Defining a set of common interprofessional learning competencies for health profession students

Introduction: Increasingly recognized as a core component of contemporary health profession education, interprofessional learning outcomes remain difficult to define and assess across disciplines. The aim of this study was to identify a single set of interprofessional learning competency statements with relevance to all health professions. Methods and results: Six national and international interprofessional competency frameworks were reviewed and combined to give a total of 165 competency statements. Following a process of mapping and grouping these statements into common content areas, duplicate content was removed. In addition, content deemed as a core competency for one or more individual health professions was removed. A round table of experts reviewed the remaining statements and agreed a final set of eight. Each statement was expressed as a specific learning outcome that could be assessed and which described behaviors and practices that students could routinely expect to engage with, and participate in, during the course of their study. Conclusion: Identifying specific interprofessional competencies that students of all health professions require will enable more effective implementation of interprofessional learning activities and assessment within the core curriculum.Maree O'Keefe, Amanda Henderson and Rebecca Chic

Modelling Wind Turbine Wakes at Middelgrunden Wind Farm

This is the author accepted manuscript. The final version is available from the publisher via the URL in this record.As part of the development of an offshore wind farm layout optimisation tool, this paper explores the accuracy and computational time of wake models applied to Middelgrunden Wind Farm outside of Copenhagen, Denmark. In this study, four years of data from 2001 to 2004 are used to test the applicability, accuracy, and computational time of the Jensen, Larsen, Ishihara, and a simplified version of the Ainslie Eddy-Viscosity wake models. This study has shown that the size of the directional sector used in the comparison and if that directional sector is applied to all turbines’ incoming wind velocities or just the northernmost greatly affects the results. From this it is found that the Larsen wake model provides the best balance between accuracy and computational time. It also shows that even a simplified version of a field model takes significantly longer to compute than an analytic model. This study has also shown that using directional sectors of ±15◦ these models perform similarly to previous studies at Nysted and Horns Rev indicating that the close spacing (2.4D) at Middelgrunden is not too close for the use of these models

Application of an offshore wind farm layout optimization methodology at Middelgrunden wind farm

This is the author accepted manuscript. The final version is freely available from Elsevier via the DOI in this record.This article explores the application of a wind farm layout evaluation function and layout optimization framework to Middelgrunden wind farm in Denmark. This framework has been built considering the interests of wind farm developers in order to aid in the planning of future offshore wind farms using the UK Round 3 wind farms as a point of reference to calibrate the model. The present work applies the developed evaluation tool to estimate the cost, energy production, and the levelized cost of energy for the existing as-built layout at Middelgrunden wind farm; comparing these against the cost and energy production reported by the wind farm operator. From here, new layouts have then been designed using either a genetic algorithm or a particle swarm optimizer. This study has found that both optimization algorithms are capable of identifying layouts with reduced levelized cost of energy compared to the existing layout while still considering the specific conditions and constraints at this site and those typical of future projects. Reductions in levelized cost of energy such as this can result in significant savings over the lifetime of the project thereby highlighting the need for including new advanced methods to wind farm layout design.This work is funded in part by the Energy Technologies Institute (ETI) 699 and RCUK energy program for IDCORE (EP/J500847/1)

Soroban: Attributing latency in virtualized environments

Applications running in the cloud have highly-variable response times due to the lack of perfect performance isolation from other services served by common infrastructure. In particular, response latency when executing on a loaded hypervisor or in a container is substantially higher than uncontested bare-metal performance. Whilst efforts to increase performance isolation continue, we present Soroban, a framework for attributing latency to either the cloud provider or their customer. Soroban allows cloud providers to instrument commonly used programs, such as a web server to determine, for each request, how much of the latency is due to the cloud provider, or the consumer. We apply Soroban to a HTTP server and show that it identifies when the cause of latency is due to a provider-induced activity, such as underprovisioning a host, or due to the software run by the customer.This is the author accepted manuscript. The final version is available from USENIX. via https://www.usenix.org/conference/hotcloud15/workshop-program/presentation/sne

Optimisation of Offshore Wind Farms Using a Genetic Algorithm

A modular framework for the optimisation of an offshore wind farm using a discrete genetic algorithm is presented. This approach uses a bespoke grid generation algorithm to define the discrete positions that turbines may occupy thereby implicitly satisfying navigational and search and rescue constraints through the wind farm. The presented methodology takes a holistic approach optimising both the turbine placement and inter-array cable network, while minimising the levelised cost of energy and satisfying real world constraints. This tool therefore integrates models for the assessment of the energy production including wake losses; the optimisation of the inter-array cables; and the estimation of costs of the project over the lifetime. This framework will allow alternate approaches to wake and cost modelling as well as optimisation to be benchmarked in the future

Interaction of reed and acoustic resonator in clarinetlike systems

Sound emergence in clarinetlike instruments is investigated in terms of instability of the static regime. Various models of reed-bore coupling are considered, from the pioneering work of Wilson and Beavers ["Operating modes of the clarinet", J. Acoust. Soc. Am. 56, 653--658 (1974)] to more recent modeling including viscothermal bore losses and vena contracta at the reed inlet. The pressure threshold above which these models may oscillate as well as the frequency of oscillation at threshold are calculated. In addition to Wilson and Beavers' previous conclusions concerning the role of the reed damping in the selection of the register the instrument will play on, the influence of the reed motion induced flow is also emphasized, particularly its effect on playing frequencies, contributing to reduce discrepancies between Wilson and Beavers' experimental results and theory, despite discrepancies still remain concerning the pressure threshold. Finally, analytical approximations of the oscillating solution based on Fourier series expansion are obtained in the vicinity of the threshold of oscillation. This allows to emphasize the conditions which determine the nature of the bifurcation (direct or inverse) through which the note may emerge, with therefore important consequences on the musical playing performances

Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk

We have previously shown that injury-induced neointima formation was rescued by adenoviral-Nogo-B gene delivery. Integrase-competent lentiviral vectors (ICLV) are efficient at gene delivery to vascular cells but present a risk of insertional mutagenesis. Conversely, integrase-deficient lentiviral vectors (IDLV) offer additional benefits through reduced mutagenesis risk, but this has not been evaluated in the context of vascular gene transfer. Here, we have investigated the performance and genetic safety of both counterparts in primary human vascular smooth muscle cells (VSMC) and compared gene transfer efficiency and assessed the genotoxic potential of ICLVs and IDLVs based on their integration frequency and insertional profile in the human genome. Expression of enhanced green fluorescent protein (eGFP) mediated by IDLVs (IDLV-eGFP) demonstrated efficient transgene expression in VSMCs. IDLV gene transfer of Nogo-B mediated efficient overexpression of Nogo-B in VSMCs, leading to phenotypic effects on VSMC migration and proliferation, similar to its ICLV version and unlike its eGFP control and uninfected VSMCs. Large-scale integration site analyses in VSMCs indicated that IDLV-mediated gene transfer gave rise to a very low frequency of genomic integration compared to ICLVs, revealing a close-to-random genomic distribution in VSMCs. This study demonstrates for the first time the potential of IDLVs for safe and efficient vascular gene transfer

Behavior of Petrie Lines in Certain Edge-Transitive Graphs

We survey the construction and classification of one-, two- and infinitely-ended members of a class of highly symmetric, highly connected infinite graphs. In addition, we pose a conjecture concerning the relationship between the Petrie lines and ends of some infinitely-ended members of this class