Incidence and predisposing factors of cognitive disorders following off-pump coronary artery bypasses graft surgery

Patients and Methods: A total of 171 patients who had undergone off-pump CABG without any history of psychiatric disorders were enrolled. Samples were selected according to a purposive sampling method. The Mini-Mental State Examination (MMSE) questionnaire was given to each patients to assess the incidence of cognitive disorder during the first 24 hours of surgery in ICU. To compare creatinine, erythrocytes sedimentation rate, extubation time, and patients’ age between those with and those without postoperative cognitive disorder, independent-samplest test was employed. To compare two groups in terms of any history of diseases such as diabetes, hypertension, and hyperlipidemia, and qualitative C-reactive protein (CRP), Chi square test was used. Results: Results showed that 75% of patients had postoperative cognitive disorder. There was a significant association between the history of hypertension, CRP, and preoperative creatinine levels in both cognitive disorder and control groups. Background: Cognitive disorder, which is a common problem for the hospitalized patients, is a fluctuating cognitive destruction that leads to the loss of consciousness. It is usually accompanied by increased mortality, prolonged hospital stay, and decreased rehabilitation. Objectives: The purpose of this study was to determine the risk factors associated with cognitive disorder after coronary artery bypasses graft surgery (CABG). Conclusions: Given the significant prevalence of postoperative cognitive disorder and significant association between the history of hypertension, CRP, and preoperative creatinine and cognitive disorder, the detection of patient’s clinical symptoms may improve diagnosis, treatment, and even prevention of cognitive disorder. © 2014, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM); Published by Kowsar

Denosumab in patients with giant cell tumor and its recurrence: A systematic review

Recent studies suggest that Denosumab reduces tumor size, therefore, makes the surgery easier with lower morbidity. However, some studies have reported several complications for this drug. So, this systematic review was performed to determine the effectiveness and safety of Denosumab in reducing bone destructions activity of giant cell tumor and skeletal-related events (SRE) in affected patients with giant cell tumor of bone (GCTB) and its recurrence. We explored studies in PubMed, and Cochrane Library. For this purpose, articles of various levels were retrieved until October 22, 2016. Two reviewers assessed the articles independently based on predefined criteria to extract the relevant data. Primary outcomes associated with skeletal-related event, overall survival, and secondary outcomes such as pain, quality of life and adverse events were evaluated and analyzed. The total population of this meta-analysis consisted of 686 patients. Of this population, 55 had primary GCTB and 45 had giant cell tumor recurrence, with 2 experiencing secondary recurrence. The results showed the effectiveness of Denosumab in reducing the tumor size due to inhibiting the Osteoclastogenesis. Denosumab didnot show any effect on reducing tumor recurrence, but, in cases where complete tumor surgery is not possible and tumor residuals may remain, Denosumab can be helpful. Also, the clinicians should consider the risk benefit of Denosumab. © 2018 By The Archives of Bone and Joint Surgery

Desempenho per se e parâmetros genéticos de linhagens de trigo com expressão do caráter "stay‑green"

O objetivo deste trabalho foi determinar o desempenho per se e os parâmetros genéticos de caracteres de interesse, em linhagens de trigo que expressam ou não o caráter "stay‑green". O experimento foi conduzido em 2003, 2004 e 2005, em delineamento experimental de blocos ao acaso, com três repetições. Foram avaliadas 32 linhagens irmãs de trigo, 15 com e 17 sem o caráter "stay‑green". As linhagens portadoras desse caráter apresentaram maior produtividade de grãos, maior número de grãos por espiga e menor massa de mil grãos. Além disso, as herdabilidades da produtividade e da massa de grãos foram maiores nessas linhagens, o que revelou menor influência de variações ambientais sobre a expressão desses caracteres. O caráter "stay‑green" contribui para o aumento da produtividade e da estabilidade produtiva do trigo

Taghas

Abstract Under the Islamic (Shiite) institution of Taghas, in case the creditor/owner could not prove his claim before the judge or enforce his rights through the court, in this case, any person who is aware of the credit can enforce the right. This institution which is definable under the framework of objective Unilateral Act, causes temporary ownership for the performer of Taghas in relation to the received right

Deriving Analytical Expressions for the Ideal Curves and Using the Curves to Obtain the Temperature Dependence of Equation-of-State Parameters Analytical Expressions for Ideal Curves 1565

Different equations of state (EOSs) have been used to obtain analytical expressions for the ideal curves, namely, the Joule-Thomson inversion curve (JTIC), Boyle curve (BC), and Joule inversion curve (JIC). The selected EOSs are the Redlich-Kwong (RK), Soave-Redlich-Kwong (SRK), Deiters, linear isotherm regularity (LIR), modified LIR (MLIR), dense system equation of state (DSEOS), and van der Waals (vdW). Analytical expressions have been obtained for the JTIC and BC only by using the LIR, MLIR, and vdW equations of state. The expression obtained using the LIR is the simplest. The experimental data for the JTIC and the calculated points from the empirical EOSs for the BC are well fitted into the derived expression from the LIR, in such a way that the fitting on this expression is better than those on the empirical expressions given by Gunn et al. and Miller. No experimental data have been reported for the BC and JIC; therefore, the calculated curves from different EOSs have been compared with those calculated from the empirical equations. On the basis of the JTIC, an approach is given for obtaining the temperature dependence of an EOS parameter(s). Such an approach has been used to determine the temperature dependences of A 2 of the LIR, a and b parameters of the vdW, and the cohesion function of the RK. Such temperature dependences, obtained on the basis of the JTIC, have been found to be appropriate for other ideal curves as well

In vitro activities of cellulase and ceftazidime, alone and in combination against Pseudomonas aeruginosa biofilms

Background: Biofilms are a main pathogenicity feature of Pseudomonas aeruginosa and has a significant role in antibiotic resistance and persistent infections in humans. We investigated the in vitro activities of antibiotic ceftazidime and enzyme cellulase, either alone or in combination against biofilms of P. aeruginosa. Results: Both ceftazidime and cellulase significantly decreased biofilm formation in all strains in a dose-dependent manner. Combination of enzyme at concentrations of 1.25, 2.5, 5, and 10 U/mL tested with 1/16� MIC of antibiotic led to a significant reduction in biofilm biomass. Cellulase showed a significant detachment effect on biofilms at three concentrations of 10 U/mL, 5 U/mL, and 2.5 U/mL. The MIC, MBC, and MBEC values of ceftazidime were 2 to 4 µg/mL, 4 to 8 µg/mL, and 2048 to 8192 µg/mL. When combined with cellulase, the MBECs of antibiotic showed a significant decrease from 32- to 128-fold. Conclusions: Combination of the ceftazidime and the cellulase had significant anti-biofilm effects, including inhibition of biofilm formation and biofilm eradication in P. aeruginosa. These data suggest that glycoside hydrolase therapy as a novel strategy has the potential to enhance the efficacy of antibiotics and helps to resolve biofilm-associated wound infections caused by this pathogen. © 2021, The Author(s)

Locking plate and fibular strut-graft augmentation in the reconstruction of unicameral bone cyst of proximal femur in the paediatric population

Purpose: Several therapeutic strategies have been used for managing unicameral bone cyst (UBC) of the proximal femur. However, there is insufficient evidence to support one treatment over another, and the optimal treatment is controversial. This study aims at describing our experience with surgical reconstruction of paediatric UBCs of the proximal femur using a proximal locking plate and fibular strut allograft. Methods: In total, 14 consecutive paediatric patients with Dormans types IB (four cases) and IIB (10 cases) UBC were assessed. Mean patient age was 8.6 ± 2.3 years, and mean follow-up period was 41.7 ± 29.8 months. Six patients (42.8) were referred with a pathologic fracture. Clinical/radiological outcome and complication rates were evaluated at the final follow-up session. Results: No cysts were Capanna�s class III (recurrence) or IV (no response). Complete healing (Capanna�s class I) was seen in ten cysts, while four other cysts healed with residual radiolucent areas (Capanna�s class II). Mean healing period was 14.1 ± 5.1 (9�24 months). One patient had superficial infection, one heterotopic ossification, and one mild coxa vara, and mean Musculoskeletal Tumor Society (MSTS) score was 99.5. Conclusion: According to our results, locking plate and fibular strut graft in Dormans classification types IB and IIB results in a favorable outcome in managing UBC of the proximal femur in the paediatric population. © 2017, SICOT aisbl