The Diabetic Dog as a Translational Model for Human Islet Transplantation.

The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols. Recent trends towards the use of monoclonal antibody therapies for immunosuppression in human islet transplantation have led to the increasing use of primate models with induced diabetes. In addition to induced-disease models in large animals, scientists in many fields are considering the use of naturally-occurring disease models in client-owned pets. This article will review the applicability of naturally-occurring diabetes in dogs as a translational model for developing islet transplantation in the human diabetic patient

Learning Materials: The “Nucleus” Of Language Teaching

Among some components of effective language classroom, learning materials indisputably play a focal role. They improve the quality of language teaching; facilitate teachers in doing their duties, and lead students to a higher level of understanding in learning. This research aims to discuss the notion of materials in language teaching. It made use of works of literature to outline the importance of materials in language teaching, and to analyze kinds of materials, which are relevant to language teaching. The analysis resulted in the classification of materials into two broad categories namely (1) created materials, which include course book, audio materials, and video materials; and (2) authentic materials, which cover authentic texts, movie/film, radio broadcasting, television program, graphs, maps, tables, and charts. This paper serves as an invaluable resource to facilitate language teachers in selecting appropriate materials for effective language teaching

Penerapan Safety Management System Pada Lembaga Penyelenggara Pelayanan Navigasi Penerbangan Indonesia

This study aimed to analyze the effect of the implementation of Safety Management System (SMS) and the use of information system on the Flight Safety in the Indonesian Air Navigation Services Organization both partially and simultaneously. The research uses quantitative methods, and the data are analyzed using linear regression, simple correlation both partially and simultaneously and path analysis. The result shows; implementation of Safety Management System (X1) as measured by the Flight Safety (Y) has a positive and significant contribution on the level of Flight Safety. The amount of the application contribution of Safety Management System that directly contributes to the Flight Safety is 35.4%, so the research hypothesis which states that the Safety Management System application directly impacts significantly on Aviation Safety is accepted; the use of Information Systems (X2) as measured by the Flight Safety (Y) has a positive and significant contribution on the level of Flight Safety. The use of information systems contributions that directly contributes to aviation safety is 38.4%, so the hypothesis which states that the use of information system directly affects significantly the flight safety is acceptable; the total effect of simultaneous application of Safety Management System (X1) and the use of Information Systems (X2) contribute significantly to the Flight Safety (Y) as much as 66.3%. The remaining 33.7% is the influence of the other factors such as refresher and development training for air navigation personnel, aviation navigation equipment renewal and observation fligh

The Correlation Between Knowledge with Community Behavior in Antibiotic Use in Kelurahan Petukangan Utara with Home Pharmacy Care

Uncontrolled antibiotics use can induce antibiotics resistance cases. The community believe that antibiotics can cure all disease. Because of that Pharmacist is needed home pharmacy care related by antibiotics use knowledge to justify people's misconceptions. The main purpose of this research to analysis relationship between knowledge of behavior using antibiotics in Kelurahan Petukangan Utara with home pharmacy care. This research is non-experimental with a cross sectional study design. The sample used in this research was the community of Kelurahan Petukangan Utara with cluster random sampling metode is 101 responden by questionnaires. The data analysis used chi-square statistic test. The results showed that there were categories of antibiotic knowledge (55.4%) and antibiotic Behavior (53.5%). There is a significant relationship between knowledge with community behavior antibiotics use with p-value=0.015; OR: 4.979 in Kelurahan Petukangan Utara   &nbsp

Generalized Involution Models for Wreath Products

We prove that if a finite group $H$ has a generalized involution model, as defined by Bump and Ginzburg, then the wreath product $H \wr S_n$ also has a generalized involution model. This extends the work of Baddeley concerning involution models for wreath products. As an application, we construct a Gelfand model for wreath products of the form $A \wr S_n$ with $A$ abelian, and give an alternate proof of a recent result due to Adin, Postnikov, and Roichman describing a particularly elegant Gelfand model for the wreath product \ZZ_r \wr S_n. We conclude by discussing some notable properties of this representation and its decomposition into irreducible constituents, proving a conjecture of Adin, Roichman, and Postnikov's.Comment: 29 page

Determination of Inter-Phase Line Tension in Langmuir Films

A Langmuir film is a molecularly thin film on the surface of a fluid; we study the evolution of a Langmuir film with two co-existing fluid phases driven by an inter-phase line tension and damped by the viscous drag of the underlying subfluid. Experimentally, we study an 8CB Langmuir film via digitally-imaged Brewster Angle Microscopy (BAM) in a four-roll mill setup which applies a transient strain and images the response. When a compact domain is stretched by the imposed strain, it first assumes a bola shape with two tear-drop shaped reservoirs connected by a thin tether which then slowly relaxes to a circular domain which minimizes the interfacial energy of the system. We process the digital images of the experiment to extract the domain shapes. We then use one of these shapes as an initial condition for the numerical solution of a boundary-integral model of the underlying hydrodynamics and compare the subsequent images of the experiment to the numerical simulation. The numerical evolutions first verify that our hydrodynamical model can reproduce the observed dynamics. They also allow us to deduce the magnitude of the line tension in the system, often to within 1%. We find line tensions in the range of 200-600 pN; we hypothesize that this variation is due to differences in the layer depths of the 8CB fluid phases.Comment: See (http://www.math.hmc.edu/~ajb/bola/) for related movie

Special topic: The association between pulse ingredients and canine dilated cardiomyopathy: addressing the knowledge gaps before establishing causation.

In July 2018, the Food and Drug Administration warned about a possible relationship between dilated cardiomyopathy (DCM) in dogs and the consumption of dog food formulated with potatoes and pulse ingredients. This issue may impede utilization of pulse ingredients in dog food or consideration of alternative proteins. Pulse ingredients have been used in the pet food industry for over 2 decades and represent a valuable source of protein to compliment animal-based ingredients. Moreover, individual ingredients used in commercial foods do not represent the final nutrient concentration of the complete diet. Thus, nutritionists formulating dog food must balance complementary ingredients to fulfill the animal's nutrient needs in the final diet. There are multiple factors that should be considered, including differences in nutrient digestibility and overall bioavailability, the fermentability and quantity of fiber, and interactions among food constituents that can increase the risk of DCM development. Taurine is a dispensable amino acid that has been linked to DCM in dogs. As such, adequate supply of taurine and/or precursors for taurine synthesis plays an important role in preventing DCM. However, requirements of amino acids in dogs are not well investigated and are presented in total dietary content basis which does not account for bioavailability or digestibility. Similarly, any nutrient (e.g., soluble and fermentable fiber) or physiological condition (e.g., size of the dog, sex, and age) that increases the requirement for taurine will also augment the possibility for DCM development. Dog food formulators should have a deep knowledge of processing methodologies and nutrient interactions beyond meeting the Association of American Feed Control Officials nutrient profiles and should not carelessly follow unsubstantiated market trends. Vegetable ingredients, including pulses, are nutritious and can be used in combination with complementary ingredients to meet the nutritional needs of the dog