A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing

Acid-sensitive K+ channels of the tandem P-domain K+-channel family (TASK-1 and TASK-3) have been implicated in peripheral and central respiratory chemosensitivity; however, because of the lack of decisive pharmacological agents, the final proof of the role of the TASK channel in the chemosensory control of breathing has been missing. In the mouse, TASK-1 and TASK-3 channels are dispensable for central respiratory chemosensitivity (Mulkey et al., 2007Go). Here, we have used knock-out animals to determine whether TASK-1 and TASK-3 channels play a role in the carotid body function and chemosensory control of breathing exerted by the carotid body chemoreceptors. Ventilatory responses to hypoxia (10% O2 in inspired air) and moderate normoxic hypercapnia (3–6% CO2 in inspired air) were significantly reduced in TASK-1 knock-out mice. In contrast, TASK-3-deficient mice showed responses to both stimuli that were similar to those developed by their wild-type counterparts. TASK-1 channel deficiency resulted in a marked reduction of the hypoxia (by 49%)- and CO2 (by 68%)-evoked increases in the carotid sinus nerve chemoafferent discharge recorded in the in vitro superfused carotid body/carotid sinus nerve preparations. Deficiency in both TASK-1 and TASK-3 channels increased baseline chemoafferent activity but did not cause a further reduction of the carotid body chemosensory responses. These observations provide direct evidence that TASK-1 channels contribute significantly to the increases in the carotid body chemoafferent discharge in response to a decrease in arterial PO2 or an increase in PCO2/[H+]. TASK-1 channels therefore play a key role in the control of ventilation by peripheral chemoreceptors

ESTIMATED IMPACT OF NON-PRICE COORDINATION OF FED CATTLE PURCHASES ON MEAT PACKER PROCESSING COSTS

Stochastic simulation of daily slaughter level was used in conjunction with an estimated packing plant cost curve to assess potential reductions in processing costs due to improved vertical coordination between feedlots and packing plants. Results indicate that processing cost reductions of $1 to$5 per head may be possible. Savings result from ensuring a more stable processing volume that is near the plant's cost-minimizing level of production.cattle, cost curve, meat packing, vertical coordination, Industrial Organization, Livestock Production/Industries,

Linearly independent pure-state decomposition and quantum state discrimination

We put the pure-state decomposition mathematical property of a mixed state to a physical test. We begin by characterizing all the possible decompositions of a rank-two mixed state by means of the complex overlap between two involved states. The physical test proposes a scheme of quantum state recognition of one of the two linearly independent states which arise from the decomposition. We find that the two states associated with the balanced pure-state decomposition have the smaller overlap modulus and therefore the smallest probability of being discriminated conclusively, while in the nonconclusive scheme they have the highest probability of having an error. In addition, we design an experimental scheme which allows to discriminate conclusively and optimally two nonorthogonal states prepared with different a priori probabilities. Thus, we propose a physical implementation for this linearly independent pure-state decomposition and state discrimination test by using twin photons generated in the process of spontaneous parametric down conversion. The information-state is encoded in one photon polarization state whereas the second single-photon is used for heralded detection.Comment: 6 pages, 5 figures, Submitted to Phys. Rev.

Quantitative evaluation of polymer gel dosimeters by broadband ultrasound attenuation

Ultrasound has been examined previously as an alternative readout method for irradiated polymer gel dosimeters, with authors reporting varying dose response to ultrasound transmission measurements. In this current work we extend previous work to measure the broadband ultrasound attenuation (BUA) response of irradiated PAGAT gel dosimeters, using a novel ultrasound computed tomography system