Improved acoustics for semi-enclosed spaces in the proximity of residential buildings

Continuous urban densification exacerbates acoustic challenges for residents of housing complexes. They are confronted with higher noise immission from railway, road traffic, construction, as well as louder neighborhood acoustic environments. Thereby, not only noise immission indoors is associated with stress, annoyance, and sleep disturbance, but also the immediate outdoor living environment (e.g., courtyards, private gardens and playgrounds, etc.) can be acoustically unpleasant and annoying. This non-exhaustive narrative review paper elaborates on the role of a number of design parameters on improving the quality of the outdoor soundscape of housing complexes: architectural and morphological design, facade material characteristics, balconies, greenery, ground, background sounds, and several factors concerning quality of sounds (e.g., multisensory perception, holistic design, the relevance of space, context, social factors, co-creation, etc.). It mainly covers literature including both acoustical (e.g., sound pressure level and room acoustical parameters) and human/perceptual (e.g., comfort and annoyance) factors. A series of recommendations are presented here as to how the semi-enclosed outdoor spaces in the proximity of residential complexes can be acoustically improved

Neurophysiological evidence for rapid processing of verbal and gestural information in understanding communicative actions

During everyday social interaction, gestures are a fundamental part of human communication. The communicative pragmatic role of hand gestures and their interaction with spoken language has been documented at the earliest stage of language development, in which two types of indexical gestures are most prominent: the pointing gesture for directing attention to objects and the give-me gesture for making requests. Here we study, in adult human participants, the neurophysiological signatures of gestural-linguistic acts of communicating the pragmatic intentions of naming and requesting by simultaneously presenting written words and gestures. Already at ~150 ms, brain responses diverged between naming and request actions expressed by word-gesture combination, whereas the same gestures presented in isolation elicited their earliest neurophysiological dissociations significantly later (at ~210 ms). There was an early enhancement of request-evoked brain activity as compared with naming, which was due to sources in the frontocentral cortex, consistent with access to action knowledge in request understanding. In addition, an enhanced N400-like response indicated late semantic integration of gesture-language interaction. The present study demonstrates that word-gesture combinations used to express communicative pragmatic intentions speed up the brain correlates of comprehension processes – compared with gesture-only understanding – thereby calling into question current serial linguistic models viewing pragmatic function decoding at the end of a language comprehension cascade. Instead, information about the social-interactive role of communicative acts is processed instantaneously

High-latitude dust in the Earth system

Natural dust is often associated with hot, subtropical deserts, but significant dust events have been reported from cold, high latitudes. This review synthesizes current understanding of high-latitude (≥50°N and ≥40°S) dust source geography and dynamics and provides a prospectus for future research on the topic. Although the fundamental processes controlling aeolian dust emissions in high latitudes are essentially the same as in temperate regions, there are additional processes specific to or enhanced in cold regions. These include low temperatures, humidity, strong winds, permafrost and niveo-aeolian processes all of which can affect the efficiency of dust emission and distribution of sediments. Dust deposition at high latitudes can provide nutrients to the marine system, specifically by contributing iron to high-nutrient, low-chlorophyll oceans; it also affects ice albedo and melt rates. There have been no attempts to quantify systematically the expanse, characteristics, or dynamics of high-latitude dust sources. To address this, we identify and compare the main sources and drivers of dust emissions in the Northern (Alaska, Canada, Greenland, and Iceland) and Southern (Antarctica, New Zealand, and Patagonia) Hemispheres. The scarcity of year-round observations and limitations of satellite remote sensing data at high latitudes are discussed. It is estimated that under contemporary conditions high-latitude sources cover >500,000 km2 and contribute at least 80–100 Tg yr−1 of dust to the Earth system (~5% of the global dust budget); both are projected to increase under future climate change scenarios

Compatibility of physical education curricula with physical literacy across 40 European countries

Although the student-centred concept of physical literacy (PL) has been emphasized by UNESCO, knowledge about its adoption/implementation into PE remains scant. Therefore, the goal of this study was to evaluate and compare the compatibility of PE curricula with PL in Europe. We collaboratively gathered a panel of experts encompassing 40 European countries. In the first step, the experts were invited to freely specify the compatibility of country’s PE curricula with PL. The reports were subjected to six-step reflexive thematic analysis. In the second step, we theoretically derived, psychometrically explored, and descriptively analysed 15 curricular-didactical items, each containing a spectrum of statements with high versus no/insufficient PL compatibility. We synthesized both data sources following an explanatory sequential mixed-methods design. While few PE curricula explicitly adhered to PL in Europe, most documents exhibited content and aims marking elements of PL. However, we registered large differences in PL-compatibility between four European regions for the deep structure of the curricula (η2=.27, p=.01). While the quantitative survey suggested no differences in PL compatibility between anglophone versus non-anglophone countries, the qualitative material revealed conceptual and terminological challenges across Europe. The European countries have hesitantly followed the UNESCO call to align PE with the holistic PL concept

GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis

Essential tremor (ET) is a prevalent neurological disorder with a largely unknown underlying biology. In this genome-wide association study meta-analysis, comprising 16,480 ET cases and 1,936,173 controls from seven datasets, we identify 12 sequence variants at 11 loci. Evaluating mRNA expression, splicing, plasma protein levels, and coding effects, we highlight seven putative causal genes at these loci, including CA3 and CPLX1. CA3 encodes Carbonic Anhydrase III and carbonic anhydrase inhibitors have been shown to decrease tremors. CPLX1, encoding Complexin-1, regulates neurotransmitter release. Through gene-set enrichment analysis, we identify a significant association with specific cell types, including dopaminergic and GABAergic neurons, as well as biological processes like Rho GTPase signaling. Genetic correlation analyses reveals a positive association between ET and Parkinson’s disease, depression, and anxiety-related phenotypes. This research uncovers risk loci, enhancing our knowledge of the complex genetics of this common but poorly understood disorder, and highlights CA3 and CPLX1 as potential therapeutic targets

European fitness landscape for children and adolescents: updated reference values, fitness maps and country rankings based on nearly 8 million test results from 34 countries gathered by the FitBack network

Objectives (1) To develop reference values for health-related fitness in European children and adolescents aged 6–18 years that are the foundation for the web-based, open-access and multilanguage fitness platform (FitBack); (2) to provide comparisons across European countries. Methods This study builds on a previous large fitness reference study in European youth by (1) widening the age demographic, (2) identifying the most recent and representative country-level data and (3) including national data from existing fitness surveillance and monitoring systems. We used the Assessing Levels of PHysical Activity and fitness at population level (ALPHA) test battery as it comprises tests with the highest test–retest reliability, criterion/construct validity and health-related predictive validity: the 20 m shuttle run (cardiorespiratory fitness); handgrip strength and standing long jump (muscular strength); and body height, body mass, body mass index and waist circumference (anthropometry). Percentile values were obtained using the generalised additive models for location, scale and shape method. Results A total of 7 966 693 test results from 34 countries (106 datasets) were used to develop sex-specific and age-specific percentile values. In addition, country-level rankings based on mean percentiles are provided for each fitness test, as well as an overall fitness ranking. Finally, an interactive fitness platform, including individual and group reporting and European fitness maps, is provided and freely available online (www.fitbackeurope.eu). Conclusion This study discusses the major implications of fitness assessment in youth from health, educational and sport perspectives, and how the FitBack reference values and interactive web-based platform contribute to it. Fitness testing can be conducted in school and/or sport settings, and the interpreted results be integrated in the healthcare systems across Europe

The Youth Fitness International Test (YFIT) battery for monitoring and surveillance among children and adolescents:A modified Delphi consensus project with 169 experts from 50 countries and territories

Background: Physical fitness in childhood and adolescence is associated with a variety of health outcomes and is a powerful marker of current and future health. However, inconsistencies in tests and protocols limit international monitoring and surveillance. The objective of the study was to seek international consensus on a proposed, evidence-informed, Youth Fitness International Test (YFIT) battery and protocols for health monitoring and surveillance in children and adolescents aged 6–18 years. Methods: We conducted an international modified Delphi study to evaluate the level of agreement with a proposed, evidence-based, YFIT of core health-related fitness tests and protocols to be used worldwide in 6- to 18-year-olds. This proposal was based on previous European and North American projects that systematically reviewed the existing evidence to identify the most valid, reliable, health-related, safe, and feasible fitness tests to be used in children and adolescents aged 6–18 years. We designed a single-panel modified Delphi study and invited 216 experts from all around the world to answer this Delphi survey, of whom one-third are from low-to-middle income countries and one-third are women. Four experts were involved in the piloting of the survey and did not participate in the main Delphi study to avoid bias. We pre-defined an agreement of ≥80% among the expert participants to achieve consensus. Results: We obtained a high response rate (78%) with a total of 169 fitness experts from 50 countries and territories, including 63 women and 61 experts from low- or middle-income countries/territories. Consensus (&gt;85% agreement) was achieved for all proposed tests and protocols, supporting the YFIT battery, which includes weight and height (to compute body mass index as a proxy of body size/composition), the 20-m shuttle run (cardiorespiratory fitness), handgrip strength, and standing long jump (muscular fitness). Conclusion: This study contributes to standardizing fitness tests and protocols used for research, monitoring, and surveillance across the world, which will allow for future data pooling and the development of international and regional sex- and age-specific reference values, health-related cut-points, and a global picture of fitness among children and adolescents.</p

Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadPredicting the pathogenicity of biallelic missense variants can be challenging. Here, we use a deficit of observed homozygous carriers of missense variants, versus an expected number in a set of 153,054 chip-genotyped Icelanders, to identify potentially pathogenic genotypes. We follow three missense variants with a complete deficit of homozygosity and find that their pathogenic effect in homozygous state ranges from severe childhood disease to early embryonic lethality. One of these variants is in CPSF3, a gene not previously linked to disease. From a set of clinically sequenced Icelanders, and by sequencing archival samples targeted through the Icelandic genealogy, we find four homozygous carriers. Additionally, we find two homozygous carriers of Mexican descent of another missense variant in CPSF3. All six homozygous carriers of missense variants in CPSF3 show severe intellectual disability, seizures, microcephaly, and abnormal muscle tone. Here, we show how the absence of certain homozygous genotypes from a large population set can elucidate causes of previously unexplained recessive diseases and early miscarriage.Sacchi Foundatio

Compatibility of physical education curricula with physical literacy across 40 European countries

Although the student-centred concept of physical literacy (PL) has been emphasized by UNESCO, knowledge about its adoption/implementation into PE remains scant. Therefore, the goal of this study was to evaluate and compare the compatibility of PE curricula with PL in Europe. We collaboratively gathered a panel of experts encompassing 40 European countries. In the first step, the experts were invited to freely specify the compatibility of country’s PE curricula with PL. The reports were subjected to six-step reflexive thematic analysis. In the second step, we theoretically derived, psychometrically explored, and descriptively analysed 15 curricular-didactical items, each containing a spectrum of statements with high versus no/insufficient PL compatibility. We synthesized both data sources following an explanatory sequential mixed-methods design. While few PE curricula explicitly adhered to PL in Europe, most documents exhibited content and aims marking elements of PL. However, we registered large differences in PL-compatibility between four European regions for the deep structure of the curricula (η2=.27, p=.01). While the quantitative survey suggested no differences in PL compatibility between anglophone versus non-anglophone countries, the qualitative material revealed conceptual and terminological challenges across Europe. The European countries have hesitantly followed the UNESCO call to align PE with the holistic PL concept