Bioaccumulation of PCB & DDE methyl sulfones in marine mammals and their interactions with receptor proteins

PCB and DDE-Methyl sulphone metabolites are the product of enzymatic and bile acid entero hepatic metabolism in the final phase (III) of PCB and DDE detoxification in mammals following hepatic microsomal cytochrome P450-dependent metabolism (phase I) and conjugation (phase II). There is good evidence that PCB and DDE methyl sulphone (MSF) metabolites interfere with steroid binding to a receptor protein in uterine epithelium (uteroglobin - UG2 and bronchial epithelium (clara cell secretory protein - CCSP). UG and CCSP are homologous 16,000 Da proteins with different tissue-specific functions. UG binds progesterone in the pre-implantation uterus to signal localised endometrial thickening and capillary formation, vital for successful attachment of the fertilised embryo. PCB-MSFs can displace progesterone in the mammalian uterus due to their higher affinity for UG, resulting in implantation failure or early fetal death. CCSP however, functions to sequester phospholipase A2 (PLA2) released in response to stress (pathogenic infection / injury) to suppress inflammatory responses triggered by PLA2 in bronchial epithelium. CCSP is also known as retinol-binding protein (RBP) transporting retinol (vit A) to target epithelia for a functional immune response*. Studies with Harbour Seals demonstrated displacement of retinol from RBP by hydroxy-PCB metabolites resulting in immunosuppression. PCB-MSFs have been shown to accumulate in clara cells and uterine epithelium in laboratory radioactive tracer studies and CCSP-knock out studies with mice. PCB and DDE -MSFs burdens have been found in marine mammals, suggesting they may be subject to reproductive and immuno-toxic effects of these metabolites. This study determines PCB and DDE-MSFs burdens in tissues (including lung & uterus) of Harbour Seal (Phoca vitulina) and Striped Dolphin (Stenella coeruleoalba) morbillivirus victims and characterises the marine mammalian UG/CCSP protein

RXTE and BeppoSAX Observations of MCG -5-23-16: Reflection From Distant Cold Material

We examine the spectral variability of the Seyfert 1.9 galaxy MCG -5-23-16 using RXTE and BeppoSAX observations spanning 2 years from April 1996 to April 1998. During the first year the X-ray source brightens by a factor of ~25% on timescales of days to months. During this time, the reprocessed continuum emission seen with RXTE does not respond measurably to the continuum increase. However, by the end of the second year during the BeppoSAX epoch the X-ray source has faded again. This time, the reprocessed emission has also faded, indicating that the reprocessed flux has responded to the continuum. If these effects are caused by time delays due to the distance between the X-ray source and the reprocessing region, we derive a light crossing time of between ~1 light day and ~1.5 light years. This corresponds to a distance of 0.001 pc to 0.55 pc, which implies that the reprocessed emission originates between 3x10^15 cm and 1.6x10^18 cm from the X-ray source. In other words, the reprocessing in MCG -5-23-16 is not dominated by the inner regions of a standard accretion disk.Comment: Accepted for publication in ApJ. 17 pages, 8 figure

Epitaxial Growth of an n-type Ferromagnetic Semiconductor CdCr2Se4 on GaAs(001) and GaP(001)

We report the epitaxial growth of CdCr2Se4, an n-type ferromagnetic semiconductor, on both GaAs and GaP(001) substrates, and describe the structural, magnetic and electronic properties. Magnetometry data confirm ferromagnetic order with a Curie temperature of 130 K, as in the bulk material. The magnetization exhibits hysteretic behavior with significant remanence, and an in-plane easy axis with a coercive field of ~125 Oe. Temperature dependent transport data show that the films are semiconducting in character and n-type as grown, with room temperature carrier concentrations of n ~ 1 x 10^18 cm-3.Comment: 12 pages, 3 figure

Earth-like sand fluxes on Mars

Strong and sustained winds on Mars have been considered rare, on the basis of surface meteorology measurements and global circulation models, raising the question of whether the abundant dunes and evidence for wind erosion seen on the planet are a current process. Recent studies showed sand activity, but could not determine whether entire dunes were moving—implying large sand fluxes—or whether more localized and surficial changes had occurred. Here we present measurements of the migration rate of sand ripples and dune lee fronts at the Nili Patera dune field. We show that the dunes are near steady state, with their entire volumes composed of mobile sand. The dunes have unexpectedly high sand fluxes, similar, for example, to those in Victoria Valley, Antarctica, implying that rates of landscape modification on Mars and Earth are similar

\u3ci\u3eLeucanthiza Dircella\u3c/i\u3e (Lepidoptera: Gracillariidae): A Leafminer of Leatherwood, \u3ci\u3eDirca Palustris\u3c/i\u3e

Leatherwood, Dirca palustris (Thymelaeaceae), is an understory shrub ranging throughout most of the eastern and central United States and adjacent Canada. During 1997-1999, we conducted studies to identify and assess the impact of a leafminer that was causing significant damage to leather- wood plants in eastern Gogebic County, Michigan. Leucanthiza dircella was identified as the only insect responsible for the leaf mining activity on leatherwood. In northern Michigan, L. dircella completed one generation per year. Adult moths were captured on yellow sticky panels suspended from leatherwood branches. In 1997 and 1998, most adults were captured during the first sampling period of each year: 6-12 June 1997 and 3-19 May 199B. In 1999, no moths were collected during 5-29 April but adults were collected between 30 April and 22 June 1999. In 1999, initiation of adult flight coincided with D. palustris leaf flush. In 1997, leaf mines were very noticeable by 30 June. The mean number of live L. dircella larvae per mine was 3.5 on 17 July 1997 and then decreased as the season progressed, with most larvae having exited the mines by late August to pupate in the soil. In late August 1997, the mean surface area of a single leaf was 17.8 cm2 and the mean surface area of a single mine was 5.9 cm2. At the end of the 1997 growing sea­son, 31% of the leatherwood leaves contained L. dircella mines, and 11% of the total leaf surface area had been mined. In 1999, only 8% of the leaves in the study area contained L. dircella mines. No leatherwood mortality was evident as a result of L. dircella leaf mining. Seven species of hymenopteran parasitoids were reared from L. dircella larvae, including one braconid in the genus Pholetesor and six eulophids in the genera Chrysocharis, Closterocerus, Pnigalio, and Sympiesis. Three coleopterans that were commonly observed on leatherwood plants during all years included: Glyptina brunnea (Chrysomelidae), Phyllobius oblongus (Curculionidae) and Polydrusus sericeus (Curculionidae)

Significance of low energy impact damage on modal parameters of composite beams by design of experiments

This paper presents an experimental study on the effects of multi-site damage on the vibration response of composite beams damaged by low energy impacts around the barely visible impact damage limit (BVID). The variation of the modal parameters with different levels of impact energy and density of damage is studied. Vibration tests have been carried out with both burst random and classical sine dwell excitations in order to compare that which of the methods among Polymax and Half Bandwidth Method is more suitable for damping estimation in the presence of damage. Design of experiments (DOE) performed on the experimental data show that natural frequency is a more sensitive parameter for damage detection than the damping ratio. It also highlighted energy of impact as the factor having a more significant effect on the modal parameters. Half Bandwidth Method is found to be unsuitable for damping estimation in the presence of damage

Possible X-ray diagnostic for jet/disk dominance in Type 1 AGN

Using Rossi X-ray Timing Explorer Seyfert 1 and 1.2 data spanning 9 years, we study correlations between X-ray spectral features. The sample consists of 350 time-resolved spectra from 12 Seyfert 1 and 1.2 galaxies. Each spectrum is fitted to a model with an intrinsic powerlaw X-ray spectrum produced close to the central black hole that is reprocessed and absorbed by material around the black hole. To test the robustness of our results, we performed Monte Carlo simulations of the spectral sample. We find a complex relationship between the iron line equivalent width (EW) and the underlying power law index (Gamma). The data reveal a correlation between Gamma and EW which turns over at Gamma <~ 2, but finds a weak anti-correlation for steeper photon indices. We propose that this relationship is driven by dilution of a disk spectrum (which includes the narrow iron line) by a beamed jet component and, hence, could be used as a diagnostic of jet-dominance. In addition, our sample shows a strong correlation between the reflection fraction (R) and Gamma, but we find that it is likely the result of modeling degeneracies. We also see the X-ray Baldwin effect (an anti-correlation between the 2-10 keV X-ray luminosity and EW) for the sample as a whole, but not for the individual galaxies and galaxy types.Comment: Accepted for publication in ApJ, 14 page

Radiative corrections to all charge assignments of heavy quark baryon semileptonic decays

In semileptonic decays of spin-1/2 baryons containing heavy quarks up to six charge assignments for the baryons and lepton are possible. We show that the radiative corrections to four of these possibilities can be directly obtained from the final results of the two possibilities previously studied. There is no need to recalculate integrals over virtual or real photon momentum or any traces.Comment: 15 pages, 2 figures, RevTex. Extended discussion. Final version to appear in Physical Review

Magnetic Properties of Epitaxial and Polycrystalline Fe/Si Multilayers

Fe/Si multilayers with antiferromagnetic interlayer coupling have been grown via ion-beam sputtering on both glass and single-crystal substrates. High-angle x-ray diffraction measurements show that both sets of films have narrow Fe peaks, implying a large crystallite size and crystalline iron silicide spacer layers. Low-angle x-ray diffraction measurements show that films grown on glass have rougher interfaces than those grown on single-crystal substrates. The multilayers grown on glass have a larger remanent magnetization than the multilayers grown on single-crystal substrates. The observation of magnetocrystalline anisotropy in hysteresis loops and $(hkl)$ peaks in x-ray diffraction demonstrates that the films grown on MgO and Ge are epitaxial. The smaller remanent magnetization in Fe/Si multilayers with better layering suggests that the remanence is not an intrinsic property.Comment: 9 pages, RevTex, 4 figures available by fax. Send email to [email protected] for more info. Submitted to '95 MMM proceeding