Reliable Semiclassical Computations in QCD

We revisit the question of whether or not one can perform reliable semiclassical QCD computations at zero temperature. We study correlation functions with no perturbative contributions, and organize the problem by means of the operator product expansion, establishing a precise criterion for the validity of a semiclassical calculation. For $N_f>N$, a systematic computation is possible; for $N_f<N$, it is not. $N_f=N$ is a borderline case. In our analysis, we see explicitly the exponential suppression of instanton effects at large $N$. As an application, we describe a test of QCD lattice gauge theory computations in the chiral limit.Comment: 16 page

Kinematic Orbits and the Structure of the Internal Space for Systems of Five or More Bodies

The internal space for a molecule, atom, or other n-body system can be conveniently parameterised by 3n-9 kinematic angles and three kinematic invariants. For a fixed set of kinematic invariants, the kinematic angles parameterise a subspace, called a kinematic orbit, of the n-body internal space. Building on an earlier analysis of the three- and four-body problems, we derive the form of these kinematic orbits (that is, their topology) for the general n-body problem. The case n=5 is studied in detail, along with the previously studied cases n=3,4.Comment: 38 pages, submitted to J. Phys.

GEM Operation in Negative Ion Drift Gas Mixtures

The first operation of GEM gas gain elements in negative ion gas mixtures is reported. Gains up to several thousand were obtained from single-stage GEMs in carbon disulfide vapor at low pressure, and in mixtures of carbon disulfide with Argon and Helium, some near 1 bar total pressure.Comment: 7 pages, 3 figure

Characteristics of a New Carbonaceous Chondrite, Metal-Rich-Lithology Found in the Carbonaceous Chondrite Breccia Aguas Zarcas

The Aguas Zarcas meteorite fell in Costa Rica on 23 April 2019 at 21:07 local time, with a total mass of about 27 kg. Hundreds of fusion-crusted stones ranging from 0.1 to 1868 g were recovered (The Meteoritical Bulletin). The meteorite was classified as a CM chondrite, but some lithlogies show a different texture to that of CM. In this study, we investigated the petrography, mineral-ogy, chemistry, and isotopic composition of an unusual Metal-rich-lithology from this fresh fall

Adam Smith and Colonialism

In the context of debates about liberalism and colonialism, the arguments of Adam Smith have been taken as illustrative of an important line of anti-colonial liberal thought. The reading of Smith presented here challenges this interpretation. It argues that Smith’s opposition to colonial rule derived largely from its impact on the metropole, rather than on its impact on the conquered and colonised; that Smith recognised colonialism had brought ‘improvement’ in conquered territories and that Smith struggled to balance recognition of moral diversity with a universal moral framework and a commitment to a particular interpretation of progress through history. These arguments have a wider significance as they point towards some of the issues at stake in liberal anti-colonial arguments more generally

Aging is associated with an earlier arrival of reflected waves without a distal shift in reflection sites

Background-Despite pronounced increases in central pulse wave velocity (PWV) with aging, reflected wave transit time (RWTT), traditionally defined as the timing of the inflection point (T-INF) in the central pressure waveform, does not appreciably decrease, leading to the controversial proposition of a "distal-shift" of reflection sites. T-INF, however, is exceptionally prone to measurement error and is also affected by ejection pattern and not only by wave reflection. We assessed whether RWTT, assessed by advanced pressure-flow analysis, demonstrates the expected decline with aging. Methods and Results-We studied a sample of unselected adults without cardiovascular disease (n=48; median age 48 years) and a clinical population of older adults with suspected/established cardiovascular disease (n=164; 61 years). We measured central pressure and flow with carotid tonometry and phase-contrast MRI, respectively. We assessed RWTT using wave-separation analysis (RWTTWSA) and partially distributed tube-load (TL) modeling (RWTTTL). Consistent with previous reports, T-INF did not appreciably decrease with age despite pronounced increases in PWV in both populations. However, aging was associated with pronounced decreases in RWTTWSA (general population -15.0 ms/decade, P<0.001; clinical population -9.07 ms/decade, P=0.003) and RWTTTL (general -15.8 ms/decade, P<0.001; clinical -11.8 ms/decade, P<0.001). There was no evidence of an increased effective reflecting distance by either method. TINF was shown to reliably represent RWTT only under highly unrealistic assumptions about input impedance. Conclusions-RWTT declines with age in parallel with increased PWV, with earlier effects of wave reflections and without a distal shift in reflecting sites. These findings have important implications for our understanding of the role of wave reflections with aging

Phase I trial of procarbazine as a 5-day continuous infusion in children with central nervous system tumors.

Seven children with previously treated brain tumors were enrolled in a phase I trial of 5-day continuous-infusion procarbazine at 360, 480, and 638 mg/m2/day. Vitamin B6 levels were monitored. Myelosuppression was moderate though occasionally delayed, and nausea and vomiting were mild. At the highest dose level, a patient experienced severe psychosis that persisted for several weeks. From that dose-limiting toxicity and the degree of myelosuppression, the recommended dose for phase II trials in children is the same as for adults, 450 mg/m2/day

Information theoretic approach to interactive learning

The principles of statistical mechanics and information theory play an important role in learning and have inspired both theory and the design of numerous machine learning algorithms. The new aspect in this paper is a focus on integrating feedback from the learner. A quantitative approach to interactive learning and adaptive behavior is proposed, integrating model- and decision-making into one theoretical framework. This paper follows simple principles by requiring that the observer's world model and action policy should result in maximal predictive power at minimal complexity. Classes of optimal action policies and of optimal models are derived from an objective function that reflects this trade-off between prediction and complexity. The resulting optimal models then summarize, at different levels of abstraction, the process's causal organization in the presence of the learner's actions. A fundamental consequence of the proposed principle is that the learner's optimal action policies balance exploration and control as an emerging property. Interestingly, the explorative component is present in the absence of policy randomness, i.e. in the optimal deterministic behavior. This is a direct result of requiring maximal predictive power in the presence of feedback.Comment: 6 page