Frederick Chopin\u27s Life and Works and It\u27s Influence on Applied Piano Teaching

While many aspects of Frederic Chopin piano technique have been investigated, pedagogical studies regarding his unfinished piano method are certainly lacking. This research focuses on providing first-hand information that will expand the pedagogical philosophy and widen the historical perspective of applied piano students in general. This research project will explore some of practice and historical strategies presented by the nineteenth and twentieth-century pianists in applied lessons to determine how students practice in successive lessons. Frederick Chopin’s innovations on piano technique are extraordinary and influenced succeeding generations of pianists and piano composers. Furthermore, the life and the works of Frederick Chopin have made an undeniable contribution to Polish cultural traditions around the world. This study is based on a hypothesis that argues that some historical aspects of Frederick Chopin’s life and piano method are extremely important for the applied music piano teacher in the twenty-first century. In this study, the writer presents an investigation on Chopin’s historical life events and selected compositions that made Chopin responsible for the development of an innovative applied piano teaching technique. In addition, a qualitative analysis of Chopin’s existing and selected works will be employed for this study. Lastly, by drawing a connection between Chopin’s works and his unfinished piano method, this research study will provide teachers and students with a valuable reference tool when learning how to play his works in a manner that display sensitivity and understanding of the classical piano technique

Modeling a Consortium-based Distributed Ledger Network with Applications for Intelligent Transportation Infrastructure

Emerging distributed-ledger networks are changing the landscape for environments of low trust among participating entities. Implementing such technologies in transportation infrastructure communications and operations would enable, in a secure fashion, decentralized collaboration among entities who do not fully trust each other. This work models a transportation records and events data collection system enabled by a Hyperledger Fabric blockchain network and simulated using a transportation environment modeling tool. A distributed vehicle records management use case is shown with the capability to detect and prevent unauthorized vehicle odometer tampering. Another use case studied is that of vehicular data collected during the event of an accident. It relies on broadcast data collected from the Vehicle Ad-hoc Network (VANET) and submitted as witness reports from nearby vehicles or road-side units who observed the event taking place or detected misbehaving activity by vehicles involved in the accident. Mechanisms for the collection, validation, and corroboration of the reported data which may prove crucial for vehicle accident forensics are described and their implementation is discussed. A performance analysis of the network under various loads is conducted with results suggesting that tailored endorsement policies are an effective mechanism to improve overall network throughput for a given channel. The experimental testbed shows that Hyperledger Fabric and other distributed ledger technologies hold promise for the collection of transportation data and the collaboration of applications and services that consume it

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma

Computational Studies on Organo-catalyzed Selective Acylation of Carbohydrates

To explain the catalyst dependent site-selective acylation of carbohydrates substrates, we utilized density functional theory (DFT) calculations to model the corresponding transition states. In doing so it was discovered that the selectivity of the reactions depends on presence or absence of a cation–n interaction between the cation in the acylated catalyst and an appropriate oxygen lone pair in the substrate. Overall these studies allowed for the construction of a predictive model for site-selectivity which is validated by various substrates

Means, Intent, Lethality, Behaviors, and Psychiatric Diagnosis in Latina Adolescent Suicide Attempters

This article describes the means, intent, lethality, behavioral profiles, and psychiatric diagnoses of adolescent Latina suicide attempters. From a large, mixed-method project studying the sociocultural processes of Latina suicide attempts, we selected 76 participants for this report. In addition to quantitative research data, medical records were available for all 76 participants, as was qualitative data from in-depth interviews for 34 of them. Using the qualitative and quantitative research data, we explored intent and behavioral profiles of the suicidal adolescents. Medical records provided additional information about the means the adolescents used in their attempts, and about their psychiatric diagnoses. The lethality of suicide attempts was coded using the Lethality of Suicide Attempt Rating Scale (LSARS) and the Lethality of Suicide Attempt Rating Scale—Updated (LSARS-II). Findings showed that Latina adolescent suicide attempts are low in lethality. Consistent with the literature, most adolescents reported that they attempted by using means available in their homes (cutting and overdosing with medications were the predominant methods). Interesting discrepancies emerged when comparing adolescents’ self-reported behavioral profiles with clinicians’ psychiatric diagnoses. This report has implications for diagnosis and treatment approaches for both inpatient and outpatient service providers

The Wnt Signaling Antagonist Kremen1 is Required for Development of Thymic Architecture

Wnt signaling has been reported to regulate thymocyte proliferation and selection at several stages during T cell ontogeny, as well as the expression of FoxN1 in thymic epithelial cells (TECs). Kremen1 (Krm1) is a negative regulator of the canonical Wnt signaling pathway, and functions together with the secreted Wnt inhibitor Dickkopf (Dkk) by competing for the lipoprotein receptor-related protein (LRP)-6 co-receptor for Wnts. Here krm1 knockout mice were used to examine krm1 expression in the thymus and its function in thymocyte and TEC development. krm1 expression was detected in both cortical and medullary TEC subsets, as well as in immature thymocyte subsets, beginning at the CD25+CD44+ (DN2) stage and continuing until the CD4+CD8+(DP) stage. Neonatal mice show elevated expression of krm1 in all TEC subsets. krm1− / − mice exhibit a severe defect in thymic cortical architecture, including large epithelial free regions. Much of the epithelial component remains at an immature Keratin 5+ (K5) Keratin 8+(K8) stage, with a loss of defined cortical and medullary regions. A TOPFlash assay revealed a 2-fold increase in canonical Wnt signaling in TEC lines derived from krm1− / − mice, when compared with krm1+ / + derived TEC lines. Fluorescence activated cell sorting (FACS) analysis of dissociated thymus revealed a reduced frequency of both cortical (BP1+EpCAM+) and medullary (UEA-1+ EpCAMhi) epithelial subsets, within the krm1− / − thymus. Surprisingly, no change in thymus size, total thymocyte number or the frequency of thymocyte subsets was detected in krm1− / − mice. However, our data suggest that a loss of Krm1 leads to a severe defect in thymic architecture. Taken together, this study revealed a new role for Krm1 in proper development of thymic epithelium

Layer-Dependent Charge State Lifetime of Single Se Vacancies in WSe2_2

Defect engineering in two-dimensional semiconductors has been exploited to tune the optoelectronic properties and introduce new quantum states in the band gap. Chalcogen vacancies in transition metal dichalcogenides in particular have been found to strongly impact charge carrier concentration and mobility in 2D transistors as well as feature sub-gap emission and single-photon response. In this letter, we investigate the layer-dependent charge state lifetime of Se vacancies in WSe$_2$. In one monolayer WSe$_2$, we observe ultrafast charge transfer from the lowest unoccupied orbital of the top Se vacancy to the graphene substrate within (1.0 $\pm$ 0.2) ps measured via the current saturation in scanning tunneling approach curves. For Se vacancies decoupled by TMD multilayers, we find a sub-exponential increase of the charge lifetime from (62 $\pm$ 14) ps in bilayer to few nanoseconds in four-layer WSe$_2$, alongside a reduction of the defect state binding energy. Additionally, we attribute the continuous suppression and energy shift of the dI/dV in-gap defect state resonances at very close tip--sample distances to a current saturation effect. Our results provide a key measure of the layer-dependent charge transfer rate of chalcogen vacancies in TMDs