Anharmonicity changes the solid solubility of an alloy at high temperatures

We have developed a method to accurately and efficiently determine the vibrational free energy as a function of temperature and volume for substitutional alloys from first principles. Taking Ti$_{1-x}$Al$_x$N alloy as a model system, we calculate the isostructural phase diagram by finding the global minimum of the free energy, corresponding to the true equilibrium state of the system. We demonstrate that the anharmonic contribution and temperature dependence of the mixing enthalpy have a decisive impact on the calculated phase diagram of a Ti$_{1-x}$Al$_x$N alloy, lowering the maximum temperature for the miscibility gap from 6560 K to 2860 K. Our local chemical composition measurements on thermally aged Ti$_{0.5}$Al$_{0.5}$N alloys agree with the calculated phase diagram.Comment: 4 pages, 5 figures, supplementary materia

Healthcare prioritisation at the local level: a socio-technical approach

Cost effectiveness analysis is a systematic tool to inform resource allocation decision in healthcare. There is extensive evidence, however, that the tool is difficult to apply in practice, particularly at the level of local health planners, because it is not accessible to those involved in the prioritisation process and not embeds assumptions which are felt to be unacceptable for ethical or other reasons. Pragmatic tools such as Program Budgeting and Marginal Analysis appear to be more suitable for supporting local decisions by engaging stakeholders in a deliberative process. Unlike cost-effectiveness analysis, however, these tools are hard to relate to widely accepted health economic principles. This paper presents a socio-technical approach which draws explicitly on health economic theory and in a practical and reproduceable way through an action research case study with a local healthcare planner of the English National Health Service. Through close and iterative work with those responsible for allocating resources we present a formal model to capture the objectives of the health planners, a communicative procedure and interactive elicitation methods to help key stakeholders to articulate their knowledge and values. The approach proved accessible and acceptable and has been used in making spending decisions

Hubungan Status Gizi Dengan Tekanan Darah Pada Siswa Sekolah Menengah Pertama Negeri 1 Kota Bitung

: According to Riskesdas in 2010, the prevalences of nutritional status based on BMI at age group 13-15 in North Sulawesi were 0.7% very skinny; 5.3% thin; 90, 5% normal; and 3.4% obese. In Indonesia, the incidences of hypertension in adolescents varies from 3.11% to 4.6%. BMI has a strong relationship with blood pressure; BMI >95th percentile was strongly associated with increased blood pressure >90th percentile. This study aimed to determine the relationship of the nutritional status and blood pressure. The study was conducted in SMPN 1 Bitung. This was an analytic obsevational study with a cross-sectional design. Samples were 105 students aged 11-14 years, obtained by using simple random sampling. The nutritional status was defined as independent variables and the blood pressure as the dependent variable. Data were analyzed by using a chi-square test. The results showed that the nutritional status of students were underweight 10.5%, normal 71.4%, overweight 13.3%, and obese 4.8%. The normal blood pressure were found in 89.5%; high normal blood pressure 8.6%; and hypertension 1.9%. The chi-square test results showed a significant relationship between the nutritional status and the blood pressure (P = 0.001). Conclusion: There was a significant relationship between the nutritional status and the blood pressure among the junior high school students in Bitung

PRISMA: Model-driven development of aspect-oriented software architectures

This summary presents a methodology for supporting the development of AOSAs following the MDD paradigm. This new methodology is called PRISMA and allows the code generation from models which specify functional and non-functional requirements

Thermoconditional modulation of the pleiotropic sensitivity phenotype by the Saccharomyces cerevisiae PRP19 mutant allele pso4-1

The conditionally-lethal pso4-1 mutant allele of the spliceosomal-associated PRP19 gene allowed us to study this gene’s influence on pre-mRNA processing, DNA repair and sporulation. Phenotypes related to intron-containing genes were correlated to temperature. Splicing reporter systems and RT–PCR showed splicing efficiency in pso4-1 to be inversely correlated to growth temperature. A single amino acid substitution, replacing leucine with serine, was identified within the N-terminal region of the pso4-1 allele and was shown to affect the interacting properties of Pso4-1p. Amongst 24 interacting clones isolated in a two-hybrid screening, seven could be identified as parts of the RAD2, RLF2 and DBR1 genes. RAD2 encodes an endonuclease indispensable for nucleotide excision repair (NER), RLF2 encodes the major subunit of the chromatin assembly factor I, whose deletion results in sensitivity to UVC radiation, while DBR1 encodes the lariat RNA splicing debranching enzyme, which degrades intron lariat structures during splicing. Characterization of mutagen-sensitive phenotypes of rad2{Delta}, rlf2{Delta} and pso4-1 single and double mutant strains showed enhanced sensitivity for the rad2{Delta} pso4-1 and rlf2{Delta} pso4-1 double mutants, suggesting a functional interference of these proteins in DNA repair processes in Saccharomyces cerevisiae

Dispersive calculation of complex Regge trajectories for the lightest f_2 resonances and the K^∗(892)

We apply a recently developed dispersive formalism to calculate the Regge trajectories of the f_2(1270), f´_ 2(1525) and K^∗(892) mesons. Trajectories are calculated, not fitted to a family of resonances. Assuming that these resonances can be treated in the elastic approximation, the only input are the pole position and residue of a resonance. In all three cases, the predicted Regge trajectories are almost real and linear, with slopes in agreement with the universal value of order 1 GeV_(−2). We also show how these results barely change when considering more than two subtractions in the dispersive formalism

The Impact of Endothall on the Aquatic Plant Community of Kress Lake, Washington

CA dense mat-forming population of Eurasian watermilfoil ( Myriophyllum spicatum L . ) was interfering with fishing and recreation in a small western Washington lake. A low concentration (1.5 mg/L active ingredient) of the herbicide endothall formulated as Aquathol® K was used in 2000 to attempt to selectively control the Eurasian watermilfoil. Aquatic plant biomass and frequency data were collected before treatment, ten weeks after treatment and during the growing season for 3 additional years. Macrophyte data were analyzed to assess the herbicide’s impacts on Eurasian watermilfoil as well as the rest of the aquatic plant community. Results showed a significant decrease in Eurasian watermilfoil biomass and frequency 10 weeks after treatment. The Eurasian watermilfoil continued to be present, but at a significantly reduced level through the remainder of the study (3 years after treatment). Of the native plant species, large-leaf pondweed ( Potamogeton amplifolius Tucker . ) frequency and biomass was significantly reduced after treatment. Common elodea ( Elodea canadensis Rich.), muskgrass ( Chara sp. Vallaint.) and bladderwort ( Utricularia sp. L.) all increased significantly after treatment. (PDF has 6 pages.

Influence of the formulation on double emulsions containing ecological ingredients prepared by a microfluidic technique

Multiple emulsions have significant potential in myriad applications, including foods, cosmetics, drop networks, controlled microreactors, synthesis of microcapsules and drug delivery systems. Great control of multiple-emulsion drops production can be achieved using microfluidic devices. The field of emulsification through microfluidic devices has in recent years become a popular topic of research. In this work, we used a practical approach to make monodisperse double-emulsions drops with an ultrathin middle layer using a single step emulsification in a capillary microfluidic device. The goal of this study was to investigate the influence of different surfactants and additives on stability and droplet size of W/O/W eco-friendly emulsions formulated with a green solvent (D-Limonene). The incorporation of Pluronic F108 destabilised the double emulsions due to a process of precipitation, forming microcapsules. By contrast, there was a necessity to include Span 80 in the formulation in order to achieve stable double emulsions. The addition of rosin gum or silicone oil did not show any improvement in the stability of these complex emulsions. Finally, the formulation used in ultrathin shell microfluidic device did not produce stable double emulsions in the traditional microfluidic device.Las emulsiones múltiples tienen multitud de aplicaciones en la industria alimentaria, cosméticos, microreactores controlados, síntesis de microcápsulas y sistemas de liberación controlada. Se puede conseguir un gran control de la producción de gotas en emulsiones dobles usando técnicas microfluídicas. En este trabajo se desarrollaron emulsiones dobles formuladas con D-Limoneno usando un dispositivo de microfluídica en un solo paso. El D-Limoneno, el componente principal del aceite esencial de naranja, es un monoterpeno natural que tiene propiedades antioxidantes, bactericida, quimiopreventivas y terapéuticas. El objetivo del presente estudio fue investigar la influencia de diferentes tipos de tensioactivos y aditivos en la formulación de emulsiones dobles ecológicas tipo corteza-ultrafina-núcleo sobre la estabilidad física. Las emulsiones dobles tipo corteza ultra fina y núcleo preparadas con Pluronic P108 sufrieron un fenómeno de desestabilización debido a la precipitación de este tensioactivo polimérico creando microcápsulas. Las emulsiones dobles necesitaron un tensioactivo hidrófobo (Span 80) en la fase media para estabilizarlas. Se consiguieron emulsiones dobles estables utilizando Span 80 como tensioactivo en la fase oleosa y PVA en la fase exterior para la configuración tipo corteza ultrafina-núcleo. Estas condiciones no son extrapolables al tradicional dispositivo de microfluídica.Ministerio de Economía y Competitividad del Gobierno de España-CTQ2015-70700-PComisión Europea (Programa FEDER)-CTQ2015-70700-