Frequency and phase modulation performance of an injection-locked CW magnetron.

It is demonstrated that the output of a 2.45-GHz magnetron operated as a current-controlled oscillator through its pushing characteristic can lock to injection signals in times of the order of 100-500 ns depending on injection power, magnetron heater power, load impedance, and frequency offset of the injection frequency from the natural frequency of the magnetron. Accordingly, the magnetron can follow frequency and phase modulations of the injection signal, behaving as a narrow-band amplifier. The transmission of phase-shift-keyed data at 2 Mb/s has been achieved. Measurements of the frequency response and anode current after a switch of phase as a function of average anode current and heater power give new insight into the locking mechanisms and the noise characteristics of magnetrons

Redevelopment of Al-Gor Shoe Mill : Rochester, New Hampshire

As stated in the thesis project, "Rochester, New Hampshire is a small city of about 30,000 residents. It is located on the east border of New Hampshire, abutting Lebanon, Maine. Rochester is approximately 100 miles due north of Boston, Massachusetts. In years past, the driving forces of Rochester have included industries of shoe and leather production, agriculture, and services. Many of the commercial interests have moved to climates friendlier in temperature and labor. Others have simply folded....The primary goal of this project was to obtain development rights of the Al-Gor Shoe Mill in Rochester, New Hampshire. Secondary goals included utilizing the mill buildings and creating affordable housing and commercial space." (Library-derived description)Robblee, D. A. (1992). Redevelopment of Al-Gor Shoe Mill : Rochester, New Hampshire. Retrieved from http://academicarchive.snhu.eduMaster of Science (M.S.)School of Community Economic Developmen

Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer

The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment. What maintains heterogeneity remains an open question because competition within a tumor leads to a strong selection for the fittest subclone. Cancer cells also cooperate by sharing molecules with paracrine effects, such as growth factors, and heterogeneity can be maintained if subclones depend on each other for survival. Without strict interdependence between subclones, however, nonproducer cells can free-ride on the growth factors produced by neighboring producer cells, a collective action problem known in game theory as the “tragedy of the commons,” which has been observed in microbial cell populations. Here, we report that similar dynamics occur in cancer cell populations. Neuroendocrine pancreatic cancer (insulinoma) cells that do not produce insulin-like growth factor II (IGF-II) grow slowly in pure cultures but have a proliferation advantage in mixed cultures, where they can use the IGF-II provided by producer cells. We show that, as predicted by evolutionary game theory, producer cells do not go extinct because IGF-II acts as a nonlinear public good, creating negative frequency-dependent selection that leads to a stable coexistence of the two cell types. Intratumor cell heterogeneity can therefore be maintained even without strict interdependence between cell subclones. Reducing the amount of growth factors available within a tumor may lead to a reduction in growth followed by a new equilibrium, which may explain relapse in therapies that target growth factors

Buckling of conical shell with local imperfections

Small geometric imperfections in thin-walled shell structures can cause large reductions in buckling strength. Most imperfections found in structures are neither axisymmetric nor have the shape of buckling modes but rather occur locally. This report presents the results of a study of the effect of local imperfections on the critical buckling load of a specific axially compressed thin-walled conical shell. The buckling calculations were performed by using a two-dimensional shell analysis program referred to as the STAGS (Structural Analysis of General Shells) computer code, which has no axisymmetry restrictions. Results show that the buckling load found from a bifurcation buckling analysis is highly dependent on the circumferential arc length of the imperfection type studied. As the circumferential arc length of the imperfection is increased, a reduction of up to 50 percent of the critical load of the perfect shell can occur. The buckling load of the cone with an axisymmetric imperfections is nearly equal to the buckling load of imperfections which extended 60 deg or more around the circumference, but would give a highly conservative estimate of the buckling load of a shell with an imperfection of a more local nature

Nonlinear optical thresholding in a 4-Channel OCDMA system via two-photon absorption

We demonstrate the use of a Two-Photon Absorption based detector in an OCDMA system. This detector provides a significant performance improvement over standard linear detection

Aberrational Effects for Shadows of Black Holes

In this paper, we discuss how the shadow of a Kerr black hole depends on the motion of the observer. In particular, we derive an analytical formula for the boundary curve of the shadow for an observer moving with given four-velocity at given Boyer--Lindquist coordinates. We visualize the shadow for various values of parameters.Comment: 12 pages, 3 figures; Proceedings of the 524. WE-Heraeus-Seminar held at the Physikzentrum, Bad Honnef, Germany, 17.--23.2.201

Alloying effects on the optical properties of Ge1−x_{1-x}Six_x nanocrystals from TDDFT and comparison with effective-medium theory

We present the optical spectra of Ge$_{1-x}$Si$_x$ alloy nanocrystals calculated with time-dependent density-functional theory in the adiabatic local-density ap proximation (TDLDA). The spectra change smoothly as a function of the compositio n $x$. On the Ge side of the composition range, the lowest excitations at the ab sorption edge are almost pure Kohn-Sham independent-particle HOMO-LUMO transitio ns, while for higher Si contents strong mixing of transitions is found. Within T DLDA the first peak is slightly higher in energy than in earlier independent-par ticle calculations. However, the absorption onset and in particular its composit ion dependence is similar to independent-particle results. Moreover, classical depolarization effects are responsible for a very strong suppression of the abs orption intensity. We show that they can be taken into account in a simpler way using Maxwell-Garnett classical effective-medium theory. Emission spectra are in vestigated by calculating the absorption of excited nanocrystals at their relaxe d geometry. The structural contribution to the Stokes shift is about 0.5 eV. Th e decomposition of the emission spectra in terms of independent-particle transit ions is similar to what is found for absorption. For the emission, very weak tra nsitions are found in Ge-rich clusters well below the strong absorption onset.Comment: submitted to Phys. Rev.

Pruritus is a common feature in sheep infected with the BSE agent.

BACKGROUND: The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain, breed, clinical duration, dose, route and type of inoculum and the age at infection. The study aimed to describe the clinical signs in sheep infected with the BSE agent throughout its clinical course to determine whether the clinical signs were as variable as described for classical scrapie in sheep. The clinical signs were compared to BSE-negative sheep to assess if disease-specific clinical markers exist. RESULTS: Forty-seven (34%) of 139 sheep, which comprised 123 challenged sheep and 16 undosed controls, were positive for BSE. Affected sheep belonged to five different breeds and three different genotypes (ARQ/ARQ, VRQ/VRQ and AHQ/AHQ). None of the controls or BSE exposed sheep with ARR alleles were positive. Pruritus was present in 41 (87%) BSE positive sheep; the remaining six were judged to be pre-clinically infected. Testing of the response to scratching along the dorsum of a sheep proved to be a good indicator of clinical disease with a test sensitivity of 85% and specificity of 98% and usually coincided with weight loss. Clinical signs that were displayed significantly earlier in BSE positive cases compared to negative cases were behavioural changes, pruritic behaviour, a positive scratch test, alopecia, skin lesions, teeth grinding, tremor, ataxia, loss of weight and loss of body condition. The frequency and severity of each specific clinical sign usually increased with the progression of disease over a period of 16-20 weeks. CONCLUSION: Our results suggest that BSE in sheep presents with relatively uniform clinical signs, with pruritus of increased severity and abnormalities in behaviour or movement as the disease progressed. Based on the studied sheep, these clinical features appear to be independent of breed, affected genotype, dose, route of inoculation and whether BSE was passed into sheep from cattle or from other sheep, suggesting that the clinical phenotype of BSE is influenced by the TSE strain more than by other factors. The clinical phenotype of BSE in the genotypes and breed studied was indistinguishable from that described for classical scrapie cases