Dimensional analysis of yielding and pounding structures for records without distinct pulses

The seismic response of two fundamental mechanical configurations of earthquake engineering, the elastic–plastic system and the pounding oscillator, is revisited with the aid of dimensional analysis. Starting from the previous work of the authors which focused on pulse-type excitations, the paper offers an alternative, yet physically motivated, way to present the response of yielding and pounding structures under excitations with arbitrary time history. It is shown, that when the appropriate time and length scales are adopted, dimensional analysis can be implemented and remarkable order emerges in the response. Regardless of the acceleration level and frequency content of the excitation, all response spectra become self-similar and when expressed in dimensionless terms, resulting from dimensional analysis, follow a single master curve. The study proposes such scales together with the associated selection criteria among the available in literature strong ground motion parameters and shows that the proposed approach reduces drastically the scatter in the response

France and the EU under Sarkozy: between European ambitions and national objectives?

The early phase of Nicolas Sarkozy's presidency proved highly proactive, particularly during the French presidency of the European Union (EU). However, little of practical import resulted. Moreover, there is much that connects Sarkozy's policies to those of his predecessors. Constrained both at home and abroad, he was sometimes unable to carry through his preferred policies. In addition, Sarkozy has done nothing to resolve a long-standing tension of French EU policy between enormous ambitions for the Union and reluctance to empower its institutions. Intergovernmental co-operation has been the theme linking all of Sarkozy's initiatives. The jury is, of necessity, still out on the long-term impact Sarkozy will have. Early indications are that, whilst there has been no shortage of initiatives, it is open to question whether these either diverge much from those of his predecessors, or will have much impact on the workings and effectiveness of the Union itself

Dimensional analysis of the earthquake-induced pounding between inelastic structures

In this paper the seismic response of inelastic structures with unilateral contact is revisited with dimensional analysis. All physically realizable contact types are captured via a non-smooth complementarity approach. The implementation of formal dimensional analysis leads to a condensed presentation of the response and unveils remarkable order even though two different types of non-linearity coexist in the response: the boundary non-linearity of unilateral contact and the inelastic behaviour of the structure itself. It is shown that regardless the intensity and frequency content of the excitation, all response spectra become self-similar when expressed in the appropriate dimensionless terms. The proposed approach hinges upon the notion of the energetic length scale of an excitation which measures the persistence of ground shaking to impose deformation demands. Using the concept of persistency which is defined for excitations with or without distinct pulses, the response is scaled via meaningful novel intensity measures: the dimensionless gap and the dimensionless yield displacement. The study confirms that contact may have a different effect on the response displacements of inelastic structures depending on the spectral region. In adjacent inelastic structures, such as colliding buildings or interacting bridge segments, contact is likely to alter drastically the excitation frequencies’ at which the system is most vulnerable. Finally, it is shown that the proposed approach yields maximum response displacements which correlate very well with the persistency of real earthquakes for a bridge system with considerably complex behaviour

Deregulation of methylation of transcribed-ultra conserved regions in colorectal cancer and their value for detection of adenomas and adenocarcinomas

Expression of Transcribed Ultraconserved Regions (T-UCRs) is often deregulated in cancer. The present study assesses the expression and methylation of three T-UCRs (Uc160, Uc283 and Uc346) in colorectal cancer (CRC) and explores the potential of T-UCR methylation in circulating DNA for the detection of adenomas and adenocarcinomas. Expression levels of Uc160, Uc283 and Uc346 were lower in neoplastic tissues from 64 CRC patients (statistically significant for Uc160, p<0.001), compared to non-malignant tissues, while methylation levels displayed the inverse pattern (p<0.001, p=0.001 and p=0.004 respectively). In colon cancer cell lines, overexpression of Uc160 and Uc346 led to increased proliferation and migration rates. Methylation levels of Uc160 in plasma of 50 CRC, 59 adenoma patients, 40 healthy subjects and 12 patients with colon inflammation or diverticulosis predicted the presence of CRC with 35% sensitivity and 89% specificity (p=0.016), while methylation levels of the combination of all three T-UCRs resulted in 45% sensitivity and 74.3% specificity (p=0.013). In conclusion, studied T-UCRs’ expression and methylation status are deregulated in CRC while Uc160 and Uc346 appear to have a complicated role in CRC progression. Moreover their methylation status appears a promising non-invasive screening test for CRC, provided that the sensitivity of the assay is improved

Ambipolar charge injection and transport in a single pentacene monolayer island

Electrons and holes are locally injected in a single pentacene monolayer island. The two-dimensional distribution and concentration of the injected carriers are measured by electrical force microscopy. In crystalline monolayer islands, both carriers are delocalized over the whole island. On disordered monolayer, carriers stay localized at their injection point. These results provide insight into the electronic properties, at the nanometer scale, of organic monolayers governing performances of organic transistors and molecular devices.Comment: To be published in Nano Letter

Power, norms and institutional change in the European Union: the protection of the free movement of goods

How do institutions of the European Union change? Using an institutionalist approach, this article highlights the interplay between power, cognitive limits, and the normative order that underpins institutional settings and assesses their impact upon the process of institutional change. Empirical evidence from recent attempts to reinforce the protection of the free movement of goods in the EU suggests that, under conditions of uncertainty, actors with ambiguous preferences assess attempts at institutional change on the basis of the historically defined normative order which holds a given institutional structure together. Hence, path dependent and incremental change occurs even when more ambitious and functionally superior proposals are on offer

Performance of Monolayer Graphene Nanomechanical Resonators with Electrical Readout

The enormous stiffness and low density of graphene make it an ideal material for nanoelectromechanical (NEMS) applications. We demonstrate fabrication and electrical readout of monolayer graphene resonators, and test their response to changes in mass and temperature. The devices show resonances in the MHz range. The strong dependence of the resonant frequency on applied gate voltage can be fit to a membrane model, which yields the mass density and built-in strain. Upon removal and addition of mass, we observe changes in both the density and the strain, indicating that adsorbates impart tension to the graphene. Upon cooling, the frequency increases; the shift rate can be used to measure the unusual negative thermal expansion coefficient of graphene. The quality factor increases with decreasing temperature, reaching ~10,000 at 5 K. By establishing many of the basic attributes of monolayer graphene resonators, these studies lay the groundwork for applications, including high-sensitivity mass detectors

Belowground DNA-based techniques: untangling the network of plant root interactions

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