Evaluasi Sistem Informasi Penjualan PT SPNS

The purpose of this paper is to identify and analyze problems that occur in information systems sales PT SPNS. It also serves to control the management and control of applications running well so it can produce accurate information for decision making. The method used is book study method and field study. Study was done by reading library books, scientific papers and other sources, while the field study was done by observation, interviews, and questionnaires. The result of the evaluation is derived from the respective strengths and weaknesses - each control. Weaknesses are found, the findings presented in the form of a matrix that contains the findings and recommendations as a matter of risk remedial action. Conclusions obtained from the audit for security control, operations, limitations, input and output is good enough because it can satisfy and support the sales activities of PT SPNS

Maximum likelihood estimation of cloud height from multi-angle satellite imagery

We develop a new estimation technique for recovering depth-of-field from multiple stereo images. Depth-of-field is estimated by determining the shift in image location resulting from different camera viewpoints. When this shift is not divisible by pixel width, the multiple stereo images can be combined to form a super-resolution image. By modeling this super-resolution image as a realization of a random field, one can view the recovery of depth as a likelihood estimation problem. We apply these modeling techniques to the recovery of cloud height from multiple viewing angles provided by the MISR instrument on the Terra Satellite. Our efforts are focused on a two layer cloud ensemble where both layers are relatively planar, the bottom layer is optically thick and textured, and the top layer is optically thin. Our results demonstrate that with relative ease, we get comparable estimates to the M2 stereo matcher which is the same algorithm used in the current MISR standard product (details can be found in [IEEE Transactions on Geoscience and Remote Sensing 40 (2002) 1547--1559]). Moreover, our techniques provide the possibility of modeling all of the MISR data in a unified way for cloud height estimation. Research is underway to extend this framework for fast, quality global estimates of cloud height.Comment: Published in at http://dx.doi.org/10.1214/09-AOAS243 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Evaluasi Pengendalian Sistem Informasi Pengiriman pada TL

The purpose of this study is to evaluate the control systems on the TL shipping information, in order to discern weaknesses or problems in delivery of enterprise information systems control using CobIT approach. The research method used is the data collecting by observation, checklists, interviews, and literature study. The results achieved are findings and issue recommendations that provide an illustration about a control of the running information delivery systems. From the illustration it is known that on the company\u27s control of information delivery system, there are still many things that have not been up to standard. The conclusion obtained is that the control of information delivery systems that have been implemented meets only partially the standards set small, so it still needs much improvement

Optimal CMB Lensing Reconstruction and Parameter Estimation with SPTpol Data

We perform the first simultaneous Bayesian parameter inference and optimal reconstruction of the gravitational lensing of the cosmic microwave background (CMB), using 100 deg$^2$ of polarization observations from the SPTpol receiver on the South Pole Telescope. These data reach noise levels as low as 5.8 $\mu$K-arcmin in polarization, which are low enough that the typically used quadratic estimator (QE) technique for analyzing CMB lensing is significantly sub-optimal. Conversely, the Bayesian procedure extracts all lensing information from the data and is optimal at any noise level. We infer the amplitude of the gravitational lensing potential to be $A_\phi\,{=}\,0.949\,{\pm}\,0.122$ using the Bayesian pipeline, consistent with our QE pipeline result, but with 17\% smaller error bars. The Bayesian analysis also provides a simple way to account for systematic uncertainties, performing a similar job as frequentist "bias hardening," and reducing the systematic uncertainty on $A_\phi$ due to polarization calibration from almost half of the statistical error to effectively zero. Finally, we jointly constrain $A_\phi$ along with $A_{\rm L}$, the amplitude of lensing-like effects on the CMB power spectra, demonstrating that the Bayesian method can be used to easily infer parameters both from an optimal lensing reconstruction and from the delensed CMB, while exactly accounting for the correlation between the two. These results demonstrate the feasibility of the Bayesian approach on real data, and pave the way for future analysis of deep CMB polarization measurements with SPT-3G, Simons Observatory, and CMB-S4, where improvements relative to the QE can reach 1.5 times tighter constraints on $A_\phi$ and 7 times lower effective lensing reconstruction noise.Comment: 27 pages, 14 figures, accompanying software package available at https://cosmicmar.com/CMBLensing.j

Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer

Adagrasib, an irreversible, selective KRASG12C inhibitor, may be an effective treatment in KRASG12C-mutated colorectal cancer, particularly when combined with an anti-EGFR antibody. In this analysis of the KRYSTAL-1 trial, patients with previously treated KRASG12C-mutated unresectable or metastatic colorectal cancer received adagrasib (600 mg twice daily) plus cetuximab. The primary endpoint was objective response rate (ORR) by blinded independent central review. Ninety-four patients received adagrasib plus cetuximab. With a median follow-up of 11.9 months, ORR was 34.0%, disease control rate was 85.1%, and median duration of response was 5.8 months (95% confidence interval [CI], 4.2-7.6). Median progression-free survival was 6.9 months (95% CI, 5.7-7.4) and median overall survival was 15.9 months (95% CI, 11.8-18.8). Treatment-related adverse events (TRAEs) occurred in all patients; grade 3-4 in 27.7% and no grade 5. No TRAEs led to adagrasib discontinuation. Exploratory analyses suggest circulating tumor DNA may identify features of response and acquired resistance. Significance: Adagrasib plus cetuximab demonstrates promising clinical activity and tolerable safety in heavily pretreated patients with unresectable or metastatic KRASG12C-mutated colorectal cancer. These data support a potential new standard of care and highlight the significance of testing and identification of KRASG12C mutations in patients with colorectal cancer. This article is featured in Selected Articles from This Issue, p. 897

The Design and Integrated Performance of SPT-3G

SPT-3G is the third survey receiver operating on the South Pole Telescope dedicated to high-resolution observations of the cosmic microwave background (CMB). Sensitive measurements of the temperature and polarization anisotropies of the CMB provide a powerful dataset for constraining cosmology. Additionally, CMB surveys with arcminute-scale resolution are capable of detecting galaxy clusters, millimeter-wave bright galaxies, and a variety of transient phenomena. The SPT-3G instrument provides a significant improvement in mapping speed over its predecessors, SPT-SZ and SPTpol. The broadband optics design of the instrument achieves a 430 mm diameter image plane across observing bands of 95 GHz, 150 GHz, and 220 GHz, with 1.2 arcmin FWHM beam response at 150 GHz. In the receiver, this image plane is populated with 2690 dual-polarization, tri-chroic pixels (~16000 detectors) read out using a 68X digital frequency-domain multiplexing readout system. In 2018, SPT-3G began a multiyear survey of 1500 deg$^{2}$ of the southern sky. We summarize the unique optical, cryogenic, detector, and readout technologies employed in SPT-3G, and we report on the integrated performance of the instrument.Comment: 25 pages, 11 figures. Submitted to ApJ

Performance and characterization of the SPT-3G digital frequency-domain multiplexed readout system using an improved noise and crosstalk model

The third generation South Pole Telescope camera (SPT-3G) improves upon its predecessor (SPTpol) by an order of magnitude increase in detectors on the focal plane. The technology used to read out and control these detectors, digital frequency-domain multiplexing (DfMUX), is conceptually the same as used for SPTpol, but extended to accommodate more detectors. A nearly 5x expansion in the readout operating bandwidth has enabled the use of this large focal plane, and SPT-3G performance meets the forecasting targets relevant to its science objectives. However, the electrical dynamics of the higher-bandwidth readout differ from predictions based on models of the SPTpol system. To address this, we present an updated derivation for electrical crosstalk in higher-bandwidth DfMUX systems, and identify two previously uncharacterized contributions to readout noise. The updated crosstalk and noise models successfully describe the measured crosstalk and readout noise performance of SPT-3G, and suggest improvements to the readout system for future experiments using DfMUX, such as the LiteBIRD space telescope