Nigerian Youths and Popular Music: The Media Literacy Imperative

The pervasiveness of popular music and its attendant influence on contemporary youths in the Nigerian society has attracted the attention of government, parents and researchers. Beyond measures proffer to curb the negative influence of popular music on youths, the youths themselves need to understand the principles and practices of the mass media. Against this backdrop, the study while employing contextual approach and relying largely on secondary data, examines the Nigerian youths and popular music via the media literacy imperative. The paper posits that to ameliorate the negative effects of popular music on Nigerian youths, the youth themselves must have deep understanding of the power of media technology;knowledge about the producers of media contents; and the ability to thoroughly examine media contents (audio visual images), as against the background of the expected role the mass media are to perform in societies. The paper recommends among others the inclusion of media literacy studies in the curriculum of both secondary and tertiary institutions; government linking up with other developed countries to explore the possibility of shutting off the underage from listening! viewing damaging media/musical contents; the interplay of which may probably help to avert a possible dreadful future realities of youths with perverted behaviours (through damaging media/musical content) in the Nigerian society

Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats

2,5-Hexanedione (2,5-HD) is the toxic metabolite of n-hexane which is widely used as solvent in numerous industries. The present study elucidated the precise mechanism of 2,5-HD in hepatorenal toxicity by determining the involvement of oxidative stress in rats. Adult male Wistar rats were exposed to 0, 0.25, 0.5, and 1% 2,5-HD in drinking water for 21 days. Exposure to 2,5-HD caused liver and kidney atrophy evidenced by significant elevation in serum aminotransferases, alkaline phosphatase, albumin, bilirubin, urea, creatinine, and electrolytes levels compared with control. The marked dose-dependent increase in total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) was accompanied with significant decrease in high-density lipoprotein (HDL) levels in 2,5-HD-exposed animals when compared with the control. Administration of 2,5-HD significantly diminished glutathione (GSH) level but increased the activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and glutathione-S-transferase (GST) concomitantly with marked elevation in hydrogen peroxide (H2O2) and malondialdehyde (MDA) levels in liver and kidney of the treated groups compared with control. These findings suggest that undue exposure to 2,5-HD at environmentally relevant levels may impair liver and kidney functions through induction of oxidative stress

Nigerian Youths and Popular Music: The Media Literacy Imperative

The pervasiveness of popular music and its attendant influence on contemporary youths in the Nigerian society has attracted the attention of government, parents and researchers. Beyond measures proffer to curb the negative influence of popular music on youths, the youths themselves need to understand the principles and practices of the mass media. Against this backdrop, the study while employing contextual approach and relying largely on secondary data, examines the Nigerian youths and popular music via the media literacy imperative. The paper posits that to ameliorate the negative effects of popular music on Nigerian youths, the youth themselves must have deep understanding of the power of media technology; knowledge about the producers of media contents; and the ability to thoroughly examine media contents (audio visual images), as against the background of the expected role the mass media are to perform in societies. The paper recommends among others the inclusion of media literacy studies in the curriculum of both secondary and tertiary institutions; government linking up with other developed countries to explore the possibility of shutting off the underage from listening! viewing damaging media/musical contents; the interplay of which may probably help to avert a possible dreadful future realities of youths with perverted behaviours (through damaging media/musical content) in the Nigerian society

Protective capacity of carotenoid trans-astaxanthin in rotenone-induced toxicity in Drosophila melanogaster.

Trans-astaxanthin (TA), a keto-carotenoid found in aquatic invertebrates, possesses anti-oxidative and anti-inflammatory activities. Rotenone is used to induce oxidative stress-mediated Parkinson's disease (PD) in animals. We probed if TA would protect against rotenone-induced toxicity in Drosophila melanogaster. Trans-astaxanthin (0, 0.1, 0.5, 1.0, 2.5, 10, and 20 mg/10 g diet) and rotenone (0, 250 and 500 μM) were separately orally exposed to flies in the diet to evaluate longevity and survival rates, respectively. Consequently, we evaluated the ameliorative actions of TA (1.0 mg/10 g diet) on rotenone (500 μM)-induced toxicity in Drosophila after 7 days' exposure. Additionally, we performed molecular docking of TA against selected pro-inflammatory protein targets. We observed that TA (0.5 and 1.0 mg/10 g diet) increased the lifespan of D. melanogaster by 36.36%. Moreover, TA (1.0 mg/10 g diet) ameliorated rotenone-mediated inhibition of Catalase, Glutathione-S-transferase and Acetylcholinesterase activities, and depletion of Total Thiols and Non-Protein Thiols contents. Trans-astaxanthin prevented behavioural dysfunction and accumulation of Hydrogen Peroxide, Malondialdehyde, Protein Carbonyls and Nitric Oxide in D. melanogaster (p < 0.05). Trans-astaxanthin showed higher docking scores against the pro-inflammatory protein targets evaluated than the standard inhibitors. Conclusively, the structural features of TA might have contributed to its protective actions against rotenone-induced toxicity

“If indeed this is the will of the Ekiti people”

Abstract Based on the idea that the quality of a democracy may be measured against the quality of its public communication, this paper deploys Critical Discourse Analysis (CDA) to investigate a Nigerian gubernatorial concession speech in discursive terms. It argues that as an uncommon genre in political discourse in an emerging democracy this hybridised speech both indexes a growing culture of ‘fair competition’ in Nigeria’s eighteen-year-old civilian rule and presents the incumbent as a deft political actor who strategically claims political capital. The paper examines the text’s generic structure, the political and other actors mentioned or implied in it, its manipulation of pronominal references for rhetorical effect, as well as the epistemic uncertainty implied by a query-concession sequence noticed in it. Drawing on the concession speech literature, the paper charts a course for studying the concession speech as an emerging genre in a neonatal democracy like Nigeria.</jats:p

Induction of oxidative damage in the testes and spermatozoa and hematotoxicity in rats exposed to multiple doses of ethylene glycol monoethyl ether

The effects of ethylene glycol monoethyl ether (EGEE) on the antioxidant systems of the testes and epididymal spermatozoa were investigated in rats at dose levels of 0, 100, 200 and 400 mg kg-1 body weight (bw) administered orally by gavage for 14 consecutive days. The bw gain of the EGEE-treated rats decreased significantly at 200 and 400 mg kg- 1 bw compared with the control group. There were no significant changes in the weights of the testes, epididymis, seminal vesicles and prostate glands of the EGEE-treated rats. In the testes, while EGEE treatment resulted in significant decrease in glutathione (GSH) level, superoxide dismutase (SOD) and catalase (CAT) activities, it markedly increased the malondialdehyde (MDA) level, glutathione-S-transferase (GST) and lactate dehydrogenase (LDH) activities at 200 and 400 mg kg-1 dose levels but vitamin C content remained unaffected in all the groups. In the spermatozoa, administration of EGEE caused significant decrease in the activities of CAT, GST and LDH as well as in the levels of vitamin C and GSH but significantly increased the MDA level and SOD activity compared with the control rats. Histopathological examination showed severe degeneration of the testes, such as generalized erosion and necrosis of the germinal epithelium of the testes, but mildly affected the epididymis at 400 mg kg-1 dose only. Data on spermatozoa analysis of EGEE-treated rats revealed significant decrease in the epididymal spermatozoa number, testicular spermatozoa number, daily spermatozoa production and spermatozoa motility but significantly increased the total spermatozoa abnormalities without affecting the spermatozoa live-dead ratio at all dose levels when compared with the control group. Results of haematological examination showed that white blood cells (WBC), platelets neutrophils and mean corpuscular haemoglobin concentration (MCHC) were significantly lower whereas lymphocytes were increased in 200 and 400 mg/kg EGEE-exposed rats than in the controls. EGEE at 100 mg/kg bw produced minor effect on haematological parameters but adversely affected testes and spermatozoa. In summary, short term administration of EGEE is hematotoxic and gonadotoxic and its effects on male reproduction could be due to the induction of oxidative stress in testes and spermatozoa. </jats:p

Lablab Purpureus Seeds Disrupt Hepatic and Renal Antioxidant Status in Male Rats

Nutrition constitutes an essential aspect of health care in both humans and other animals. Despite the numerous studies conducted on Lablab purpureus seeds, there is a paucity of information on its effects on hepatic and renal antioxidant status. The present study investigated the influence of three varieties of Lablab purpureus seeds (Rongai Brown, Rongai White and Highworth Black) on hepatorenal antioxidant status in male Wistar rats. Group I (control) rats were fed with the standard rat chow for 14 days while Groups II, III and IV rats were separately fed with feed containing the Rongai Brown, Rongai White and Highworth Black for 14 days, respectively. Lablab purpureus caused a significant decrease in renal superoxide dismutase (SOD) but increased hepatic SOD activity along with increased catalase, glutathione- S-transferase and glutathione peroxidase activities in both liver and renal tissues when compared with the control. Moreover, there was a significant decrease in the hepatic glutathione (GSH) level with concomitant elevation in hepatic and renal hydrogen peroxide and lipid peroxidation levels in all Lablab purpureus-fed rats. Lablab purpureus-fed rats demonstrated significant elevations in serum marker enzymes, aspartate aminotransferase and alkaline phosphatase along with increases in urea and creatinine levels. Histopathologically, kidney sections revealed normal renal architecture, whereas treatment-related lesions were identified in the liver of Lablab purpureus-fed rats. This study concluded that consumption of raw Lablab purpureus seeds induced hepatorenal toxicity in rats via the induction of oxidative stress