Las anáforas de Cotidiano del Missale hispano-mozarabicum

Las plegarias eucarísticas o anáforas del tiempo De Gotidiano del actual Missale Hispano-Mozarabicum constituyen una fuente de especial significación para el conocimiento de la teología eucarística del rito hispanomozárabe. Lo que aquí se pretende es una breve introducción y presentación de las características fundamentales de las anáforas cotidianas del misal hispano. Con esto, el lector puede adentrarse en los textos anafóricos del tiempo De Gotidiano o de otros tiempos del misal de 1991

What Matters Most to Patients and Rheumatologists? A Discrete Choice Experiment in Rheumatoid Arthritis

Introduction: To determine patient and rheumatologist preferences for rheumatoid arthritis (RA) treatment attributes in Spain and to evaluate their attitude towards shared decision-making (SDM). Methods: Observational, descriptive, exploratory and cross-sectional study based on a discrete choice experiment (DCE). To identify the attributes and their levels, a literature review and two focus groups (patients [P] = 5; rheumatologists [R] = 4) were undertaken. Seven attributes with 2–4 levels were presented in eight scenarios. Attribute utility and relative importance (RI) were assessed using a conditional logit model. Patient preferences for SDM were assessed using an ad hoc questionnaire. Results: Ninety rheumatologists [52.2% women; mean years of experience 18.1 (SD: 9.0); seeing an average of 24.4 RA patients/week (SD: 15.3)] and 137 RA patients [mean age: 47.5 years (SD: 10.7); 84.0% women; mean time since diagnosis of RA: 14.2 years (SD: 11.8) and time in treatment: 13.2 years (SD: 11.2), mean HAQ score 1.2 (SD: 0.7)] participated in the study. In terms of RI, rheumatologists and RA patients viewed: time with optimal QoL: R: 23.41%/P: 35.05%; substantial symptom improvement: R: 13.15%/P: 3.62%; time to onset of treatment action: R: 16.24%/P: 13.56%; severe adverse events: R: 10.89%/P: 11.20%; mild adverse events: R: 4.16%/P: 0.91%; mode of administration: R: 25.23%/P: 25.00%; and added cost: R: 6.93%/P: 10.66%. Nearly 73% of RA patients were involved in treatment decision-making to a greater or lesser extent; however, 27.4% did not participate at all. Conclusion: Both for rheumatologists and patients, the top three decision-making drivers are time with optimal quality, treatment mode of administration and time to onset of action, although in different ranking order. Patients were willing to be more involved in the treatment decision-making process

Temperature and pollution control in flames

We apply control theory for PDEs to flame control. The targeted flame is calculated with complex chemistry. For pollutant control in flames we study both the control of temperature distribution in the flame and flame length at given fuel rate in the flow. Approximate state and sensitivity evaluations as well as mesh adaptation are used to keep the complexity as low as possible and get mesh independent results. In addition, a new recursive semi-deterministic global optimization approach is tested

Implementation and validation of an economic module for the epidemiological model Be-FAST to predict the costs generated by livestock diseases epidemics. Application to the Classical Swine Fever case in Spain.

Classical Swine Fever (CSF) is one of the most harmful livestock di-seases for the economy of the swine sector worldwide. Specifically in Spain, the costs in the two last CSF outbreaks (1997 and 2001) have been estimated above 108 million euros. In this work, we aim to evaluate the economic impact of important livestock disease epidemics, and particularly the CSF in Spain. This study starts with a preliminary classification of the costs associated with CSF epidemics. In order to estimate the expected costs of a given epidemic in a considered area, a new economic module has been integrated into the epidemiological model Be-FAST, a time-spatial stochastic spread mathematical model for studying the transmission of diseases within and between farms. The input data for economic parameters have been obtained from entities related with the swine industry in Spain. The new Be-FAST module is tested by comparing the results obtained with historical data from CSF epidemics in Spain. The outcomes show that severe CSF epidemics also have a strong economic impact with around 80% of the costs related to animal culling, while costs associated with control measures are directly associated with the number of infected farms and the duration of the epidemic. The results presented in this work are expected to provide valuable information to decision makers, including animal health officials and insurance companies, and can be extended to other livestock diseases or used to predict the economic impact of future outbreaks

Inverse problems in high pressure processes and food engineering

Depto. de Análisis Matemático y Matemática AplicadaInstituto de Matemática Interdisciplinar (IMI)Fac. de Ciencias MatemáticasTRUEpu

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

<p><b>Objectives</b> The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features.</p> <p><b>Methods</b> A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, rs844648 and rs12039904) were selected as genetic markers.</p> <p><b>Results</b> A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively). Significant association of the four tested variants with patients with limited cutaneous SSc (lcSSc) was revealed (rs1234314 OR 1.22, 95% CI 1.07 to 1.38; rs844644 OR 0.91, 95% CI 0.83 to 0.99; rs844648 OR 1.10, 95% CI 1.01 to 1.20 and rs12039904 OR 1.20, 95% CI 1.09 to 1.33). Association of rs1234314, rs844648 and rs12039904 minor alleles with patients positive for anti-centromere antibodies (ACA) remained significant (OR 1.23, 95% CI 1.10 to 1.37; OR 1.12, 95% CI 1.01 to 1.25; OR 1.22, 95% CI 1.07 to 1.38, respectively). Haplotype analysis confirmed a protective haplotype associated with SSc, lcSSc and ACA positive subgroups (OR 0.88, 95% CI 0.82 to 0.96; OR 0.88, 95% CI 0.80 to 0.96; OR 0.86, 95% CI 0.77 to 0.97, respectively) and revealed a new risk haplotype associated with the same groups of patients (OR 1.14, 95% CI 1.03 to 1.26; OR 1.20, 95% CI 1.08 to 1.35; OR 1.23, 95% CI 1.07 to 1.42, respectively).</p> <p><b>Conclusions</b> The data confirm the influence of TNFSF4 polymorphisms in SSc genetic susceptibility, especially in subsets of patients positive for lcSSc and ACA.</p&gt

Effect of osteoprotegerin and Dickkopf-related protein 1 on radiological progression in tightly controlled rheumatoid arthritis.

OBJECTIVE: To analyze the association between circulating osteoprotegerin (OPG) and Dickkopf-related protein 1 (DKK-1) and radiological progression in patients with tightly controlled rheumatoid arthritis (RA). METHODS: Serum levels of OPG and DKK-1 were measured in 97 RA patients who were treated according to a treat-to-target strategy (T2T) aimed at remission (DAS28<2.6). Radiologic joint damage progression was assessed by changes in the total Sharp-van der Heijde score (SHS) on serial radiographs of the hands and feet. The independent association between these biomarker levels and the structural damage endpoint was examined using regression analysis. RESULTS: The mean age of the 97 RA patients (68 women) at the time of the study was 54 ± 14 years, and the median disease duration was 1.6 ± 1.5 years. Most patients were seropositive for either RF or ACPA, and the large majority (76%) were in remission or had low disease activity. After a median follow-up time of 3.3 ± 1.5 years (range, 1-7.5 yrs.), the mean total SHS annual progression was 0.88 ± 2.20 units. Fifty-two percent of the patients had no progression (defined as a total SHS of zero). The mean serum OPG level did not change significantly over the study period (from 3.9 ± 1.8 to 4.07 ± 2.23 pmol/L), whereas the mean serum DKK-1 level decreased, although not significantly (from 29.9 ± 10.9 to 23.6 ± 18.8 pmol/L). In the multivariate analysis, the predictive factors increasing the likelihood of total SHS progression were age (OR per year = 1.10; p = 0.003) and a high mean C-reactive protein level over the study period (OR = 1.29; p = 0.005). Circulating OPG showed a protective effect reducing the likelihood of joint space narrowing by 60% (95% CI: 0.38-0.94) and the total SHS progression by 48% (95% CI: 0.28-0.83). The DKK-1 levels were not associated with radiological progression. CONCLUSION: In patients with tightly controlled RA, serum OPG was inversely associated with progression of joint destruction. This biomarker may be useful in combination with other risk factors to improve prediction in patients in clinical remission or low disease activity state

La «liturgia» de la Radical Orthodoxy. Entre Catherine Pickstock y James K. A. Smith

El movimiento teológico «Radical Orthodoxy», considerado a veces como escuela de pensamiento o simplemente como sensibilidad, es uno de los proyectos teológicos contemporáneos más sugerentes del habla inglesa. Entre sus principales características está el concebir la teología como saber omnicomprensivo y su rechazo a la modernidad. La importancia de la «Radical Orthodoxy» para la teología católica contemporánea es su decidida tendencia a la doxología. Pero, ¿cuál es el sentido de la liturgia en este movimiento? ¿A qué forma ritual se refiere? El propósito de esta nota es presentar los elementos fundamentales de la teología litúrgica de la «Radical Orthodoxy», expresados en los libros y artículos de Catherine Pickstock y James K. A. Smith. --------------------------------------------------------------------------- The theological movement «Radical Orthodoxy», sometimes considerate as school of thought or simply as sensibility, is one of the most suggestive theological projects of the English speaking world. Among its features is to conceive the theology as all-embracing knowledge and its rejection of modernity. The importance of «Radical Orthodoxy» for the contemporary Catholic theology is its strong tendency to doxology. But what is the meaning of the liturgy in this movement? What type of ritual mean? The purpose of this note is to present the key elements of the liturgical theology of the «Radical Orthodoxy», expressed in books and articles of Catherine Pick- stock and James K. A. Smith

Economía litúrgica. La ofrenda existencial y el mundo de hoy

Al hablar de la eucaristía como sacrificio nos olvidamos con facilidad del sacrificio de los cristianos. La monición sacerdotal «este sacrificio mío y vuestro» nos indica que, además de existir diferentes niveles de participación, también unimos nuestra existencia al sacrificio del altar. Desde esta eucaristía existencialmiramos también a la ofrenda monetaria y su lugar dentro de la celebración eucarística. Este lugar litúrgico nos da las bases para comprender la acción caritativa dentro de la Iglesia y su dinamismo ofertorial.When talking about the Eucharist as a sacrifice, the sacrifice of Christians is easily left aside. The admonition «my sacrifice and yours» indicates that, besides of there being different levels of participation, we also join our own existence to the sacrifice of the altar. From this existential eucharist we study the monetary offering and its place in the eucharistic celebration. This liturgical place is basic to understand the charitable action within the Church and its offering dynamism