Treating Homeless Opioid Dependent Patients with Buprenorphine in an Office-Based Setting

CONTEXT Although office-based opioid treatment with buprenorphine (OBOT-B) has been successfully implemented in primary care settings in the US, its use has not been reported in homeless patients. OBJECTIVE To characterize the feasibility of OBOT-B in homeless relative to housed patients. DESIGN A retrospective record review examining treatment failure, drug use, utilization of substance abuse treatment services, and intensity of clinical support by a nurse care manager (NCM) among homeless and housed patients in an OBOT-B program between August 2003 and October 2004. Treatment failure was defined as elopement before completing medication induction, discharge after medication induction due to ongoing drug use with concurrent nonadherence with intensified treatment, or discharge due to disruptive behavior. RESULTS Of 44 homeless and 41 housed patients enrolled over 12 months, homeless patients were more likely to be older, nonwhite, unemployed, infected with HIV and hepatitis C, and report a psychiatric illness. Homeless patients had fewer social supports and more chronic substance abuse histories with a 3- to 6-fold greater number of years of drug use, number of detoxification attempts and percentage with a history of methadone maintenance treatment. The proportion of subjects with treatment failure for the homeless (21%) and housed (22%) did not differ (P=.94). At 12 months, both groups had similar proportions with illicit opioid use [Odds ratio (OR), 0.9 (95% CI, 0.5–1.7) P=.8], utilization of counseling (homeless, 46%; housed, 49%; P=.95), and participation in mutual-help groups (homeless, 25%; housed, 29%; P=.96). At 12 months, 36% of the homeless group was no longer homeless. During the first month of treatment, homeless patients required more clinical support from the NCM than housed patients. CONCLUSIONS Despite homeless opioid dependent patients' social instability, greater comorbidities, and more chronic drug use, office-based opioid treatment with buprenorphine was effectively implemented in this population comparable to outcomes in housed patients with respect to treatment failure, illicit opioid use, and utilization of substance abuse treatment

Searching for New Physics in Leptonic Decays of Bottomonium

New Physics can show up in various well-known processes already studied in the Standard Model, in particular by modifying decay rates to some extent. In this work, I examine leptonic decays of $\Upsilon$ vector resonances of bottomonium below $B\bar{B}$ production, subsequent to a magnetic dipole radiative structural transition of the vector resonance yielding a pseudoscalar continuum state, searching for the existence of a light Higgs-like neutral boson that would imply a slight but experimentally measurable breaking of lepton universality.Comment: LaTeX, 12 pages, 1 EPS figur

The flavor symmetry in the standard model and the triality symmetry

A Dirac fermion is expressed by a 4 component spinor which is a combination of two quaternions and which can be treated as an octonion. The octonion possesses the triality symmetry, which defines symmetry of fermion spinors and bosonic vector fields. The triality symmetry relates three sets of spinors and two sets of vectors, which are transformed among themselves via transformations $G_{23}, G_{12}, G_{13}$, $G_{123}$ and $G_{132}$. If the electromagnetic (EM) interaction is sensitive to the triality symmetry, i.e. EM probe selects one triality sector, EM signals from the 5 transformed world would not be detected, and be treated as the dark matter. According to an astrophysical measurement, the ratio of the dark to ordinary matter in the universe as a whole is almost exactly 5. We expect quarks are insensitive to the triality, and triality will appear as three times larger flavor degrees of freedom in the lattice simulation.Comment: 16 pages 8 figures, To be published in International Journal of Modern Physics

Algebraic properties of Gardner's deformations for integrable systems

An algebraic definition of Gardner's deformations for completely integrable bi-Hamiltonian evolutionary systems is formulated. The proposed approach extends the class of deformable equations and yields new integrable evolutionary and hyperbolic Liouville-type systems. An exactly solvable two-component extension of the Liouville equation is found.Comment: Proc. conf. "Nonlinear Physics: Theory and Experiment IV" (Gallipoli, 2006); Theor. Math. Phys. (2007) 151:3/152:1-2, 16p. (to appear

Breit Hamiltonian and QED Effects for Spinless Particles

We describe a simplified derivation for the relativistic corrections of order $\alpha^4$ for a bound system consisting of two spinless particles. We devote special attention to pionium, the bound system of two oppositely charged pions. The leading quantum electrodynamic (QED) correction to the energy levels is of the order of $\alpha^3$ and due to electronic vacuum polarization. We analyze further corrections due to the self-energy of the pions, and due to recoil effects, and we give a complete result for the scalar-QED leading logarithmic corrections which are due to virtual loops involving only the scalar constituent particles (the pions); these corrections are of order $\alpha^5 \ln \alpha$ for S states.Comment: 12 pages, LaTeX; references added (J. Phys. B, in press

Cusps in K --> 3 pi decays

The pion mass difference generates a pronounced cusp in K --> 3 pi decays. As has recently been pointed out by Cabibbo and Isidori, an accurate measurement of the cusp may allow one to pin down the S-wave pi pi scattering lengths to high precision. Here, we present and illustrate an effective field theory framework that allows one to determine the structure of this cusp in a straightforward manner. The strictures imposed by analyticity and unitarity are respected automatically.Comment: 14 pages, 3 figures, uses Elsevier styl

Integrable Supersymmetry Breaking Perturbations of N=1,2 Superconformal Minimal Models

We display a new integrable perturbation for both N=1 and N=2 superconformal minimal models. These perturbations break supersymmetry explicitly. Their existence was expected on the basis of the classification of integrable perturbations of conformal field theories in terms of distinct classical KdV type hierarchies sharing a common second Hamiltonian structure.Comment: 10 pages (harvmac), LAVAL PHY-20-9

Order alpha^3 ln(1/alpha) Corrections to Positronium Decays

The logarithmically enhanced alpha^3 ln(1/alpha) corrections to the para- and orthopositronium decay widths are calculated in the framework of dimensionally regularized nonrelativistic quantum electrodynamics.In the case of parapositronium, the correction is negative, approximately doubles the effect of the leading logarithmic alpha^3 ln^2(1/alpha) one, and is comparable to the nonlogarithmic O(alpha^2) one. As for orthopositronium, the correction is positive and almost cancels the alpha^3 ln^2(1/alpha) one. The uncertainties in the theoretical predictions for the decay widths are reduced.Comment: 10 pages (Latex); missing term added, corrected coefficient B_p used, numerical results insignificantly change