Tandem aza-Claisen rearrangement and ring closing metathesis reactions: the stereoselective synthesis of functionalised carbocyclic amides

A one-pot, tandem process has been developed for the efficient synthesis of functionalised carbocyclic amides. A substituted cyclopentenyl trichloroacetamide was synthesised using a tandem thermal aza-Claisen rearrangement and RCM process, while an analogous cyclohexenyl trichloroacetamide was generated with high diastereoselectivity using a tandem MOM-ether directed metal-catalysed aza-Claisen rearrangement and RCM process

A template-based approach for the generation of abstractable and reducible models of featured networks

We investigate the relationship between symmetry reduction and inductive reasoning when applied to model checking networks of featured components. Popular reduction techniques for combatting state space explosion in model checking, like abstraction and symmetry reduction, can only be applied effectively when the natural symmetry of a system is not destroyed during specification. We introduce a property which ensures this is preserved, open symmetry. We describe a template-based approach for the construction of open symmetric Promela specifications of featured systems. For certain systems (safely featured parameterised systems) our generated specifications are suitable for conversion to abstract specifications representing any size of network. This enables feature interaction analysis to be carried out, via model checking and induction, for systems of any number of featured components. In addition, we show how, for any balanced network of components, by using a graphical representation of the features and the process communication structure, a group of permutations of the underlying state space of the generated specification can be determined easily. Due to the open symmetry of our Promela specifications, this group of permutations can be used directly for symmetry reduced model checking. The main contributions of this paper are an automatic method for developing open symmetric specifications which can be used for generic feature interaction analysis, and the novel application of symmetry detection and reduction in the context of model checking featured networks. We apply our techniques to a well known example of a featured network – an email system

Regio- and Stereoselective Ruthenium Catalyzed Hydrovinylation of 1,3-Dienes: Application to the Generation of a 20S-Steroidal Sidechain

The addition of ethylene to 1,3-dienes and 1-vinylcycloalkenes, catalyzed by two ruthenium complexes, proceeds in a regioselective fashion to afford 3-methyl-1,4-dienes as products. For a steroidal-based 1-vinylcycloalkene, the addition is stereospecific, giving a product with a 20(S) configuration

Transgender Healthcare Teaching in the Undergraduate Medical School Curriculum

With increasing recognition of the diverse and specific needs of transgender individuals in a health care setting, lack of knowledge, poor attitudes and prejudice towards transgender patients can result in this population being afraid to access medical care. Educating medical students early in their career in a sensitive and inclusive manner could help change these attitudes. It has been shown that medical undergraduates and post-graduates often feel unprepared or uncomfortable in caring for transgender patients due to lack of training and experience2-4. The aim of this study was to address this through introduction of basic transgender healthcare education into the University of Glasgow undergraduate medical curriculum, with the goal of implementing further interactive and fully inclusive teaching

Development of a second order closure model for computation of turbulent diffusion flames

A typical eddy box model for the second-order closure of turbulent, multispecies, reacting flows developed. The model structure was quite general and was valid for an arbitrary number of species. For the case of a reaction involving three species, the nine model parameters were determined from equations for nine independent first- and second-order correlations. The model enabled calculation of any higher-order correlation involving mass fractions, temperatures, and reaction rates in terms of first- and second-order correlations. Model predictions for the reaction rate were in very good agreement with exact solutions of the reaction rate equations for a number of assumed flow distributions

Practices in applied phonics for grade one.

Thesis (Ed.M.)--Boston Universit

Crystal structure of \u3cem\u3ecis\u3c/em\u3e-2-(2-carboxycyclopropyl)-glycine (CCG-III) monohydrate

The title compound, C6H9NO4·H2O [systematic name: (αR,1R,2S)-rel-α-amino-2-carb­oxy­cyclo­propane­acetic acid monohydrate], crystallizes with two organic mol­ecules and two water mol­ecules in the asymmetric unit. The space group is P21 and the organic mol­ecules are enanti­omers, thus this is an example of a `false conglomerate\u27 with two mol­ecules of opposite handedness in the asymmetric unit (r.m.s. overlay fit = 0.056 Å for one mol­ecule and its inverted partner). Each mol­ecule exists as a zwitterion, with proton transfer from the amino acid carb­oxy­lic acid group to the amine group. In the crystal, the components are linked by N-H···O and O-H···O hydrogen bonds, generating (100) sheets. Conformationally restricted glutamate analogs are of inter­est due to their selective activation of different glutamate receptors, and the naturally occurring (+)-CCG-III is an inhibitor of glutamate uptake and the key geometrical parameters are discussed