Parallel J-W Monte Carlo Simulations of Thermal Phase Changes in Finite-size Systems

The thermodynamic properties of 59 TeF6 clusters that undergo temperature-driven phase transitions have been calculated with a canonical J-walking Monte Carlo technique. A parallel code for simulations has been developed and optimized on SUN3500 and CRAY-T3E computers. The Lindemann criterion shows that the clusters transform from liquid to solid and then from one solid structure to another in the temperature region 60-130 K.Comment: 4 pages, 5 figures; presented at the conference on computational physics, Aachen (2001) accepted for publication in Comp.Phys.Com

Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer. Efficacy in combination with hormonal therapy

Background: Data on efficacy of bevacizumab (B) beyond first-line taxane -including regimen (BT) as first-line treatment are lacking. Although preclinical results that anti-angiogenic agents combined with hormonal therapy (HT) could be active, no clinical data exist about combination of maintenance Bevacizumab (mBev) with HT.Methods: Thirty-five patients who experienced a response after first-line BT, were given mBev at the dose of 15 mg/kg every 3 weeks. Among 30 pts with hormonal receptor-positive metastatic breast cancer (MBC), 20 (66.6%) received HT with mBev (mHTBev). Objective of the study was the outcome and safety of mBev and in two groups of patients receiving HT or not.Results: Complete response and partial response was achieved/maintained in 4 (11.4%) and 13 (37.1%) patients, respectively (overall response rate: 48.5%). Clinical benefit was obtained on 23 patients (65.7%). Median of mBev PFS and clinical benefit were 6.8 months (95% CI: 0.8-12.7) and 17.1 months (95% CI :12.2-21.9), respectively. Median PFS of patients who received mHTBev was longer than mBev without HT (13 months and 4.1 months, respectively, p = 0.05). The most common severe toxicities were proteinuria (11.4%) and hypertension (8.5%). No additional toxicity was observed with HTBev.Conclusion: Maintenance bevacizumab with or without anti-hormonal therapy in patients with hormone receptor positive breast cancer is tolerable and associated with long-term clinical outcome; these results encourage the strategy of prolonging bevacizumab until progression in combination with anti-hormonal agents

Inflammatory markers as prognostic factors of survival in patients affected by hepatocellular carcinoma undergoing transarterial chemoembolization

Transarterial chemoembolization (TACE) is a good choice for hepatocellular carcinoma (HCC) treatment when surgery and liver transplantation are not feasible. Few studies reported the value of prognostic factors influencing survival after chemoembolization. In this study, we evaluated whether preoperative inflammatory factors such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio affected our patient survival when affected by hepatocellular carcinoma. Methods. We retrospectively evaluated a total of 72 patients with hepatocellular carcinoma that underwent TACE. We enrolled patients with different etiopathogeneses of hepatitis and histologically proven HCC not suitable for surgery. The overall study population was dichotomized in two groups according to the median NLR value and was analyzed also according to other prognostic factors. Results. The global median overall survival (OS) was 28 months. The OS in patients with high NLR was statistically significantly shorter than that in patients with low NLR. The following pretreatment variables were significantly associated with the OS in univariate analyses: age, Child-Pugh score, BCLC stage, INR, and NLR. Pretreated high NLR was an independently unfavorable factor for OS. Conclusion. NLR could be considered a good prognostic factor of survival useful to stratify patients that could benefit from TACE treatment

Do institutional arrangements make a difference to transport policy and implementation? Lessons for Britain

This paper describes local government decision-making in transport in three areas of the UK, London, West Yorkshire and Edinburgh, in which major changes in local government decision-making structures have taken place over the last decade, and between which arrangements are now very different. The research discusses whether institutional change has had a beneficial or adverse effect, and whether any of the current structures provides a more effective framework for policy development and implementation. The results show that although the sites share a broadly common set of objectives there are differences in devolved responsibilities and in the extent to which various policy options are within the control of the bodies charged with transport policy delivery. The existence of several tiers of government, coupled with the many interactions required between these public sector bodies and the predominantly private sector public transport operators appears to create extra transactional barriers and impedes the implementation of the most effective measures for cutting congestion. There is, however, a compelling argument for the presence of an overarching tier of government to organise travel over a spatial scale compatible with that of major commuter patterns. The extent to which such arrangements currently appear to work is a function of the range of powers and the funding levels afforded to the co-ordinating organisation

How should we ‘care’ for LGBT+ students within higher education?

This article draws on a recent U.K. research project about lesbian, gay, bisexual and trans (LGBT+) perspectives on university to examine the implications for pastoral care and other service provision on campus. In a departure from previous scholarship that has tended to understand LGBT+ students as ‘vulnerable’ and/or needing ‘support’, it argues that university spaces should be (re)framed in a way that moves beyond (only) personal or individual ‘care’. The article outlines some of the issues that LGBT+ students may face under the following headings: Curriculum and course content; Discrimination, prejudice and bullying; Facilities and service provision on campus; A continuum of experiences. Following these, a final section draws some conclusions and implications for practice in higher education

The expanding scenario of advanced non-small-cell lung cancer between emerging evidence and clinical tasks

: This Editorial by De Giglio, Ricciuti and Metro introduces the series Treatment of advanced non-small-cell lung cancer: one size does not fit all: https://www.drugsincontext.com/special_issues/treatment-of-advanced-non-small-cell-lung-cancer-one-size-does-not-fit-all/

Targeting angiogenesis in advanced non-small-cell lung cancer: are biomarkers needed?

n/

ANALISIS SISTEM PERAWATAN PADA HIDROLIK MESIN PEMOTONG PADI

Pada dasarnya Sistem hidrolik sebetulnya sudah banyak dikenal oleh kalangan masyarakat luas. Salah satu yang berperan penting dalam sistem hidrolik adalah silinder hidrolik, dari beberapa data yang ada, kerusakan yang paling sering ditemukan dalam sistem hidrolik yaitu silinder hidrolik. Silinder hidrolik berperan penting dalam mempermudah dan mempercepat sistem kerja pemanen atau pemotong padi. Silinder hidrolik berguna untuk menaikkan Bucket (penuai), Reel (penggulung). Silinder hidrolik memiliki presentase kerusakan yang cukup besar. Berdasarkan latar belakang permasalahan diatas, maka rumusan masalah yang dibahas adalah bagaimana mengetahui nilai Availability, Performance, dan Rate Of Quality dengan metode Overal Equipment Effectivenes (OEE) serta meminimalisir kerusakan silinder hidrolik menggunakan metode TPM (Total Productive Maintenance), mengetahui penyebab kerusakan pada silinder hidrolik. Mengetahui usulan masalah pada silinder hidrolik, Mengetahui faktor penyebab dan kerusakan pada silinder hidrolik, Pemeliharaan (maintenance) merupakan suatu kegiatan untuk memelihara atau menjaga fasilitas atau suatu mesin dan mengadakan perbaikan atau pergantian yang diperlukan agar dapat menghasilkan tenaga yang maksimum dan umur mesin yang awet. Dari hasil perhitungan nilai avaibility tersebut maka rasio operation time unit terhadap loading time periode maret – juni sesuai dengan standart dunia 90%. Untuk perhitungan nilai persentase performa efficiency belum sesuai standar dunia 95% dan untuk perhitungan nilai rate of quality belum sesuai dengan standart dunia 99,9%, kemudian dari perhitungan nilai persentase Overal Equipment Effectiveness Dari perhitungan nilai persentase Overal Equipment Effectiveness belum sesuai dengan standart dunia 85%

COX-2 targeting in cancer: a new beginning?

Cyclo-oxygenase-2 (COX-2), the inducible enzyme catalyzing the rate-limiting step in the conversion of arachidonic acid into eicosanoids, is overexpressed in a wide variety of malignancies and associates with poor prognostic features [1]. Consequently, selective COX-2 inhibitors have been explored as therapeutic or chemopreventive agents in different settings; however, initial enthusiasm was tempered by reports of substantial gastrointestinal toxicity as well as of increased cardiovascular risk, mostly coming from postmarketing use as anti-inflammatory drugs and Cancer Research Campaign (UK) chemoprevention trials and eventually resulting in the withdrawal of rofecoxib from the market [2]