Ironing out the details: Untangling dietary iron and genetic background in diabetes

The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health. Genetic variation between individuals confers differences in metabolism, which directly impacts response to diet. Most studies attempting to identify genetic risk factors in disease fail to incorporate dietary components, and thus are ill-equipped to capture the breadth of the genome’s impact on metabolism. Understanding how genetic background interacts with nutrients holds the key to predicting and preventing metabolic diseases through the implementation of personalized nutrition. Dysregulation of iron homeostasis is associated with type-II diabetes, but the link between dietary iron and metabolic dysfunction is poorly defined. High iron burden in adipose tissue induces insulin resistance, but the mechanisms underlying adipose iron accumulation remain unknown. Hepcidin controls dietary iron absorption and distribution in metabolic tissues, but it is unknown whether genetic variation influencing hepcidin expression modifies susceptibility to dietary iron-induced insulin resistance. This review highlights discoveries concerning the axis of iron homeostasis and adipose function and suggests that genetic variation underlying dietary iron metabolism is an understudied component of metabolic disease

ING4 (inhibitor of growth family, member 4)

Review on ING4 (inhibitor of growth family, member 4), with data on DNA, on the protein encoded, and where the gene is implicated

Performance of a New Enhanced Topological Decision-Rule Map-Matching Algorithm for Transportation Applications

Indexación: Web of Science; ScieloMap-matching problems arise in numerous transportation-related applications when spatial data is collected using inaccurate GPS technology and integrated with a flawed digital roadway map in a GIS environment. This paper presents a new enhanced post-processing topological decision-rule map-matching algorithm in order to address relevant special cases that occur in the spatial mismatch resolution. The proposed map-matching algorithm includes simple algorithmic improvements: dynamic buffer that varies its size to snap GPS data points to at least one roadway centerline; a comparison between vehicle heading measurements and associated roadway centerline direction; and a new design of the sequence of steps in the algorithm architecture. The original and new versions of the algorithm were tested on different spatial data qualities collected in Canada and United States. Although both versions satisfactorily resolve complex spatial ambiguities, the comparative and statistical analysis indicates that the new algorithm with the simple algorithmic improvements outperformed the original version of the map-matching algorithm.El problema de la ambigüedad espacial ocurre en varias aplicaciones relacionadas con transporte, específicamente cuando existe inexactitud en los datos espaciales capturados con tecnología GPS o cuando son integrados con un mapa digital que posee errores en un ambiente SIG. Este artículo presenta un algoritmo nuevo y mejorado basado en reglas de decisión que es capaz de resolver casos especiales relevantes en modo post-proceso. El algoritmo propuesto incluye las siguientes mejoras algorítmicas: un área de búsqueda dinámica que varía su tamaño para asociar puntos GPS a al menos un eje de calzada, una comparación entre el rumbo del vehículo y la dirección del eje de calzada asignada, y un nuevo diseño de la secuencia de pasos del algoritmo. Tanto el algoritmo original como el propuesto fueron examinados con datos espaciales de diferentes calidades capturados en Canadá y Estados Unidos. Aunque ambas versiones resuelven satisfactoriamente el problema de ambigüedad espacial, el análisis comparativo y estadístico indica que la nueva versión del algoritmo con las mejoras algorítmicas entrega resultados superiores a la versión original del algoritmo.http://ref.scielo.org/9mt55

Spacecraft particulate sizing spectrometer

An evaluation prototype device is described, together with conclusions and several recommendations for follow-on flight hardware. The device detects individual particles crossing an external sensing zone, and produces a histogram displaying the size distribution of particles sensed, over the nominal range of 5 to 50 microns. The output is totally independent of the particle refractive index, and is also largely unaffected by particle shape. The reported diameters are in terms of the equivalent sphere, as judged by the scattered light intercepted by the receiving channels, which develop signals whenever a particle crosses the beam of illumination in the sensing zone. Supporting evidence for the latter assertion is discussed on the basis of experimental test data for non-spherical particulates. Also included is a technical appendix which presents theoretical arguments that provide a firm foundation for this assertion