8 research outputs found
Glucose and fatty acid metabolism in infarcted heart from streptozotocin-induced diabetic rats after 2 weeks of tissue remodeling
Full text linkFunctional and Electrophysiological Consequences of Chronic Treatment With Spironolactone in Comparison With Lisinopril During Low-Flow Ischemia and Reperfusion in Isolated Rat Hearts
Full text linkElectrophysiological approach of the role of Na<sup>+</sup>/H<sup>+</sup> exchange in low-flow global ischemia and in ischemic preconditioning
Full text linkElectrophysiological approach of the role of Na<SUP>+</SUP>/H<SUP>+</SUP> exchange in low-flow global ischemia and in ischemic preconditioning
No full textFunctional and electrophysiological consequences of chronic treatment with spironolactone in comparison with lisinopril during low-flow ischemia and reperfusion in isolated rat hearts
Get PDFDimethyl disulfide exerts insecticidal neurotoxicity through mitochondrial dysfunction and activation of insect K_ATP channels
No full textInternational audienc
Genomic and nongenomic effects of aldosterone in the rat heart: why is spironolactone cardioprotective?
No full text1. Mineralocorticoid receptor (MR) antagonism with spironolactone reduces mortality in heart failure on top of ACE inhibition. To investigate the underlying mechanism, we compared the actions of both aldosterone and spironolactone to those of angiotensin (Ang) II in the rat heart. 2. Hearts of male Wistar rats were perfused according to Langendorff. Ang II and aldosterone increased left ventricular pressure (LVP) by maximally 11+/-4 and 9+/-2%, and decreased coronary flow (CF) by maximally 36+/-7 and 20+/-4%, respectively. Sp
