propnet: A Knowledge Graph for Materials Science

Discovering the ideal material for a new application involves determining its numerous properties, such as electronic, mechanical, or thermodynamic, to match those of its desired application. The rise of high-throughput computation has meant that large databases of material properties are now accessible to scientists. However, these databases contain far more information than might appear at first glance, since many relationships exist in the materials science literature to derive, or at least approximate, additional properties. propnet is a new computational framework designed to help scientists to automatically calculate additional information from their datasets. It does this by constructing a network graph of relationships between different materials properties and traversing this graph. Initially, propnet contains a catalog of over 100 property relationships but the hope is for this to expand significantly in the future, and contributions from the community are welcomed

Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes.

PurposeWe characterize aqueous angiography as a real-time aqueous humor outflow imaging (AHO) modality in cow eyes with two tracers of different molecular characteristics.MethodsCow enucleated eyes (n = 31) were obtained and perfused with balanced salt solution via a Lewicky AC maintainer through a 1-mm side-port. Fluorescein (2.5%) or indocyanine green (ICG; 0.4%) were introduced intracamerally at 10 mm Hg individually or sequentially. With an angiographer, infrared and fluorescent images were acquired. Concurrent anterior segment optical coherence tomography (OCT) was performed, and fixable fluorescent dextrans were introduced into the eye for histologic analysis of angiographically positive and negative areas.ResultsAqueous angiography in cow eyes with fluorescein and ICG yielded high-quality images with segmental patterns. Over time, ICG maintained a better intraluminal presence. Angiographically positive, but not negative, areas demonstrated intrascleral lumens with anterior segment OCT. Aqueous angiography with fluorescent dextrans led to their trapping in AHO pathways. Sequential aqueous angiography with ICG followed by fluorescein in cow eyes demonstrated similar patterns.ConclusionsAqueous angiography in model cow eyes demonstrated segmental angiographic outflow patterns with either fluorescein or ICG as a tracer.Translational relevanceFurther characterization of segmental AHO with aqueous angiography may allow for intelligent placement of trabecular bypass minimally invasive glaucoma surgeries for improved surgical results

Flexible Work and Work Life Balance in the Embroidery Business in Lumban, Philippines

This study documents and examines flexible work arrangements (FWAs) and its implications in the work-life balance of independent workers in the embroidery business in Lumban, Laguna. It considers the nature and history of FWAs and how it evolved into the current work practice in theembroidery business. The study also dwells on the experiences of both embroidery shop owners and embroiderers to realize their exchange relationships in attaining a more or less suitable balance in the demands of work and family through varying work arrangements. Drawing on the social exchange theory (SET), it puts forward that trust, loyalty, commitment and mutual benefits affect their exchange relationships. The study explains how the factors affecting FWAs are perceived to achieve work-life balance among the embroiderers and create valuable utilization of available labor supply

Comparison of the radiographic and functional outcome in pediatric orthopaedic patients with Gartland type II supracondylar fracture treated by operative versus non operative management

Background: The non-operative method of closed reduction and application of long arm posterior splint and the operative method of closed reduction and percutaneous pinning are both putative management for Gartland II supracondylar fracture. The purpose of this study is to compare which method is superior in the management of this type of fracture thru the comparison of the radiographic as well as the functional outcome. Methods: This study includes 51 pediatric patients undergoing supracondylar fracture treatment. The enrolled participants were randomly allocated to one of the two groups to receive either non operative or operative treatment. Radiographic and functional outcome was assessed post treatment. Results: The operative group exhibited significant superiority versus the non operative group as reflected by the results of the post-treatment radiographs utilizing the anterior humeral line while the Baumann’s angle showed no significant difference between the two groups. Moreover, the operative group demonstrated a better Mayo elbow performance score total per follow up, only in the first 3 months but showed no significant difference thereafter. Conclusions: We therefore conclude that non operative and operative management are both effective treatment for Gartland II supracondylar fracture. The operative group showed significant superiority with results of the anterior humeral line falling mostly at the central one-third of the capitellum. The operative group manifested a better Mayo elbow performance score total only during the first 3 months of follow up

Student Encounters with Philippine Embroidery in a Tourism Destination: The Case of Lumban, Laguna

Tourism has been traditionally regarded as a business and management concern. This paper explores how cultural settings can be used to open opportunities for other stakeholders in communities to participate in touristic activities. It aims to contribute to what the authors believe to be the emerging importance of alternative definitions of tourism as a phenomenon. It documents research activities of two academics that did participant observation and interviews in a third-class municipality known for heritage skills in embroidery. Content analysis of field notes obtained months before the off icial start of the university’s semester was done to put structure in an out-of-classroomlearning activity (OCLA) of three sections of undergraduate students. Pre- and post-trip surveys were conducted to gather data on the one-day OCLA. Data obtained from students and local tourism stakeholders were analyzed quantitatively and qualitatively using a culture tourism framework. The paper ends with insights on OCLAs of undergraduate students and a description of how a visit to a destination can uncover meanings that contribute toward understanding of embroidery, self-identity, and embedded meanings of the visited place.Keywords: Embroidery, self-identity, tourism, culture, embedded meanings, tourism stakeholder

La escritura mixta francesa en Santiago de Compostela: evolución, usos y características

"Mixte” was a script that originated in France at the beginning of the 14th century, and which was widespread throughout medieval Europe. However, in the history of the Kingdom of Castile, palaeographers have addressed the question of mixte script within general studies on the medieval writing system, but not in specific studies on this script. Therefore, this study analyses the life of mixte script in the diocese of Santiago de Compostela, covering its history during almost two centuries, its role and the reason for its use in documents, administrative books and diplomatic codices and the formal features of this script, as well as its historical evolution. La mixta fue una escritura surgida en Francia a principios del siglo XIV y que tuvo una gran difusión a lo largo del territorio europeo. No obstante, los trabajos sobre paleografía en la Co-rona de Castilla no han abordado la cuestión de manera particular, sino dentro de aproximaciones generales al ciclo gráfico medieval. Realizamos aquí, pues, un estudio específico de la mixta en la diócesis compostelana, abarcando los casi doscientos años que se mantuvo en uso, la función con que se empleó en documentos, libros administrativos y códices diplomáticos y los elementos formales que la caracterizan, así como su evolución en el plano temporal

Las oficinas de los arcedianos en la diócesis compostelana en los siglos XIV-XVI: escribanías, notarios y documentos

la documentación producida por los arcedianos apenas ha sido estudiada desde el punto de vista de la paleografía y la diplomática, debido, principalmente, al bajo número de fuentes conservadas. A través de más de cincuenta documentos emitidos en pública forma analizaremos, por un lado, las oficinas encargadas de la expedición de diplomas, sus componentes humanos (arcedianos, vicarios y notarios) y sus funciones, así como los procedimientos de elaboración de sus productos escritos. Por otro lado, comprobaremos cuáles fueron las tipologías documentales emitidas en ellas y cómo estas se relacionaron co The palaeographical and diplomatic features of the documents produced for the archdeacons have received little scholarly attention, a neglect due principally to small number of extant texts. Drawing on a collection of more than fifty documents, we analyse the offices where documents were issued, their staff (archdeacons, officials, and notaries), and their functions as well as how documents were drawn up. We also analyse the types of documents issued in these offices and how these were related to their physical features (the scripts, the writing medium, and the language). © 2022 Universidad Compultense Madrid. All right reserved

Las colecciones de documentos bajomedievales de las diócesis de Braga y Tui como fuente de estudio para la historia de la frontera gráfica

The graphic culture of border territories became a complex historical reality due to the flow of people and the cultural and social influences which converged in these spaces. Consequently, this fact determined the type of documents which were issued, their formal elements or the types of scripts employed. In this research we shall present some of the collections of documents of the Arquivo Distrital de Braga and the Archivo Catedralicio de Tui which make it possible to study the graphic border between these two dioceses during the 14th and 15th centuries and the possibilities provided by the comparative analysis of some of their palaeographical and diplomatical features.La cultura gráfica en los territorios de frontera se convirtió en una realidad histórica muy compleja debido a los flujos de población e influencias culturales y sociales que convergieron en estos espacios; lo cual, además, determinó los tipos de documentos producidos, sus elementos formales o los modelos gráficos utilizados. En esta investigación presentamos algunos de los fondos documentales de los archivos Distrital de Braga y Catedralicio de Tui que nos permiten estudiar la frontera gráfica entre estas dos diócesis en los siglos XIV y XV y las posibilidades ofrecidas por el análisis comparativo de ciertos aspectos paleográficos y diplomáticos de sus componentes

Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer

BACKGROUND. Monocarboxylate transporters (MCTs) are transmembrane proteins involved in the transport of monocarboxylates across the plasma membrane, which appear to play an important role in solid tumours, however the role of MCTs in prostate cancer is largely unknown.The aim of the present work was to evaluate the clinico-pathological value of monocarboxylate transporters (MCTs) expression, namely MCT1, MCT2 and MCT4, together with CD147 and gp70 as MCT1/4 and MCT2 chaperones, respectively, in prostate carcinoma. METHODS. Prostate tissues were obtained from 171 patients, who performed radical prostatectomy and 14 patients who performed cystoprostatectomy. Samples and clinico-pathological data were retrieved and organized into tissue microarray (TMAs) blocks. Protein expression was evaluated by immunohistochemistry in neoplastic (n= 171), adjacent non-neoplastic tissues (n= 135), PIN lesions (n=40) and normal prostatic tissue (n=14). Protein expression was correlated with patients' clinicopathologic characteristics. RESULTS. In the present study, a significant increase of MCT2 and MCT4 expression in the cytoplasm of tumour cells and a significant decrease in both MCT1 and CD147 expression in prostate tumour cells was observed when compared to normal tissue. All MCT isoforms and CD147 were expressed in PIN lesions. Importantly, for MCT2 and MCT4 the expression levels in PIN lesions were between normal and tumour tissue, which might indicate a role for these MCTs in the malignant transformation. Associations were found between MCT1, MCT4 and CD147 expressions and poor prognosis markers; importantly MCT4 and CD147 overexpression correlated with higher PSA levels, Gleason score and pT stage, as well as with perineural invasion and biochemical recurrence. CONCLUSIONS. Our data provides novel evidence for the involvement of MCTs in prostate cancer. According to our results, we consider that MCT2 should be further explored as tumour marker and both MCT4 and CD147 as markers of poor prognosis in prostate cancer.NPG, CP and VMG received fellowships from the Portuguese Foundation for Science and Technology (FCT), refs. SFRH/BD/61027/2009, SFRH/BPD/69479/ 2010 and SFRH/BI/33503/2008, respectively. This work was supported by the FCT grant ref. PTDC/SAU-FCF/104347/2008, under the scope of Programa Operacional Temático Factores de Competitividade” (COMPETE) of Quadro Comunitário de Apoio III and co-financed by Fundo Comunitário Europeu FEDER