Risk factors for hypersensitivity reactions to tocilizumab introduction in systemic juvenile idiopathic arthritis

浜松医科大学博士（医学）doctoral医学系研究科thesi

松岡熊三郎先生の商法学とその足跡

Articledepartmental bulletin pape

The Issues and Prospects of Regional Museum Practices in Japan as Reviewing Online Seminar “Residents and Regional Museums in Covid-19”

本稿は、新型コロナウイルス感染拡大の影響により延期となった第60回社会教育研究全国集会の代替プログラムとして開催された2020年博物館分科会の学習会「コロナ禍における住民と地域博物館」の開催報告である。同学習会は博物館分科会史上初めてとなるオンライン開催となり、全国各地より延べ75名の参加があった。「コロナ禍」を切り口に語りあった全３回の学習会は、これからの地域博物館の課題と展望を映し出すものとなったといえる。 　2020年の博物館分科会では「コロナ禍」を切り口にオンラインによる協議を開始したが、全国各地の世話人のつながりが再び構築され、社会教育職員である地域博物館の学芸員のあり方、住民自治と地域博物館の相互の関係を理論的かつ実践的に磨きあげていく必要が再確認できた意義は少なくなく、世界や日本の博物館政策の現代的動向を相互に検討する必要も提起される内容となった。departmental bulletin pape

High hydrostatic pressure processing to replace texturizing agents on a plant product intended for altered deglutition: a concept proof

High hydrostatic pressure processing (HPP) can cause changes in food texture. These changes can be beneficial when developing food with strict texture specifications as it is the case of food targeted to people with altered deglutition (AD) issues. The aim of the present research was to evaluate the HPP potential as an alternative to the use of texturizing agents currently added to AD-targeted food products. First, formulation and experimental conditions of treatments were established, and 2 types of chickpea protein pur´ees, one containing corn starch (PS) and the other chicory inulin (PI), were developed. Second, the pur´ees were, in one case HPP-treated (300–400 MPa; 3–9 min) and in the other texturized with agar-agar and xanthan gum. Overall, HPP did not significantly affect the proximate composition of the purées and improved their microbiological quality, and, most importantly, they caused beneficial texture changes on both PS and PI purées. In addition, HPP-treatments conferred similar instrumental texture values to texturized purées. These texture values come within the given specific range data supplied by the literature for AD suitability. The present study provides the basis for applying HPP in the development of texturizer-free AD-oriented purées.The present article was founded by Navarre Government through the Program “Ayudas para la realización de Proyectos Estratégicos de I + D 2021–2024 (ALISSEC project 0011-1411-2021). G. Merino was supported by the Fundación Bancaria Caja Navarra (FBCN) with a doctoral student contract. Open access funding provided by Universidad Pública de Navarra

Base-Excision Repair Mutational Signature in Two Sebaceous Carcinomas of the Eyelid

: Personalized medicine aims to develop tailored treatments for individual patients based on specific mutations present in the affected organ. This approach has proven paramount in cancer treatment, as each tumor carries distinct driver mutations that respond to targeted drugs and, in some cases, may confer resistance to other therapies. Particularly for rare conditions, personalized medicine has the potential to revolutionize treatment strategies. Rare cancers often lack extensive datasets of molecular and pathological information, large-scale trials for novel therapies, and established treatment guidelines. Consequently, surgery is frequently the only viable option for many rare tumors, when feasible, as traditional multimodal approaches employed for more common cancers often play a limited role. Sebaceous carcinoma of the eyelid is an exceptionally rare cancer affecting the eye's adnexal tissues, most frequently reported in Asia, but whose prevalence is significantly increasing even in Europe and the US. The sole established curative treatment is surgical excision, which can lead to significant disfigurement. In cases of metastatic sebaceous carcinoma, validated drug options are currently lacking. In this project, we set out to characterize the mutational landscape of two sebaceous carcinomas of the eyelid following surgical excision. Utilizing available bioinformatics tools, we demonstrated our ability to identify common features promptly and accurately in both tumors. These features included a Base-Excision Repair mutational signature, a notably high tumor mutational burden, and key driver mutations in somatic tissues. These findings had not been previously reported in similar studies. This report underscores how, in the case of rare tumors, it is possible to comprehensively characterize the mutational landscape of each individual case, potentially opening doors to targeted therapeutic options

Evaluation of the space collaboration system : its history, image quality and effectiveness for joint case conference

2000-05A joint case-conference was conducted between the Departments of Radiology at Nagoya and Kobe Universities using the Space Collaboration System (SCS), which connects 39 national universities and institutes by communication satellite. In the conference, both sides presented cases using medical images such as those from CT, MRI, and DSA, and the cases were discussed between participants at the two universities. After the final conference, we distributed a questionnaire to solicit responses from the 43 participating radiologists on the quality of the transferred images and their overall impression of the conference. The responses showed that the CT, MRI, and DSA images were clear enough to allow discussion, whereas the plain X-ray images were not. Hence from the standpoint of image quality, the SCS may be unsuited for medical image diagnosis, but useful for presentation of case images in joint conferences and seminars.departmental bulletin pape

中学校技術・家庭科「エネルギー変換に関する技術」におけるラジオ教材を用いた授業実践

text紀要論文 / Departmental Bulletin Paperdepartmental bulletin pape

Animal-borne soundscape logger as a system for edge classification of sound sources and data transmission for monitoring near-real-time underwater soundscape

The underwater environment is filled with various sounds, with its soundscape composed of biological, geographical, and anthropological sounds. Our work focused on developing a novel method to observe and classify these sounds, enriching our understanding of the underwater ecosystem. We constructed a biologging system allowing near-real-time observation of underwater soundscapes. Utilizing deep-learning-based edge processing, this system classifies the sources of sounds, and upon the tagged animal surfacing, it transmits positional data, results of sound source classification, and sensor readings such as depth and temperature. To test the system, we attached the logger to sea turtles (Chelonia mydas) and collected data through a cellular network. The data provided information on the location-specific sounds detected by the sea turtles, suggesting the possibility to infer the distribution of specific species of organisms over time. The data showed that not only biological sounds but also geographical and anthropological sounds can be classified, highlighting the potential for conducting multi-point and long-term observations to monitor the distribution patterns of various sound sources. This system, which can be considered an autonomous mobile platform for oceanographic observations, including soundscapes, has significant potential to enhance our understanding of acoustic diversity.journal articl

Improved measurements of branching fractions and CP partial rate asymmetries for B-->omegaK and B-->omegapi

journal articl