3D Monte Carlo radiation transfer modelling of photodynamic therapy

We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell as well as the Alfred Stewart Trust.The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.Publisher PD

The impact of teacher professional development on teacher cognition and multilingual teaching practices

This longitudinal case study examined the impact of in-service teacher professional development (PD) on teacher cognition relative to multilingualism and pedagogical practices in linguistically diverse classrooms. Two teachers of English as an additional language (EAL) at a primary school in Norway, who teach large numbers of linguistically and culturally diverse students, participated in twelve workshops that focused on both theoretical and pedagogical aspects of language learning and multilingualism. Drawing on questionnaire and classroom observation data collected during two phases of the project (before and after PD), the findings suggest that the teachers displayed individual trajectories in the development of teacher cognition and practices. While one of the teachers showed considerable change over time, the other one remained more stable, suggesting that individual differences, such as language and family background, education, and teaching experience mediate the impact of PD. Implications for local PD at the site of data collection and broader implications for PD in multilingual contexts are discussed

Effects of Chronotype and Social Jetlag on Blood Biomarkers During WLFF 2-Week Critical Training Period

Chronotype, an individual\u27s natural preference towards activity during certain times of the day, influences the interaction between one\u27s internal circadian rhythms and the external environment. When this is disrupted, it can result in social jet lag (SJL), the misalignment between our sleep/wake schedule on work days and free days. Wildland firefighters grapple with unpredictable and intense demands of their job, making them vulnerable to the challenges posed by SJL. Their duties necessitate abrupt changes in active hours, pushing against their body\u27s inherent circadian preferences. SJL is a behavioral trait that may alter an individual\u27s ability to respond to high stress environments and situations. PURPOSE: To analyze the relationship between chronotype and social jet lag on blood biomarkers during a WLFF 2-week Critical Training period. METHODS: Participants underwent baseline testing which included the Morningness-Eveningness Questionnaire and the Munich Chronotype Questionnaire. Anthropometric measurements were recorded alongside body composition via skinfold measurements. A comprehensive blood draw was conducted to analyze Complete Blood Count. Following baseline assessments, participants entered a 12-day CT period. During this period, daily activity and HR were monitored. Participants maintained a daily training log, sleep log, and completed a Visual Analog Scale for sleep quality and muscle soreness. Upon completion of the CT period, the same measurements as the baseline testing were completed. RESULTS: 25 participants completed the study. Chronotype analysis showed a ME of exercise in lactate dehydrogenase (LDH) and creatine kinase (CK) with both increasing post-CT in intermediate (INT) and morning-types (MT) (p1h of SJL (pCONCLUSION: This data shows that chronotype and SJL had modest effects on blood biomarkers in response to a 2-week CT period but the magnitude of SJL does influence the increase in muscle damage biomarkers. Strategies to mitigate SJL among WLFFs may be necessary to manage the effects of hard training

Comparative Analysis of Pollution in Farmington Bay and the Great Salt Lake, Utah

Farmington Bay covers 94 mi2 (260 km2) in the SW comer of the Great Salt Lake, and is essentially a separate lake because it is enclosed by Antelope Island and a causeway leading to the island from the mainland. The bay has received wastes from the adjoining Salt Lake City metropolitan area for decades. Because of water quality concerns for Farmington 8ay, the Aquatic Ecology Laboratory class at Utah State University studied the bay and a nearby control site (Bridger Bay) in the Great Salt Lake during the fall of 2001. Field sampling and laboratory experiments, as well as other data sources, demonstrated the bay is severely eutrophic and is one of the most polluted water bodies in the state of Utah. A preliminary nutrient loading estimate for the bay indicates that total phosphorus coming into the system is a-times higher than necessary for the bay to be classed as eutrophic. Sewage treatment plants discharging directly to the bay contribute approximately 500/0 of the nutrients. Metrics of eutrophication (chlorophyll, Secchi depth and total phosphorus) all indicated that the bay was hypereutrophic and the combined Trophic State Index was 91, higher than any other lake or reservoir in the state. Oxygen was supersaturated in the surface waters of Farmington Bay during the day, but the bottom water was anoxic. During the night, nearly the entire water column became anoxic due to respiratory demand of the biota. The anoxic conditions allowed high concentrations \u27Of foul-smelling hydrogen sulfide to be produced. Brine shrimp were not abundant in Farmington Bay and the community was dominated by rotifers. In contrast, water quality in Bridger 8ay located on the main lake, was good and brine shrimp were abundant there. Our results, although restricted in scope, corroborate existing monitoring data from this bay. Water quality characteristics in Farmington Bay do not meet those mandated for the protection of aquatic life. Odor problems from the bay likely impact more people than are affected by any other polluted water body in the state. The impact of eutrophication and anoxia on the biota in Farmington Bay may also be substantial, although inadequate data exists to determine these impacts. There are substantial technical challenges to be overcome if water quality in the bay is to be improved to meet its designated use. However, before these technical issues can be solved, the responsible agencies will need to address the problem, and begin studies that may eventually lead to a solution to this serious water quality issue

HPV self-sampling as an alternative strategy in non-attenders for cervical screening – a randomised controlled trial

BACKGROUND: A randomised trial to ascertain whether women who do not attend for cervical screening are more likely to respond to the opportunity to collect a self-sample for human papillomavirus (HPV) testing, or to a further invitation to attend for cervical screening.METHODS: The study was carried out in a Primary Care Trust (PCT) in London between June 2009 and December 2009. In total, 3000 women were randomly selected from persistent non-responders (i. e., who had not responded to at least two invitations to attend for screening). The women were randomised on a 1 : 1 basis to either receive an HPV self-sampling kit or a further invitation to attend for cervical cytology. The main outcome measures were (1) percentage of women attending for cervical cytology compared with those returning a self-sample HPV test or attending for cytology subsequent to receiving the kit and (2) percentage of those testing positive for HPV who attended further investigation.RESULTS: The total response in the self-sampling group for screening was 10.2%. Of the 1500 women in the control group sent a further invitation for cervical screening, 4.5% attended for cytology screening. This difference is highly statistically significant (Po0.0001). Of the 8 women who tested positive for HPV, 7 attended for a cervical smear and had a concurrent colposcopy. Three of these (43%) had high-grade disease (defined as CIN 2+), with one found to have an invasive cancer (stage 1b) and one CIN 3.CONCLUSIONS: The value of this intervention relies on the detection of high-grade CIN and early stage cancer with a good prognosis. The relatively high yield of abnormalities found is consistent with that expected among a hard to reach and relatively high-risk group of women. Our study suggests that self-sampling could increase participation among non-responders in England, but further work is needed to ascertain whether the low response rate seen here is likely to be representative of the rest of the country. Other studies are needed to investigate the response to self-sampling in different demographic and geographic settings. British Journal of Cancer (2011) 104, 915-920. doi: 10.1038/ bjc. 2011.48 www. bjcancer. co

A systematic review of interactive multimedia interventions to promote children's communication with health professionals: implications for communicating with overweight children

Background: Interactive multimedia is an emerging technology that is being used to facilitate interactions between patients and health professionals. The purpose of this review was to identify and evaluate the impact of multimedia interventions (MIs), delivered in the context of paediatric healthcare, in order to inform the development of a MI to promote the communication of dietetic messages with overweight preadolescent children. Of particular interest were the effects of these MIs on child engagement and participation in treatment, and the subsequent effect on health-related treatment outcomes. Methods: An extensive search of 12 bibliographic databases was conducted in April 2012. Studies were included if: one or more child-participant was 7 to 11 years-of-age; a MI was used to improve health-related behaviour; child-participants were diagnosed with a health condition and were receiving treatment for that condition at the time of the study. Data describing study characteristics and intervention effects on communication, satisfaction, knowledge acquisition, changes in self-efficacy, healthcare utilisation, and health outcomes were extracted and summarised using qualitative and quantitative methods. Results: A total of 14 controlled trials, published between 1997 and 2006 met the selection criteria. Several MIs had the capacity to facilitate engagement between the child and a clinician, but only one sought to utilise the MI to improve communication between the child and health professional. In spite of concerns over the quality of some studies and small study populations, MIs were found useful in educating children about their health, and they demonstrated potential to improve children’s health- related self-efficacy, which could make them more able partners in face-to-face communications with health professionals. Conclusions: The findings of this review suggest that MIs have the capacity to support preadolescent child-clinician communication, but further research in this field is needed. Particular attention should be given to designing appropriate MIs that are clinically relevant

Testing for the occurrence of pilchard herpesvirus (PHV) in South African sardine Sardinops sagax

Catches of South African sardine Sardinops sagax have declined in recent years from about 200 000 t harvested annually during the period 2002–2006 to less than 100 000 t. Consequently, some companies are now importing sardine from sources elsewhere in the world to meet local demand for canned sardine and bait. This importation has the potential for the introduction of sardine pathogens, in particular the pilchard herpesvirus (PHV), which could have a negative impact on the currently small South African sardine population. The aims of the current study were to determine whether PHV is present in the local sardine population and to assess the extent to which sardine is being imported into the country and whether imported fish are from countries where the virus is known to be endemic. Fish sampled from South Africa’s western (n = 150), southern (n = 182) and eastern (n = 96) putative stocks of S. sagax were analysed for the presence of PHV using real-time quantitative polymerase chain reaction (qPCR). The origin and amount of potentially infected material imported into South Africa during the period 2010–2014 was also assessed. None of the South African sardine collected during this study tested positive for PHV, suggesting that active PHV was not prevalent in the local population of S. sagax at the time of this study. Between 56 000 and 71 000 t of frozen sardine was imported annually into South Africa from countries where S. sagax occurs, including some from areas (Australia and New Zealand) where sardine infection by PHV is known to be endemic. Hence, it is plausible that the PHV pathogen, capable of perpetuating infections in local sardine populations, could be imported into South Africa along with the importation of frozen sardine. Should local sardine be naïve to the virus, as suggested by this study, then the population is at risk of infection and precautions against such must be taken.DHE

Prognostic Factors and Survival in Pediatric and Adolescent Liposarcoma

Purpose. Liposarcoma is extremely rare in the pediatric population. To identify prognostic factors and determine treatment outcomes, we reviewed our institutional experience with pediatric liposarcoma. Methods. We retrospectively reviewed all pediatric patients (age < 22 years) with confirmed liposarcoma treated at Memorial Sloan-Kettering Cancer Center. Histologic subtype, tumor location, margin status, recurrence, and adjuvant therapy were analyzed and correlated with overall survival. Results. Thirtyfour patients (56% male) with a median age of 18.1 years were identified. Twenty-two (65%) had peripheral tumors and 12 (35%) had centrally located tumors. Histologically, 29 (85%) tumors were low grade, and 5 (15%) were high grade pleomorphic. Eleven (32%) had recurrent disease, 9 patients with central tumors and 2 patients with peripheral lesions. Eight deaths occurred, all in patients with central disease. Five-year overall survival was 78%, with a median follow-up time of 5.4 years (range, 0.3-30.3 years). Tumor grade (P = .003), histologic subtype (P = .01), and primary location (P < .001) all correlated with survival, as did stage (P < .001) and margin status (P = .001). Conclusions. Central location of the primary tumor, high tumor grade, and positive surgical margins are strongly correlated with poor survival in pediatric patients with liposarcoma