207 research outputs found

    Traduzioni polacche della lirica italiana. Spaccato storico

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    Il testo presenta un panorama diacronico delle traduzioni polacche della lirica italiana e la ricezione della letteratura italiana in Polonia, dai tempi antichi fino ai nostri giorn

    Quasi-optimal elimination trees for 2D grids with singularities

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    We construct quasi-optimal elimination trees for 2D finite element meshes with singularities.These trees minimize the complexity of the solution of the discrete system. The computational cost estimates of the elimination process model the execution of the multifrontal algorithms in serial and in parallel shared-memory executions. Since the meshes considered are a subspace of all possible mesh partitions, we call these minimizers quasi-optimal.We minimize the cost functionals using dynamic programming. Finding these minimizers is more computationally expensive than solving the original algebraic system. Nevertheless, from the insights provided by the analysis of the dynamic programming minima, we propose a heuristic construction of the elimination trees that has cost O(log(Ne log(Ne)), where N e is the number of elements in the mesh.We show that this heuristic ordering has similar computational cost to the quasi-optimal elimination trees found with dynamic programming and outperforms state-of-the-art alternatives in our numerical experiments

    The catalytic activity of bimetallic FeCoBEA zeolite catalysts in Fischer-Tropsch synthesis : the role of cobalt in framework position of dealuminated SiBEA zeolite

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    Two series of BEA zeolite modified with transition metals (Co and Fe) with different metals loadings were obtained: the first one was prepared by classical sequential wet impregnation to obtain C-Fex_{x}Coy_{y}AlBEA catalysts; the second one was obtained by a two-step postsynthesis method to design C-Fex_{x}Coy_{y}SiBEA catalysts. The catalytic activity of both series of FeCoBEA zeolite catalysts was determined by the FTS process. These bimetallic catalysts appear to combine the advantages of monometallic cobalt catalysts (lower selectivity towards CO2_{2} than for monometallic iron catalysts) and iron catalysts (lower selectivity towards CH4_{4} than for monometallic cobalt catalysts), while minimizing their disadvantages, such as the large amount of carbon deposition

    Exploring Mechanism of Corrosion Inhibition of WE43 and AZ31 Alloys by 1 Aqueous Molybdate in Hank’s Solution by Multisine Impedimetric Monitoring

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    The concept of utilizing multisine dynamic electrochemical impedance spectroscopy and 25 distribution of relaxation times analysis to monitor effectiveness of a model molybdate inhibitor 26 for AZ31 and WE43 Mg alloys is proposed. The corrosion kinetics and instantaneous values of 27 inhibition efficiency (IE) of molybdate at concentrations up to 150 mM were examined.Предложена концепция использования многосинусоидальной динамической электрохимической импедансной спектроскопии и анализа распределения времен релаксации для мониторинга эффективности модельного молибдатного ингибитора для сплавов AZ31 и WE43 Mg. Были изучены кинетика коррозии и мгновенные значения эффективности ингибирования (ИЭ) молибдата при концентрациях до 150 мМ

    Genome-wide association study of the antibody response to <i>Corynebacterium pseudotuberculosis</i> in sheep

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    Caseous lymphadenitis (CLA) is a chronic and highly contagious disease that is widespread among sheep and goats and adversely affects animal welfare and production. This study aimed to reveal the host genomic influences on Corynebacterium pseudotuberculosis antibody levels as indicators of disease susceptibility or resistance, thereby potentially identifying genetic markers associated with these traits. Blood samples were collected from 321 sheep from four large Czech sheep herds. Animals of the Suffolk breed, ranging in age from 2 to 8 years, were sampled regularly once a year for 4 years. The sheep were classified into healthy and diseased groups based on two different commercial enzyme-linked immunosorbent assay (ELISA) serological antigen tests. Genomic DNA was genotyped with the GeneSeek® Genomic Profiler™ Ovine 50 K, and 41 301 markers were used for the genome-wide association analysis (GWAS). A case–control GWAS including 143 seropositive and 178 seronegative sheep was conducted to assess the relationship between the sheep genome and the antibody response to a phospholipase D antigen of C. pseudotuberculosis using GCTA software. The study revealed two suggestive SNPs (single-nucleotide polymorphisms) on chromosomes 11 and 20, with the most significant SNP in the first exon of the TRIM16 (tripartite-motif-containing 16) gene. By analysing genomic alterations and their context between positive and negative animals, including a gene ontology (GO) analysis of genes within ± 500 kb regions of the suggestive SNPs, we identified genes and immune-related processes and pathways potentially influencing CLA susceptibility. These include antigen processing and presentation of exogenous peptides via major histocompatibility complex (MHC) class I and II, Th17 mucosal cell differentiation, cellular autophagy, and phagosome-related mechanisms. This research provides insights into the genetic basis of the antibody response to C. pseudotuberculosis, identifying suggestive associations and underlying biological mechanisms that could guide future breeding and genetic strategies for improving resistance to CLA in sheep.</p

    Single-lens mass measurement in the high-magnification microlensing event Gaia 19bld located in the Galactic disc

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    CONTEXT: Microlensing provides a unique opportunity to detect non-luminous objects. In the rare cases that the Einstein radius θ_{E} and microlensing parallax π_{E} can be measured, it is possible to determine the mass of the lens. With technological advances in both ground- and space-based observatories, astrometric and interferometric measurements are becoming viable, which can lead to the more routine determination of θ_{E} and, if the microlensing parallax is also measured, the mass of the lens. AIMS: We present the photometric analysis of Gaia19bld, a high-magnification (A ≈ 60) microlensing event located in the southern Galactic plane, which exhibited finite source and microlensing parallax effects. Due to a prompt detection by the Gaia satellite and the very high brightness of I = 9.05 mag at the peak, it was possible to collect a complete and unique set of multi-channel follow-up observations, which allowed us to determine all parameters vital for the characterisation of the lens and the source in the microlensing event. METHODS: Gaia19bld was discovered by the Gaia satellite and was subsequently intensively followed up with a network of ground-based observatories and the Spitzer Space Telescope. We collected multiple high-resolution spectra with Very Large Telescope (VLT)/X-shooter to characterise the source star. The event was also observed with VLT Interferometer (VLTI)/PIONIER during the peak. Here we focus on the photometric observations and model the light curve composed of data from Gaia, Spitzer, and multiple optical, ground-based observatories. We find the best-fitting solution with parallax and finite source effects. We derived the limit on the luminosity of the lens based on the blended light model and spectroscopic distance. RESULTS: We compute the mass of the lens to be 1.13 ± 0.03 M_{⊙} and derive its distance to be 5.52_{−0.64}^{+0.35} kpc. The lens is likely a main sequence star, however its true nature has yet to be verified by future high-resolution observations. Our results are consistent with interferometric measurements of the angular Einstein radius, emphasising that interferometry can be a new channel for determining the masses of objects that would otherwise remain undetectable, including stellar-mass black holes

    Single-lens mass measurement in the high-magnification microlensing event Gaia19bld located in the Galactic disc

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    This work was supported from the Polish NCN grants: Preludium No. 2017/25/N/ST9/01253, Harmonia No. 2018/30/M/ST9/00311, MNiSW grant DIR/WK/2018/12, Daina No. 2017/27/L/ST9/03221, and by the Research Council of Lithuania, grant No. S-LL-19-2. The OGLE project has received funding from the NCN grant MAESTRO 2014/14/A/ST9/00121 to AU. We acknowledge the European Commission’s H2020 OPTICON grant No. 730890. YT acknowledges the support of DFG priority program SPP 1992 “Exploring the Diversity of Extrasolar Planets” (WA 1047/11-1). EB and RS gratefully acknowledge support from NASA grant 80NSSC19K0291. Work by AG was supported by JPL grant 1500811. Work by JCY was supported by JPL grant 1571564. SJF thanks Telescope Live for access to their telescope network. NN acknowledges the support of Data Science Research Center, Chiang Mai University. FOE acknowledges the support from the FONDECYT grant nr. 1201223. MK acknowledges the support from the NCN grant No. 2017/27/B/ST9/02727.Context. Microlensing provides a unique opportunity to detect non-luminous objects. In the rare cases that the Einstein radius θE and microlensing parallax πE can be measured, it is possible to determine the mass of the lens. With technological advances in both ground- and space-based observatories, astrometric and interferometric measurements are becoming viable, which can lead to the more routine determination of θE and, if the microlensing parallax is also measured, the mass of the lens.  Aims. We present the photometric analysis of Gaia19bld, a high-magnification (A approximate to 60) microlensing event located in the southern Galactic plane, which exhibited finite source and microlensing parallax effects. Due to a prompt detection by the Gaia satellite and the very high brightness of I = 9.05 mag at the peak, it was possible to collect a complete and unique set of multi-channel follow-up observations, which allowed us to determine all parameters vital for the characterisation of the lens and the source in the microlensing event.  Methods. Gaia19bld was discovered by the Gaia satellite and was subsequently intensively followed up with a network of ground-based observatories and the Spitzer Space Telescope. We collected multiple high-resolution spectra with Very Large Telescope (VLT)/X-shooter to characterise the source star. The event was also observed with VLT Interferometer (VLTI)/PIONIER during the peak. Here we focus on the photometric observations and model the light curve composed of data from Gaia, Spitzer, and multiple optical, ground-based observatories. We find the best-fitting solution with parallax and finite source effects. We derived the limit on the luminosity of the lens based on the blended light model and spectroscopic distance.  Results. We compute the mass of the lens to be 1.13 ± 0.03 M⊙ and derive its distance to be 5.52-0.64+0.35 kpc. The lens is likely a main sequence star, however its true nature has yet to be verified by future high-resolution observations. Our results are consistent with interferometric measurements of the angular Einstein radius, emphasising that interferometry can be a new channel for determining the masses of objects that would otherwise remain undetectable, including stellar-mass black holes.Publisher PDFPeer reviewe

    Confirmation of a non-synonymous SNP in PNPLA8 as a candidate causal mutation for Weaver syndrome in Brown Swiss cattle

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    Background: Bovine progressive degenerative myeloencephalopathy (Weaver syndrome) is a neurodegenerative disorder in Brown Swiss cattle that is characterized by progressive hind leg weakness and ataxia, while sensorium and spinal reflexes remain unaffected. Although the causal mutation has not been identified yet, an indirect genetic test based on six microsatellite markers and consequent exclusion of Weaver carriers from breeding have led to the complete absence of new cases for over two decades. Evaluation of disease status by imputation of 41 diagnostic single nucleotide polymorphisms (SNPs) and a common haplotype published in 2013 identified several suspected carriers in the current breeding population, which suggests a higher frequency of the Weaver allele than anticipated. In order to prevent the reemergence of the disease, this study aimed at mapping the gene that underlies Weaver syndrome and thus at providing the basis for direct genetic testing and monitoring of today's Braunvieh/Brown Swiss herds. Results: Combined linkage/linkage disequilibrium mapping on Bos taurus chromosome (BTA) 4 based on Illumina Bovine SNP50 genotypes of 43 Weaver-affected, 31 Weaver carrier and 86 Weaver-free animals resulted in a maximum likelihood ratio test statistic value at position 49,812,384 bp. The confidence interval (0.853 Mb) determined by the 2-LOD drop-off method was contained within a 1.72-Mb segment of extended homozygosity. Exploitation of whole-genome sequence data from two official Weaver carriers and 1145 other bulls that were sequenced in Run4 of the 1000 bull genomes project showed that only a non-synonymous SNP (rs800397662) within the PNPLA8 gene at position 49,878,773 bp was concordant with the Weaver carrier status. Targeted SNP genotyping confirmed this SNP as a candidate causal mutation for Weaver syndrome. Genotyping for the candidate causal mutation in a random sample of 2334 current Braunvieh animals suggested a frequency of the Weaver allele of 0.26 %. Conclusions: Through combined use of exhaustive sequencing data and SNP genotyping results, we were able to provide evidence that supports the non-synonymous mutation at position 49,878,773 bp as the most likely causal mutation for Weaver syndrome. Further studies are needed to uncover the exact mechanisms that underlie this syndrome
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