112,993 research outputs found
Nurses\u27 Health Study: Demonstrating the impact of research, and adapting new measures and approaches to increase relevance and effect of cohort studies
Systems Analysis as a Decision-Making Tool for the Library Manager
published or submitted for publicatio
Low-gravity solidification of cast iron and space technology applications
Two types of analyses relating to cast iron solidification were conducted. A theoretical analysis using a computer to predict the cooling versus time relationship throughout the test specimen was performed. Tests were also conducted in a ground-based laboratory to generate a cooling time curve for cast iron. In addition, cast iron was cooled through the solidification period on a KC-135 and an F-104 aircraft while these aircraft were going through a period of low gravity. Future subjects for low gravity tests are enumerated
Anomalous spin-dependent behaviour of one-dimensional subbands
We report a new electron interaction effect in GaAs/AlGaAs quantum wires.
Using DC-bias spectroscopy, we show that large and abrupt changes occur to the
energies of spin-down (lower energy) states as they populate. The effect is not
observed for spin-up energy states. At B=0, interactions have a pronounced
effect, in the form of the well-known 0.7 Structure. However, our new results
show that interactions strongly affect the energy spectrum at all magnetic
fields, from 0 to 16T, not just in the vicinity of the 0.7 Structure.Comment: 4 pages, 2 figure
On the Kropholler conjecture
This short note, produced for the volume of conjectures produced on the occasion of Guido Mislin's retirement, describes the status of the Kropholle conjecture which may be viewed as a far reaching generalisation of Stallings' theorem on groups with more than one end
Persistent homology of groups
We introduce and investigate notions of persistent homology for p-groups and
for coclass trees of p-groups. Using computer techniques we show that
persistent homology provides fairly strong homological invariants for p-groups
of order at most 81. The strength of these invariants, and some elementary
theoretical properties, suggest that persistent homology may be a useful tool
in the study of prime-power groups.Comment: 12 pages, 6 figure
2-pentanone production from hexanoic acid by Penicillium roqueforti from blue cheese:is this the pathway used in humans?
Production of 2-pentanone, a methylketone, is increased in fasting ketotic humans. Its origin is unknown. We hypothesised that it is formed via β-oxidation of hexanoic acid by the peroxisomal pathway proposed for methylketone-producing fungi and yeasts. We used Penicillium roqueforti cultured on fat (margarine) to investigate 2-pentanone production. Headspace gas of incubates of the mould with a range of substrates was analysed using solid-phase microextraction with gas chromatography-mass spectrometry. Consistent with the proposed pathway, 2-pentanone was formed from hexanoic acid, hexanoyl-CoA, hexanoylcarnitine, and ethyl-3-oxohexanoic acid but not from ethylhexanoic, 2-ethylhexanoic, octanoic, or myristic acids, octanoylcarnitine, or pentane. However, the products from deuterated (D) hexanoic-D11 acid and hexanoic-2, 2-D2 acid were 9D- and 2D-2-pentanone, respectively, and not 8D- and 1D-2-pentanone as predicted. When incubated under 18O2/14N2, there was only a very small enrichment of [16O2]- with [18O2]-containing 2-pentanone. These are new observations. They could be explained if hydrogen ions removed from hexanoyl-CoA by acyl-CoA oxidase at the commencement of β-oxidation were cycled through hydrogen peroxide and reentered the pathway through hydration of hexenoyl-CoA. This would protect other proteins from oxidative damage. Formation of 2-pentanone through a β-oxidation cycle similar to Penicillium roqueforti would be consistent with observations in humans
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