するという複雑なカップリング機構の存在を示唆している。我々は骨カップリング機構の理解が骨粗鬆症や歯周病などの骨疾患に対する治療法開発の一助になると考える。研究課題/領域番号 : 19K10176research repor
Analysis of Questionnaires focusing on 3rd and 4th-year Students’ Feelings of Satisfaction with Problem-based Learning in Comparison with Lectures in Basic Medicine & Clinical Medicine and Clinical Experiences
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Thoughts on Microscale Experiments in Elementary School Science Classes: An Analysis of Students’ Questionnaires
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